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Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans.
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- Waluk, Dominik P., 1983- (author)
- Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi
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- Schultz, Niklas (author)
- Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi
- Hunt, Mary C. (author)
- (creator_code:org_t)
- 2010-03-19
- 2010
- English.
- In: The FASEB Journal. - : Wiley. - 0892-6638 .- 1530-6860. ; 24:8, s. 2795-2803
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The discovery of glycine conjugates of long-chain fatty acids (N-acyl glycines) in the brain and other non-neuronal tissues has led to the identification of an emerging class of bioactive lipids. The biological activities of N-acyl glycines include antinociceptive, anti-inflammatory and antiproliferative effects, and activation of G-protein-coupled receptors. However, despite the fact that N-acyl glycines are emerging as a distinct lipid signaling family, pathways for their production are not fully elucidated. Here we report on the characterization of human glycine N-acyltransferase-like 2 (hGLYATL2), a member of a gene family of 4 putative glycine conjugating enzymes, and show that it synthesizes various N-acyl glycines. Recombinantly expressed hGLYATL2 efficiently conjugated oleoyl-CoA, arachidonoyl-CoA, and other medium- and long-chain acyl-CoAs to glycine. The enzyme was specific for glycine as an acceptor molecule, and preferentially produced N-oleoyl glycine. The hGLYATL2 enzyme is localized to the endoplasmic reticulum, and the mRNA shows highest expression in salivary gland and trachea, but is also detected in spinal cord and skin fibroblasts. The expression pattern and the identification of high levels of N-acyl glycines in skin and lung may indicate a role for N-acyl glycines in barrier function/immune response and the potential role of hGLYATL2 in this regard is discussed.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- N-oleoyl glycine
- N-arachidonoyl glycine
- endocannabinoids
- N-acyl amino acids
- endoplasmic reticulum
- Biochemistry
- biokemi
- Molecular Cellbiology
- molekylär cellbiologi
- molekylärgenetik
- Molecular Genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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