hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Medicinska och farmaceutiska grundvetenskaper) hsv:(Neurovetenskaper)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04606nam a2200421 4500 | |
| 001 | oai:gup.ub.gu.se/308886 | |
| 003 | SwePub | |
| 008 | 240528s2021 | |||||||||||000 ||eng| | |
| 020 | a 9789180094436 | |
| 024 | 7 | a 2077/693222 hdl |
| 024 | 7 | a https://gup.ub.gu.se/publication/3088862 URI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a vet2 swepub-contenttype |
| 072 | 7 | a dok2 swepub-publicationtype |
| 100 | 1 | a Chebli, Jasmineu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut |
| 245 | 1 0 | a Physiological roles of amyloid precursor protein in vivo - zebrafish as a model |
| 264 | 1 | b Göteborgs universitet,c 2021 |
| 520 | a Amyloid-beta precursor protein (APP) is an evolutionarily conserved transmembrane protein expressed in many different tissues. APP belongs to a gene family consisting of two other APP-like proteins (APLP1 and APLP2). APP has been shown to be involved in biological processes such as neurite outgrowth, neuronal migration, synapse formation and plasticity, and cell-cell interactions. APP also plays a central role in the development of Alzheimer's disease (AD). APP's physiological role has been difficult to understand and despite all research is not yet completely understood. The purpose of this thesis was to study the role of APP during early development with zebrafish as the main model system. We have focused on the zebrafish's Apps and have tried to understand their function with the help of genetic knockout models created using the CRISPR / Cas9 method. We report that appb mutants have weakened cell adhesions that give rise to changes in cell organization. We also report that the appb mutants are smaller but develop into fertile and healthy adult individuals. We also found defects in the formation of the trigeminal ganglia (TG) and that Appb seems to have a role in cell-cell interaction. The more widespread TG also consisted of fewer nerve cells, indicating that Appb promotes nerve cell formation. Furthermore, our studies demonstrate APP expression in cilia on sensory nerve cells and ependymal cells covering the brain chambers. The conserved expression of APP in ependymal cilia in mice and humans suggest an important and preserved function. Zebrafish with mutated App were found to have defects in the formation of both cilia and cerebral ventricles. To identify new signalling pathways through which Appb controls these functions, we studied protein changes in appb mutants using mass spectrometry. These studies highlight changes that both confirm known and suggest new regulations by appb, especially in neural development, cell adhesion and in gene regulation. Finally, we tried to answer the underlying mechanisms behind compensation within the App family. We found that mutations in the app genes activate expression of homologous genes via so-called transcriptional adaptation. In conclusion, the findings reported in this thesis showed that App is implicated already in early cellular adhesion and sensory neuronal differentiation processes and is located to several sensory cilia in vivo. The use of zebrafish as a model organism allowed us to gain valuable knowledge on the physiological roles of App. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
| 653 | a Amyloid-beta precursor protein | |
| 653 | a amyloid precursor protein-b | |
| 653 | a zebrafish | |
| 653 | a physiological functions | |
| 653 | a development | |
| 653 | a trigeminal ganglia | |
| 653 | a ependyma | |
| 653 | a cilia | |
| 653 | a proteomics | |
| 653 | a translational adaptation | |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/308886 |
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