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Sökning: WFRF:(Nyberg M) > (2010-2014) > ANP and BNP Respons...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003462naa a2200409 4500
001oai:DiVA.org:uu-200116
003SwePub
008130520s2013 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2001162 URI
0247 a https://doi.org/10.1371/journal.pone.00578062 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Adem, Abdu4 aut
2451 0a ANP and BNP Responses to Dehydration in the One-Humped Camel and Effects of Blocking the Renin-Angiotensin System
264 c 2013-03-13
264 1b Public Library of Science (PLoS),c 2013
338 a electronic2 rdacarrier
520 a The objectives of this study were to investigate and compare the responses of atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) in the circulation of hydrated, dehydrated, and dehydrated losartan - treated camels; and to document the cardiac storage form of B-type natriuretic peptide in the camel heart. Eighteen male camels were used in the study: control or hydrated camels (n = 6), dehydrated camels (n = 6) and dehydrated losartan-treated camels (n = 6) which were dehydrated and received the angiotensin II (Ang II) AT-1 receptor blocker, losartan, at a dose of 5 mg/kg body weight intravenously for 20 days. Control animals were supplied with feed and water ad-libitum while both dehydrated and dehydrated-losartan treated groups were supplied with feed ad-libitum but no water for 20 days. Compared with time-matched controls, dehydrated camels exhibited a significant decrease in plasma levels of both ANP and BNP. Losartan-treated camels also exhibited a significant decline in ANP and BNP levels across 20 days of dehydration but the changes were not different from those seen with dehydration alone. Size exclusion high performance liquid chromatography of extracts of camel heart indicated that proB-type natriuretic peptide is the storage form of the peptide. We conclude first, that dehydration in the camel induces vigorous decrements in circulating levels of ANP and BNP; second, blockade of the renin-angiotensin system has little or no modulatory effect on the ANP and BNP responses to dehydration; third, proB-type natriuretic peptide is the storage form of this hormone in the heart of the one-humped camel.
7001 a Al Haj, Mahmoudu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut
7001 a Benedict, Sheela4 aut
7001 a Yasin, Javed4 aut
7001 a Nagelkerke, Nicolas4 aut
7001 a Nyberg, Fredu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)frednybe
7001 a Yandle, Tim G.4 aut
7001 a Frampton, Chris M.4 aut
7001 a Lewis, Lynley K.4 aut
7001 a Nicholls, M. Gary4 aut
7001 a Kazzam, Elsadig4 aut
7102 a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org
7730 t PLOS ONEd : Public Library of Science (PLoS)g 8:3, s. e57806-q 8:3<e57806-x 1932-6203
8564 u https://uu.diva-portal.org/smash/get/diva2:622418/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0057806&type=printable
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-200116
8564 8u https://doi.org/10.1371/journal.pone.0057806

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