Sökning: WFRF:(Curtin C) > A novel common vari...
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000 | 09769naa a2202161 4500 | |
001 | oai:gup.ub.gu.se/261471 | |
003 | SwePub | |
008 | 240910s2015 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:miun-24414 | |
009 | oai:prod.swepub.kib.ki.se:130808568 | |
024 | 7 | a https://gup.ub.gu.se/publication/2614712 URI |
024 | 7 | a https://doi.org/10.1093/hmg/ddu5102 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-244142 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1308085682 URI |
040 | a (SwePub)gud (SwePub)miund (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a van der Valk, Ralf J P4 aut |
245 | 1 0 | a A novel common variant in DCST2 is associated with length in early life and height in adulthood. |
264 | c 2014-10-03 | |
264 | 1 | b Oxford University Press (OUP),c 2015 |
520 | a Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 × 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; β = 0.046, SE = 0.008, P = 2.46 × 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 × 10(-4)) and adult height (N = 127 513; P = 1.45 × 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a SAMHÄLLSVETENSKAPx Psykologi0 (SwePub)5012 hsv//swe |
650 | 7 | a SOCIAL SCIENCESx Psychology0 (SwePub)5012 hsv//eng |
653 | a Adaptor Proteins | |
653 | a Signal Transducing | |
653 | a genetics | |
653 | a metabolism | |
653 | a Adult | |
653 | a Age Factors | |
653 | a Alleles | |
653 | a Body Height | |
653 | a genetics | |
653 | a Computational Biology | |
653 | a Databases | |
653 | a Genetic | |
653 | a Genetic Association Studies | |
653 | a Genetic Variation | |
653 | a Genotype | |
653 | a Humans | |
653 | a Infant | |
653 | a Newborn | |
653 | a Membrane Proteins | |
653 | a genetics | |
653 | a metabolism | |
653 | a Phenotype | |
653 | a Polymorphism | |
653 | a Single Nucleotide | |
653 | a Quantitative Trait Loci | |
653 | a Quantitative Trait | |
653 | a Heritable | |
653 | a Reproducibility of Results | |
700 | 1 | a Kreiner-Møller, Eskil4 aut |
700 | 1 | a Kooijman, Marjolein N4 aut |
700 | 1 | a Guxens, Mònica4 aut |
700 | 1 | a Stergiakouli, Evangelia4 aut |
700 | 1 | a Sääf, Annika4 aut |
700 | 1 | a Bradfield, Jonathan P4 aut |
700 | 1 | a Geller, Frank4 aut |
700 | 1 | a Hayes, M Geoffrey4 aut |
700 | 1 | a Cousminer, Diana L4 aut |
700 | 1 | a Körner, Antje4 aut |
700 | 1 | a Thiering, Elisabeth4 aut |
700 | 1 | a Curtin, John A4 aut |
700 | 1 | a Myhre, Ronny4 aut |
700 | 1 | a Huikari, Ville4 aut |
700 | 1 | a Joro, Raimo4 aut |
700 | 1 | a Kerkhof, Marjan4 aut |
700 | 1 | a Warrington, Nicole M4 aut |
700 | 1 | a Pitkänen, Niina4 aut |
700 | 1 | a Ntalla, Ioanna4 aut |
700 | 1 | a Horikoshi, Momoko4 aut |
700 | 1 | a Veijola, Riitta4 aut |
700 | 1 | a Freathy, Rachel M4 aut |
700 | 1 | a Teo, Yik-Ying4 aut |
700 | 1 | a Barton, Sheila J4 aut |
700 | 1 | a Evans, David Mu Karolinska Institutet4 aut |
700 | 1 | a Kemp, John P4 aut |
700 | 1 | a St Pourcain, Beate4 aut |
700 | 1 | a Ring, Susan M4 aut |
700 | 1 | a Davey Smith, George4 aut |
700 | 1 | a Bergström, Annau Karolinska Institutet4 aut |
700 | 1 | a Kull, Ingeru Karolinska Institutet4 aut |
700 | 1 | a Hakonarson, Hakon4 aut |
700 | 1 | a Mentch, Frank D4 aut |
700 | 1 | a Bisgaard, Hans4 aut |
700 | 1 | a Chawes, Bo4 aut |
700 | 1 | a Stokholm, Jakob4 aut |
700 | 1 | a Waage, Johannes4 aut |
700 | 1 | a Eriksen, Patrick4 aut |
700 | 1 | a Sevelsted, Astrid4 aut |
700 | 1 | a Melbye, Mads4 aut |
700 | 1 | a van Duijn, Cornelia M4 aut |
700 | 1 | a Medina-Gomez, Carolina4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a de Jongste, Johan C4 aut |
700 | 1 | a Taal, H Rob4 aut |
700 | 1 | a Uitterlinden, André G4 aut |
700 | 1 | a Armstrong, Loren L4 aut |
700 | 1 | a Eriksson, Johan4 aut |
700 | 1 | a Palotie, Aarno4 aut |
700 | 1 | a Bustamante, Mariona4 aut |
700 | 1 | a Estivill, Xavier4 aut |
700 | 1 | a Gonzalez, Juan R4 aut |
700 | 1 | a Llop, Sabrina4 aut |
700 | 1 | a Kiess, Wieland4 aut |
700 | 1 | a Mahajan, Anubha4 aut |
700 | 1 | a Flexeder, Claudia4 aut |
700 | 1 | a Tiesler, Carla M T4 aut |
700 | 1 | a Murray, Clare S4 aut |
700 | 1 | a Simpson, Angela4 aut |
700 | 1 | a Magnus, Per4 aut |
700 | 1 | a Sengpiel, Verena,d 1977u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xsenve |
700 | 1 | a Hartikainen, Anna-Liisa4 aut |
700 | 1 | a Keinanen-Kiukaanniemi, Sirkka4 aut |
700 | 1 | a Lewin, Alexandra4 aut |
700 | 1 | a Da Silva Couto Alves, Alexessander4 aut |
700 | 1 | a Blakemore, Alexandra I4 aut |
700 | 1 | a Buxton, Jessica L4 aut |
700 | 1 | a Kaakinen, Marika4 aut |
700 | 1 | a Rodriguez, Alinau Mittuniversitetet,Avdelningen för psykologi4 aut0 (Swepub:miun)alirod |
700 | 1 | a Sebert, Sylvain4 aut |
700 | 1 | a Vaarasmaki, Marja4 aut |
700 | 1 | a Lakka, Timo4 aut |
700 | 1 | a Lindi, Virpi4 aut |
700 | 1 | a Gehring, Ulrike4 aut |
700 | 1 | a Postma, Dirkje S4 aut |
700 | 1 | a Ang, Wei4 aut |
700 | 1 | a Newnham, John P4 aut |
700 | 1 | a Lyytikäinen, Leo-Pekka4 aut |
700 | 1 | a Pahkala, Katja4 aut |
700 | 1 | a Raitakari, Olli T4 aut |
700 | 1 | a Panoutsopoulou, Kalliope4 aut |
700 | 1 | a Zeggini, Eleftheria4 aut |
700 | 1 | a Boomsma, Dorret I4 aut |
700 | 1 | a Groen-Blokhuis, Maria4 aut |
700 | 1 | a Ilonen, Jorma4 aut |
700 | 1 | a Franke, Lude4 aut |
700 | 1 | a Hirschhorn, Joel N4 aut |
700 | 1 | a Pers, Tune H4 aut |
700 | 1 | a Liang, Liming4 aut |
700 | 1 | a Huang, Jinyan4 aut |
700 | 1 | a Hocher, Berthold4 aut |
700 | 1 | a Knip, Mikael4 aut |
700 | 1 | a Saw, Seang-Mei4 aut |
700 | 1 | a Holloway, John W4 aut |
700 | 1 | a Melén, Erik4 aut |
700 | 1 | a Grant, Struan F A4 aut |
700 | 1 | a Feenstra, Bjarke4 aut |
700 | 1 | a Lowe, William L4 aut |
700 | 1 | a Widén, Elisabeth4 aut |
700 | 1 | a Sergeyev, Elena4 aut |
700 | 1 | a Grallert, Harald4 aut |
700 | 1 | a Custovic, Adnan4 aut |
700 | 1 | a Jacobsson, Bo,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xjacbo |
700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
700 | 1 | a Atalay, Mustafa4 aut |
700 | 1 | a Koppelman, Gerard H4 aut |
700 | 1 | a Pennell, Craig E4 aut |
700 | 1 | a Niinikoski, Harri4 aut |
700 | 1 | a Dedoussis, George V4 aut |
700 | 1 | a Mccarthy, Mark I4 aut |
700 | 1 | a Frayling, Timothy M4 aut |
700 | 1 | a Sunyer, Jordi4 aut |
700 | 1 | a Timpson, Nicholas J4 aut |
700 | 1 | a Rivadeneira, Fernando4 aut |
700 | 1 | a Bønnelykke, Klaus4 aut |
700 | 1 | a Jaddoe, Vincent W V4 aut |
710 | 2 | a Karolinska Institutetb Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi4 org |
773 | 0 | t Human molecular geneticsd : Oxford University Press (OUP)g 24:4, s. 1155-68q 24:4<1155-68x 1460-2083x 0964-6906 |
856 | 4 | u https://academic.oup.com/hmg/article-pdf/24/4/1155/14144121/ddu510.pdf |
856 | 4 | u https://doi.org/10.1093/hmg/ddu510y Fulltext |
856 | 4 | u https://miun.diva-portal.org/smash/get/diva2:790291/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://gup.ub.gu.se/publication/261471 |
856 | 4 8 | u https://doi.org/10.1093/hmg/ddu510 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-24414 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:130808568 |
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