Pathogenic immunity in systemic lupus erythematous and atherosclerosis: common mechanisms and possible targets for intervention.

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Fältnamn	Indikatorer	Metadata
000		03815naa a2200361 4500
001		oai:lup.lub.lu.se:8a8a09e5-4031-457a-8d80-7ef33b70a93a
003		SwePub
008		160401s2015 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/51426332 URI
024	7	a https://doi.org/10.1111/joim.123572 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a for2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Wigren, Mariau Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups4 aut0 (Swepub:lu)med-mbr
245	1 0	a Pathogenic immunity in systemic lupus erythematous and atherosclerosis: common mechanisms and possible targets for intervention.
264		c 2015-10-19
264	1	b Wiley,c 2015
338		a electronic2 rdacarrier
520		a Systemic lupus erythematous (SLE) is an autoimmune disorder that primarily affects young women and is characterized by inflammation in several organs including the kidneys, skin, joints, blood, and nervous system. Abnormal immune cellular and humoral responses play important roles in the development of the disease process. Impaired clearance of apoptotic material is a key factor contributing to activation of self-reactive immune cells. The incidence of atherosclerotic cardiovascular disease (CVD) is increased up to 50-fold in SLE patients compared to age- and gender-matched control subjects and this can only partly be explained by traditional risk factors for CVD. Currently, there is no effective treatment to prevent CVD complications in SLE. Traditional preventive CVD therapies have not been found to significantly lower the incidence of CVD in SLE; therefore, there is a need for novel treatment strategies and increased understanding of the mechanisms involved in the pathogenesis of CVD complications in SLE. The pathogenic immune responses in SLE and development of atherosclerotic plaques share some characteristics, such as impaired efferocytosis and skewed T cell activation, suggesting the possibility of identifying novel targets for intervention. As novel immune-based therapies for CVD are being developed, it is possible that some of these may be effective for the prevention of CVD and for immunomodulation in SLE. However, further understanding of the mechanisms leading to an increased prevalence of cardiovascular events in SLE is critical for the development of such therapies. This article is protected by copyright. All rights reserved.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
700	1	a Nilsson, Janu Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups4 aut0 (Swepub:lu)medf-jni
700	1	a Kaplan, Mariana J4 aut
710	2	a Kardiovaskulär forskning - immunitet och aterosklerosb Forskargrupper vid Lunds universitet4 org
773	0	t Journal of Internal Medicined : Wileyg 278:5, s. 494-506q 278:5<494-506x 1365-2796x 0954-6820
856	4	u https://portal.research.lu.se/files/2423507/8145750.pdfx primaryx freey FULLTEXT
856	4	u http://www.ncbi.nlm.nih.gov/pubmed/25720452?dopt=Abstracty FULLTEXT
856	4	u http://dx.doi.org/10.1111/joim.12357y FULLTEXT
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/joim.12357
856	4 8	u https://lup.lub.lu.se/record/5142633
856	4 8	u https://doi.org/10.1111/joim.12357

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Av författaren/redakt...: Wigren, Maria; Nilsson, Jan; Kaplan, Mariana ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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