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WFRF:(Larsson Tobias E)
 

Sökning: WFRF:(Larsson Tobias E) > Fibroblast growth f...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006908naa a2200697 4500
001oai:gup.ub.gu.se/176311
003SwePub
008240910s2013 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:9e56f275-98b4-44c3-bb63-020af7df502c
009oai:prod.swepub.kib.ki.se:126712925
009oai:DiVA.org:uu-188146
0247 a https://gup.ub.gu.se/publication/1763112 URI
0247 a https://doi.org/10.1186/1471-2369-14-852 DOI
0247 a https://lup.lub.lu.se/record/38155092 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1267129252 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1881462 URI
040 a (SwePub)gud (SwePub)lud (SwePub)kid (SwePub)uu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Westerberg, Per-Antonu Uppsala universitet,Njurmedicin4 aut0 (Swepub:uu)perwe432
2451 0a Fibroblast growth factor 23, mineral metabolism and mortality among elderly men (Swedish MrOs).
264 c 2013-04-15
264 1b Springer Science and Business Media LLC,c 2013
338 a electronic2 rdacarrier
520 a BACKGROUND: Fibroblast growth factor 23 (FGF23) is the earliest marker of disturbed mineral metabolism as renal function decreases. Its serum levels are associated with mortality in dialysis patients, persons with chronic kidney disease (CKD) and prevalent cardiovascular disease (CVD), and it is associated with atherosclerosis, endothelial dysfunction and left ventricular hypertrophy in the general population. The primary aim of this study is to examine the association between FGF23 and mortality, in relation to renal function in the community. A secondary aim is to examine the association between FGF23 and CVD related death. METHODS: The population-based cohort of MrOS Sweden included 3014 men (age 69--81 years). At inclusion intact FGF23, intact parathyroid hormone (PTH), 25 hydroxyl vitamin D (25D), calcium and phosphate were measured. Mortality data were collected after an average of 4.5 years follow-up. 352 deaths occurred, 132 of CVD. Association between FGF23 and mortality was analyzed in quartiles of FGF23. Kaplan-Meier curves and Log-rank test were used to examine time to events. Cox proportional hazards regression was used to examine the association between FGF23, in quartiles and as a continuous variable, with mortality. The associations were also analyzed in the sub-cohort with estimated glomerular filtration rate (eGFR) above 60 ml/min/1.73 m2. RESULTS: There was no association between FGF23 and all-cause mortality, Hazard ratio (HR) 95% confidence interval (CI): 1.02 (0.89-1.17). For CVD death the HR (95% CI) was 1.26 (0.99 - 1.59)/(1-SD) increase in log(10)FGF23 after adjustment for eGFR, and other confounders. In the sub-cohort with eGFR > 60 ml/min/1.73 m2 the HR (95% CI) for CVD death was 55% (13--111)/(1-SD) increase in log(10)FGF23 CONCLUSIONS: FGF23 is not associated with mortality of all-cause in elderly community living men, but there is a weak association with CVD death, even after adjustment for eGFR and the other confounders. The association with CVD death is noticeable only in the sub-cohort with preserved renal function.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653 a FGF-23
653 a FGF23
653 a Mineral metabolism
653 a Phosphatonin
653 a Mortality
653 a Elderly
653 a FGF23
653 a Medicin
7001 a Tivesten, Åsa,d 1969u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,Wallenberg Laboratory for Cardiovascular Research, University of Göteborg, Göteborg,4 aut0 (Swepub:gu)xtivas
7001 a Karlsson, Magnusu Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences and Orthopedic Surgery, Lund University, Skåne University Hospital, Sweden.4 aut0 (Swepub:lu)orto-mka
7001 a Mellström, Dan,d 1945u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Center for Bone and Arthritis Research at the Sahlgrenska Academy, Institute of Medicine, the Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.4 aut0 (Swepub:gu)xmelda
7001 a Orwoll, Ericu Oregon Health and Science University, Portland, Oregon, USA.4 aut
7001 a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Center for Bone and Arthritis Research at the Sahlgrenska Academy, Institute of Medicine, the Sahlgrenska Academy at Göteborg University, Göteborg, Sweden4 aut0 (Swepub:gu)xohlcl
7001 a Larsson, Tobias Eu Karolinska Institutet,Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm,4 aut
7001 a Linde, Torbjörnu Uppsala universitet,Njurmedicin4 aut0 (Swepub:uu)torblind
7001 a Ljunggren, Östenu Uppsala universitet,Metabola bensjukdomar4 aut0 (Swepub:uu)osteljun
7102 a Uppsala universitetb Njurmedicin4 org
7730 t BMC nephrologyd : Springer Science and Business Media LLCg 14:1q 14:1x 1471-2369
8564 u https://gup.ub.gu.se/publication/176311x primaryx freey FULLTEXT
8564 u https://bmcnephrol.biomedcentral.com/track/pdf/10.1186/1471-2369-14-85
8564 u https://portal.research.lu.se/files/3267939/4153305.pdfx primaryx freey FULLTEXT
8564 u http://dx.doi.org/10.1186/1471-2369-14-85x freey FULLTEXT
8564 u https://uu.diva-portal.org/smash/get/diva2:576369/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://gup.ub.gu.se/publication/176311
8564 8u https://doi.org/10.1186/1471-2369-14-85
8564 8u https://lup.lub.lu.se/record/3815509
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:126712925
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-188146

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