onr:"swepub:oai:prod.swepub.kib.ki.se:149571252"
Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:149571252" > MAIT cell compartme...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03311naa a2200493 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:149571252 | |
| 003 | SwePub | |
| 008 | 240913s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1495712522 URI |
| 024 | 7 | a https://doi.org/10.1186/s10020-022-00484-72 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Boulouis, Cu Karolinska Institutet4 aut |
| 245 | 1 0 | a MAIT cell compartment characteristics are associated with the immune response magnitude to the BNT162b2 mRNA anti-SARS-CoV-2 vaccine |
| 264 | c 2022-05-13 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2022 |
| 520 | a Mucosa-associated invariant T (MAIT) cells are unconventional T cells with innate-like capacity to rapidly respond to microbial infection via MR1-restricted antigen recognition. Emerging evidence indicate that they can also act as rapid sensors of viral infection via innate cytokine activation. However, their possible role in the immune response to mRNA vaccination is unknown. Here, we evaluated the involvement of MAIT cells in individuals vaccinated with the BNT162b2 mRNA SARS-CoV-2 vaccine. MAIT cell levels, phenotype and function in circulation were preserved and unperturbed through day 35 post-vaccination in healthy donor (HD) vaccinees, as well as people living with HIV (PLWH) or with primary immunodeficiency (PID). Unexpectedly, pre-vaccination and post-vaccination levels of MAIT cells correlated positively with the magnitude of the SARS-CoV-2 spike protein-specific CD4 T cell and antibody responses in the HD vaccinees. This pattern was largely preserved in the PID group, but less so in the PLWH group. Furthermore, in the HD vaccinees levels of MAIT cell activation and cytolytic potential correlated negatively to the adaptive antigen-specific immune responses. These findings indicate an unexpected association between MAIT cell compartment characteristics and the immune response magnitude to the BNT162b2 mRNA vaccine. | |
| 700 | 1 | a Kammann, Tu Karolinska Institutet4 aut |
| 700 | 1 | a Cuapio, A4 aut |
| 700 | 1 | a Parrot, T4 aut |
| 700 | 1 | a Gao, Y4 aut |
| 700 | 1 | a Mouchtaridi, E4 aut |
| 700 | 1 | a Wullimann, D4 aut |
| 700 | 1 | a Lange, J4 aut |
| 700 | 1 | a Chen, P4 aut |
| 700 | 1 | a Akber, M4 aut |
| 700 | 1 | a Ballesteros, OR4 aut |
| 700 | 1 | a Muvva, JR4 aut |
| 700 | 1 | a Smith, CIEu Karolinska Institutet4 aut |
| 700 | 1 | a Vesterbacka, Ju Karolinska Institutet4 aut |
| 700 | 1 | a Kieri, Ou Karolinska Institutet4 aut |
| 700 | 1 | a Nowak, Pu Karolinska Institutet4 aut |
| 700 | 1 | a Bergman, Pu Karolinska Institutet4 aut |
| 700 | 1 | a Buggert, Mu Karolinska Institutet4 aut |
| 700 | 1 | a Ljunggren, HGu Karolinska Institutet4 aut |
| 700 | 1 | a Aleman, Su Karolinska Institutet4 aut |
| 700 | 1 | a Sandberg, JKu Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Molecular medicine (Cambridge, Mass.)d : Springer Science and Business Media LLCg 28:1, s. 54-q 28:1<54-x 1528-3658x 1076-1551 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:149571252 |
| 856 | 4 8 | u https://doi.org/10.1186/s10020-022-00484-7 |
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- Boulouis, C
- Kammann, T
- Cuapio, A
- Parrot, T
- Gao, Y
- Mouchtaridi, E
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- Wullimann, D
- Lange, J
- Chen, P
- Akber, M
- Ballesteros, OR
- Muvva, JR
- Smith, CIE
- Vesterbacka, J
- Kieri, O
- Nowak, P
- Bergman, P
- Buggert, M
- Ljunggren, HG
- Aleman, S
- Sandberg, JK
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