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Humanistic outcomes...
Humanistic outcomes in treatment resistant depression : a secondary analysis of the STAR*D study
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- DiBernardo, Allitia (författare)
- Janssen Res & Dev LLC, Titusville, NJ 08560 USA
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- Lin, Xiwu (författare)
- Janssen Res & Dev LLC, Titusville, NJ 08560 USA
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- Zhang, Qiaoyi (författare)
- Janssen Res & Dev LLC, Titusville, NJ 08560 USA
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- Xiang, Jim (författare)
- Janssen Res & Dev LLC, Titusville, NJ 08560 USA
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- Lu, Lang (författare)
- Karolinska Institutet,Janssen Res & Dev LLC, Titusville, NJ 08560 USA
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- Jamieson, Carol (författare)
- Janssen Res & Dev LLC, Titusville, NJ 08560 USA
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- Benson, Carmela (författare)
- Janssen Sci Affairs LLC, Titusville, NJ USA
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- Lee, Kwan (författare)
- Janssen Res & Dev LLC, Titusville, NJ 08560 USA
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- Bodén, Robert, 1973- (författare)
- Uppsala universitet,Psykiatri, Akademiska sjukhuset,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Ctr Pharmacoepidemiol Clin Epidemiol, Stockholm, Sweden
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- Brandt, Lena (författare)
- Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Ctr Pharmacoepidemiol Clin Epidemiol, Stockholm, Sweden
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- Brenner, Philip (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Ctr Pharmacoepidemiol Clin Epidemiol, Stockholm, Sweden
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- Reutfors, Johan (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Ctr Pharmacoepidemiol Clin Epidemiol, Stockholm, Sweden
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- Li, Gang (författare)
- Janssen Res & Dev LLC, Titusville, NJ 08560 USA;Janssen R&D US, Real World Evidence Stat & Decis Sci, 920 US Highway 202 S, Raritan, NJ 08869 USA
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(creator_code:org_t)
- 2018-10-29
- 2018
- Engelska.
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Ingår i: BMC Psychiatry. - : BMC. - 1471-244X. ; 18
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://bmcpsychiatr...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BackgroundIn the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, a third of patients did not achieve remission or adequate response after two treatment trials, fulfilling requirements for treatment resistant depression (TRD). The present study is a secondary analysis of the STAR*D data conducted to compare the humanistic outcomes in patients with TRD and non-TRD MDD.MethodsPatients with major depressive disorder who entered level 3 of the STAR*D were included in the TRD group, while patients who responded to treatment and entered follow-up from level 1 or 2 were included in the non-TRD group. The first visit in level 1 was used for baseline assessments. The time-point of assessments for comparison was the first visit in level 3 for TRD patients (median day: 141), and the visit closest to 14160days from baseline for non-TRD patients. Outcomes were assessed by the 12-item Short Form Health Survey (SF12), 16-item Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Work and Social Adjustment Scale (WSAS), and Work Productivity and Activity Impairment scale (WPAI). Scores were compared in a linear model with adjustment for covariates including age, gender, and depression severity measured by the 17-item Hamilton Rating Scale for Depression (HDRS17) and Quick Inventory of Depressive Symptomatology (QIDS).ResultsA total of 2467 (TRD: 377; non-TRD: 2090) patients were studied. TRD patients were slightly older (mean age 44 vs 42years), had a higher proportion of men (49% vs 37%, p<.0001), and baseline depression severity (HDRS17: 24.4 vs 22.0, p<.0001) vs non-TRD patients. During follow-up, TRD patients had lower health-related quality of life (HRQOL) scores on mental (30 vs 45.7) and physical components (47.7 vs 48.9) of the SF12, and lower Q-LES-Q scores (43.6 vs 63.7), greater functional and work impairments and productivity loss vs non-TRD patients (all p<0.05).Conclusion Patients with TRD had worse HRQOL, work productivity, and social functioning than the non-TRD patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Health-related quality of life
- Humanistic outcomes
- Social functioning
- Star*d
- Treatment resistant depression
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- Av författaren/redakt...
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DiBernardo, Alli ...
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Lin, Xiwu
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Zhang, Qiaoyi
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Xiang, Jim
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Lu, Lang
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Jamieson, Carol
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visa fler...
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Benson, Carmela
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Lee, Kwan
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Bodén, Robert, 1 ...
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Brandt, Lena
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Brenner, Philip
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Reutfors, Johan
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Li, Gang
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
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BMC Psychiatry
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Uppsala universitet
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Karolinska Institutet