SwePub
Sök i LIBRIS databas

  Utökad sökning

L773:2197 7364
 

Sökning: L773:2197 7364 > Evaluation of zero-...

  • Sousa, João M.Uppsala universitet,Radiologi,Uppsala Univ Hosp, PET Ctr, Uppsala, Sweden (författare)

Evaluation of zero-echo-time attenuation correction for integrated PET/MR brain imaging-comparison to head atlas and 68Ge-transmission-based attenuation correction

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018-10-22
  • Springer Science and Business Media LLC,2018
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-364358
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-364358URI
  • https://doi.org/10.1186/s40658-018-0220-0DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: MRI does not offer a direct method to obtain attenuation correction maps as its predecessors (stand-alone PET and PET/CT), and bone visualisation is particularly challenging. Recently, zero-echo-time (ZTE) was suggested for MR-based attenuation correction (AC). The aim of this work was to evaluate ZTE- and atlas-AC by comparison to 68Ge-transmission scan-based AC.Nine patients underwent brain PET/MR and stand-alone PET scanning using the dopamine transporter ligand 11C-PE2I. For each of them, two AC maps were obtained from the MR images: an atlas-based, obtained from T1-weighted LAVA-FLEX imaging with cortical bone inserted using a CT-based atlas, and an AC map generated from proton-density-weighted ZTE images. Stand-alone PET 68Ge-transmission AC map was used as gold standard. PET images were reconstructed using the three AC methods and standardised uptake value (SUV) values for the striatal, limbic and cortical regions, as well as the cerebellum (VOIs) were compared. SUV ratio (SUVR) values normalised for the cerebellum were also assessed. Bias, precision and agreement were calculated; statistical significance was evaluated using Wilcoxon matched-pairs signed-rank test.Results: Both ZTE- and atlas-AC showed a similar bias of 6–8% in SUV values across the regions. Correlation coefficients with 68Ge-AC were consistently high for ZTE-AC (r 0.99 for all regions), whereas they were lower for atlas-AC, varying from 0.99 in the striatum to 0.88 in the posterior cortical regions. SUVR showed an overall bias of 2.9 and 0.5% for atlas-AC and ZTE-AC, respectively. Correlations with 68Ge-AC were higher for ZTE-AC, varying from 0.99 in the striatum to 0.96 in the limbic regions, compared to atlas-AC (0.99 striatum to 0.77 posterior cortex).Conclusions: Absolute SUV values showed less variability for ZTE-AC than for atlas-AC when compared to 68Ge-AC, but bias was similar for both methods. This bias is largely caused by higher linear attenuation coefficients in atlas- and ZTE-AC image compared to 68Ge-images. For SUVR, bias was lower when using ZTE-AC than for atlas-AC. ZTE-AC shows to be a more robust technique than atlas-AC in terms of both intra- and inter-patient variability.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Appel, LieuweUppsala universitet,Radiologi,Uppsala Univ Hosp, Med Imaging Ctr, Uppsala, Sweden(Swepub:uu)lap02157 (författare)
  • Engström, MathiasGE Healthcare, MR Appl Sci Lab, Waukesha, WI USA (författare)
  • Papadimitriou, StergiosUppsala universitet,Neurologi (författare)
  • Nyholm, DagUppsala universitet,Neurologi(Swepub:uu)danyh856 (författare)
  • Larsson, Elna-MarieUppsala universitet,Radiologi,Uppsala Univ Hosp, Med Imaging Ctr, Uppsala, Sweden(Swepub:uu)elnla305 (författare)
  • Ahlström, Håkan,1953-Uppsala universitet,Radiologi,Uppsala Univ Hosp, Med Imaging Ctr, Uppsala, Sweden(Swepub:uu)hakanahl (författare)
  • Lubberink, MarkUppsala universitet,Radiologi,Uppsala Univ Hosp, Dept Med Phys, Uppsala, Sweden(Swepub:uu)marklubb (författare)
  • Uppsala universitetRadiologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:EJNMMI Physics: Springer Science and Business Media LLC5:202197-7364

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy