Sökning: onr:"swepub:oai:gup.ub.gu.se/325095" > Protein disulfide i...
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000 | 04600naa a2200685 4500 | |
001 | oai:gup.ub.gu.se/325095 | |
003 | SwePub | |
008 | 240528s2023 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:152039241 | |
024 | 7 | a https://gup.ub.gu.se/publication/3250952 URI |
024 | 7 | a https://doi.org/10.1002/alz.129782 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1520392412 URI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Wolzak, K.4 aut |
245 | 1 0 | a Protein disulfide isomerases as CSF biomarkers for the neuronal response to tau pathology |
264 | c 2023-02-24 | |
264 | 1 | b Wiley,c 2023 |
520 | a IntroductionCerebrospinal fluid (CSF) biomarkers for specific cellular disease processes are lacking for tauopathies. In this translational study we aimed to identify CSF biomarkers reflecting early tau pathology-associated unfolded protein response (UPR) activation. MethodsWe employed mass spectrometry proteomics and targeted immunoanalysis in a combination of biomarker discovery in primary mouse neurons in vitro and validation in patient CSF from two independent large multicentre cohorts (EMIF-AD MBD, n = 310; PRIDE, n = 771). ResultsFirst, we identify members of the protein disulfide isomerase (PDI) family in the neuronal UPR-activated secretome and validate secretion upon tau aggregation in vitro. Next, we demonstrate that PDIA1 and PDIA3 levels correlate with total- and phosphorylated-tau levels in CSF. PDIA1 levels are increased in CSF from AD patients compared to controls and patients with tau-unrelated frontotemporal and Lewy body dementia (LBD). HighlightsNeuronal unfolded protein response (UPR) activation induces the secretion of protein disulfide isomerases (PDIs) in vitro.PDIA1 is secreted upon tau aggregation in neurons in vitro.PDIA1 and PDIA3 levels correlate with total and phosphorylated tau levels in CSF.PDIA1 levels are increased in CSF from Alzheimer's disease (AD) patients compared to controls.PDIA1 levels are not increased in CSF from tau-unrelated frontotemporal dementia (FTD) and Lewy body dementia (LBD) patients. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
653 | a Alzheimer's disease | |
653 | a CSF biomarker | |
653 | a PDI | |
653 | a tau pathology | |
653 | a UPR | |
653 | a alzheimers-disease | |
653 | a cerebrospinal-fluid | |
653 | a aggregation | |
653 | a pathway | |
653 | a neurodegeneration | |
653 | a secretion | |
653 | a insights | |
653 | a Neurosciences & Neurology | |
700 | 1 | a Vermunt, L.4 aut |
700 | 1 | a del Campo, M.4 aut |
700 | 1 | a Jorge-Oliva, M.4 aut |
700 | 1 | a van Ziel, A. M.4 aut |
700 | 1 | a Li, K. W.4 aut |
700 | 1 | a Smit, A. B.4 aut |
700 | 1 | a Chen-Ploktkin, A.4 aut |
700 | 1 | a Irwin, D. J.4 aut |
700 | 1 | a Lemstra, A. W.4 aut |
700 | 1 | a Pijnenburg, Y.4 aut |
700 | 1 | a van der Flier, W.4 aut |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Gobom, Johanu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xgobjo |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Visser, P. J.4 aut |
700 | 1 | a Teunissen, C. E.4 aut |
700 | 1 | a Tijms, B. M.4 aut |
700 | 1 | a Scheper, W.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Alzheimers & Dementiad : Wileyg 19:8, s. 3563-3574q 19:8<3563-3574x 1552-5260x 1552-5279 |
856 | 4 8 | u https://gup.ub.gu.se/publication/325095 |
856 | 4 8 | u https://doi.org/10.1002/alz.12978 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:152039241 |
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