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Search: WFRF:(Amos K.) > The causal relevanc...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003738naa a2200625 4500
001oai:DiVA.org:umu-129402
003SwePub
008161227s2016 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1294022 URI
0247 a https://doi.org/10.1038/srep311212 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Carreras-Torres, Robert4 aut
2451 0a The causal relevance of body mass index in different histological types of lung cancer :b a Mendelian randomization study
264 c 2016-08-04
264 1b Nature Publishing Group,c 2016
338 a print2 rdacarrier
520 a Body mass index (BMI) is inversely associated with lung cancer risk in observational studies, even though it increases the risk of several other cancers, which could indicate confounding by tobacco smoking or reverse causality. We used the two-sample Mendelian randomization (MR) approach to circumvent these limitations of observational epidemiology by constructing a genetic instrument for BMI, based on results from the GIANT consortium, which was evaluated in relation to lung cancer risk using GWAS results on 16,572 lung cancer cases and 21,480 controls. Results were stratified by histological subtype, smoking status and sex. An increase of one standard deviation (SD) in BMI (4.65 Kg/m(2)) raised the risk for lung cancer overall (OR = 1.13; P = 0.10). This was driven by associations with squamous cell (SQ) carcinoma (OR = 1.45; P = 1.2 × 10(-3)) and small cell (SC) carcinoma (OR = 1.81; P = 0.01). An inverse trend was seen for adenocarcinoma (AD) (OR = 0.82; P = 0.06). In stratified analyses, a 1 SD increase in BMI was inversely associated with overall lung cancer in never smokers (OR = 0.50; P = 0.02). These results indicate that higher BMI may increase the risk of certain types of lung cancer, in particular SQ and SC carcinoma.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Haycock, Philip C4 aut
7001 a Relton, Caroline L4 aut
7001 a Martin, Richard M4 aut
7001 a Smith, George Davey4 aut
7001 a Kraft, Peter4 aut
7001 a Gao, Chi4 aut
7001 a Tworoger, Shelley4 aut
7001 a Le Marchand, Loïc4 aut
7001 a Wilkens, Lynne R4 aut
7001 a Park, Sungshim L4 aut
7001 a Haiman, Christopher4 aut
7001 a Field, John K4 aut
7001 a Davies, Michael4 aut
7001 a Marcus, Michael4 aut
7001 a Liu, Geoffrey4 aut
7001 a Caporaso, Neil E4 aut
7001 a Christiani, David C4 aut
7001 a Wei, Yongyue4 aut
7001 a Chen, Chu4 aut
7001 a Doherty, Jennifer A4 aut
7001 a Severi, Gianluca4 aut
7001 a Goodman, Gary E4 aut
7001 a Hung, Rayjean J4 aut
7001 a Amos, Christopher I4 aut
7001 a McKay, James4 aut
7001 a Johansson, Mattiasu Section of Genetics, International Agency for Research on Cancer (IARC), Lyon, France4 aut0 (Swepub:umu)masmas97
7001 a Brennan, Paul4 aut
7102 a Section of Genetics, International Agency for Research on Cancer (IARC), Lyon, France4 org
7730 t Scientific Reportsd : Nature Publishing Groupg 6q 6x 2045-2322
8564 u https://www.nature.com/articles/srep31121.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-129402
8564 8u https://doi.org/10.1038/srep31121

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