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Sökning: WFRF:(Pham L) > (2020-2024) > Brain and blood bio...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05159naa a2200829 4500 | |
| 001 | oai:gup.ub.gu.se/291058 | |
| 003 | SwePub | |
| 008 | 240528s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2910582 URI |
| 024 | 7 | a https://doi.org/10.1038/s41380-020-0674-z2 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Dickstein, D. L.4 aut |
| 245 | 1 0 | a Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure |
| 264 | c 2020-02-25 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2021 |
| 520 | a Traumatic brain injury (TBI) is a risk factor for the later development of neurodegenerative diseases that may have various underlying pathologies. Chronic traumatic encephalopathy (CTE) in particular is associated with repetitive mild TBI (mTBI) and is characterized pathologically by aggregation of hyperphosphorylated tau into neurofibrillary tangles (NFTs). CTE may be suspected when behavior, cognition, and/or memory deteriorate following repetitive mTBI. Exposure to blast overpressure from improvised explosive devices (IEDs) has been implicated as a potential antecedent for CTE amongst Iraq and Afghanistan Warfighters. In this study, we identified biomarker signatures in rats exposed to repetitive low-level blast that develop chronic anxiety-related traits and in human veterans exposed to IED blasts in theater with behavioral, cognitive, and/or memory complaints. Rats exposed to repetitive low-level blasts accumulated abnormal hyperphosphorylated tau in neuronal perikarya and perivascular astroglial processes. Using positron emission tomography (PET) and the [F-18]AV1451 (flortaucipir) tau ligand, we found that five of 10 veterans exhibited excessive retention of [F-18]AV1451 at the white/gray matter junction in frontal, parietal, and temporal brain regions, a typical localization of CTE tauopathy. We also observed elevated levels of neurofilament light (NfL) chain protein in the plasma of veterans displaying excess [F-18]AV1451 retention. These findings suggest an association linking blast injury, tauopathy, and neuronal injury. Further study is required to determine whether clinical, neuroimaging, and/or fluid biomarker signatures can improve the diagnosis of long-term neuropsychiatric sequelae of mTBI. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a persistent postconcussive symptoms | |
| 653 | a military service members | |
| 653 | a pet tracer | |
| 653 | a f-18-av-1451 | |
| 653 | a disorder-related traits | |
| 653 | a cognitive impairment | |
| 653 | a tau | |
| 653 | a model | |
| 653 | a expression | |
| 653 | a dementia | |
| 653 | a disease | |
| 653 | a Biochemistry & Molecular Biology | |
| 653 | a Neurosciences & Neurology | |
| 653 | a Psychiatry | |
| 700 | 1 | a De Gasperi, R.4 aut |
| 700 | 1 | a Sosa, M. G. A.4 aut |
| 700 | 1 | a Perez-Garcia, G.4 aut |
| 700 | 1 | a Short, J. A.4 aut |
| 700 | 1 | a Sosa, H.4 aut |
| 700 | 1 | a Perez, G. M.4 aut |
| 700 | 1 | a Tschiffely, A. E.4 aut |
| 700 | 1 | a Dams-O'Connor, K.4 aut |
| 700 | 1 | a Pullman, M. Y.4 aut |
| 700 | 1 | a Knesaurek, K.4 aut |
| 700 | 1 | a Knutsen, A.4 aut |
| 700 | 1 | a Pham, D. L.4 aut |
| 700 | 1 | a Soleimani, L.4 aut |
| 700 | 1 | a Jordan, B. D.4 aut |
| 700 | 1 | a Gordon, W. A.4 aut |
| 700 | 1 | a Delman, B. N.4 aut |
| 700 | 1 | a Shumyatsky, G.4 aut |
| 700 | 1 | a Shahim, P. P.4 aut |
| 700 | 1 | a DeKosky, S. T.4 aut |
| 700 | 1 | a Stone, J. R.4 aut |
| 700 | 1 | a Peskind, E.4 aut |
| 700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
| 700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
| 700 | 1 | a Chance, S. A.4 aut |
| 700 | 1 | a Torso, M.4 aut |
| 700 | 1 | a Kostakoglu, L.4 aut |
| 700 | 1 | a Sano, M.4 aut |
| 700 | 1 | a Hof, P. R.4 aut |
| 700 | 1 | a Ahlers, S. T.4 aut |
| 700 | 1 | a Gandy, S.4 aut |
| 700 | 1 | a Elder, G. A.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t Molecular Psychiatryd : Springer Science and Business Media LLCg 26, s. 5940-5954q 26<5940-5954x 1359-4184x 1476-5578 |
| 856 | 4 | u https://www.nature.com/articles/s41380-020-0674-z.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/291058 |
| 856 | 4 8 | u https://doi.org/10.1038/s41380-020-0674-z |
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