WFRF:(Krohn K.)
Sökning: WFRF:(Krohn K.) > (2015-2019) > PPD ACT: an app-bas...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02638naa a2200397 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:139736046 | |
| 003 | SwePub | |
| 008 | 240701s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1397360462 URI |
| 024 | 7 | a https://doi.org/10.1038/s41398-018-0305-52 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Guintivano, J4 aut |
| 245 | 1 0 | a PPD ACT: an app-based genetic study of postpartum depression |
| 264 | c 2018-11-29 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2018 |
| 520 | a Postpartum depression (PPD) is one of the most frequent complications of childbirth and particularly is suited to genetic investigation as it is more homogenous than major depression outside of the perinatal period. We developed an iOS app (PPD ACT) to recruit, consent, screen, and enable DNA collection from women with a lifetime history of PPD to sufficiently power genome-wide association studies. In 1 year, we recruited 7344 women with a history of PPD and have biobanked 2946 DNA samples from the US. This sample of PPD cases was notably severely affected and within 2 years of their worst episode of PPD. Clinical validation was performed within a hospital setting on a subset of participants and recall validity assessed 6–9 months after initial assessment to ensure reliability of screening tools. Here we detail the creation of the PPD ACT mobile app including design, ethical, security, and deployment considerations. We emphasize the importance of multidisciplinary collaboration to correctly implement such a research project. Additionally, we describe our ability to customize the PPD ACT platform to deploy internationally in order to collect a global sample of women with PPD. | |
| 700 | 1 | a Krohn, H4 aut |
| 700 | 1 | a Lewis, C4 aut |
| 700 | 1 | a Byrne, EM4 aut |
| 700 | 1 | a Henders, AK4 aut |
| 700 | 1 | a Ploner, Au Karolinska Institutet4 aut |
| 700 | 1 | a Kirk, K4 aut |
| 700 | 1 | a Martin, NG4 aut |
| 700 | 1 | a Milgrom, J4 aut |
| 700 | 1 | a Wray, NR4 aut |
| 700 | 1 | a Sullivan, PFu Karolinska Institutet4 aut |
| 700 | 1 | a Meltzer-Brody, S4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Translational psychiatryd : Springer Science and Business Media LLCg 8:1, s. 260-q 8:1<260-x 2158-3188 |
| 856 | 4 | u https://www.nature.com/articles/s41398-018-0305-5.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:139736046 |
| 856 | 4 8 | u https://doi.org/10.1038/s41398-018-0305-5 |
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