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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003323naa a2200373 4500
001oai:prod.swepub.kib.ki.se:121655056
003SwePub
008240811s2010 | |||||||||||000 ||eng|
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1216550562 URI
0247 a https://doi.org/10.1186/1744-8069-6-802 DOI
040 a (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Zyloney, CE4 aut
2451 0a Imaging the functional connectivity of the Periaqueductal Gray during genuine and sham electroacupuncture treatment
264 c 2010-01-01
264 1b SAGE Publications,c 2010
520 a Electroacupuncture (EA) is currently one of the most popular acupuncture modalities. However, the continuous stimulation characteristic of EA treatment presents challenges to the use of conventional functional Magnetic Resonance Imaging (fMRI) approaches for the investigation of neural mechanisms mediating treatment response because of the requirement for brief and intermittent stimuli in event related or block designed task paradigms. A relatively new analysis method, functional connectivity fMRI (fcMRI), has great potential for studying continuous treatment modalities such as EA. In a previous study, we found that, compared with sham acupuncture, EA can significantly reduce Periaqueductal Gray (PAG) activity when subsequently evoked by experimental pain. Given the PAG's important role in mediating acupuncture analgesia, in this study we investigated functional connectivity with the area of the PAG we previously identified and how that connectivity was affected by genuine and sham EA. Results: Forty-eight subjects, who were randomly assigned to receive either genuine or sham EA paired with either a high or low expectancy manipulation, completed the study. Direct comparison of each treatment mode's functional connectivity revealed: significantly greater connectivity between the PAG, left posterior cingulate cortex (PCC), and precuneus for the contrast of genuine minus sham; significantly greater connectivity between the PAG and right anterior insula for the contrast of sham minus genuine; no significant differences in connectivity between different contrasts of the two expectancy levels. Conclusions: Our findings indicate the intrinsic functional connectivity changes among key brain regions in the pain matrix and default mode network during genuine EA compared with sham EA. We speculate that continuous genuine EA stimulation can modify the coupling of spontaneous activity in brain regions that play a role in modulating pain perception.
7001 a Jensen, Ku Karolinska Institutet4 aut
7001 a Polich, G4 aut
7001 a Loiotile, RE4 aut
7001 a Cheetham, A4 aut
7001 a LaViolette, PS4 aut
7001 a Tu, PC4 aut
7001 a Kaptchuk, TJ4 aut
7001 a Gollub, RL4 aut
7001 a Kong, JA4 aut
7102 a Karolinska Institutet4 org
7730 t Molecular paind : SAGE Publicationsg 6, s. 80-q 6<80-x 1744-8069
8564 u https://journals.sagepub.com/doi/pdf/10.1186/1744-8069-6-80
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:121655056
8564 8u https://doi.org/10.1186/1744-8069-6-80

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