SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Pearson Robert)
 

Sökning: WFRF:(Pearson Robert) > Post-load glucose s...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008479naa a2200817 4500
001oai:lup.lub.lu.se:5122f7f3-ccf3-49b6-ba5b-e88f3459ee7e
003SwePub
008201214s2020 | |||||||||||000 ||eng|
009oai:DiVA.org:kth-289936
0247 a https://lup.lub.lu.se/record/5122f7f3-ccf3-49b6-ba5b-e88f3459ee7e2 URI
0247 a https://doi.org/10.1371/journal.pone.02423602 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2899362 URI
040 a (SwePub)lud (SwePub)kth
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Obura, Morganu Academic Medical Center of University of Amsterdam (AMC),Amsterdam UMC - Vrije Universiteit Amsterdam,Amsterdam Univ Med Ctr, Locat VU Univ Med Ctr, Amsterdam Publ Hlth Res Inst, Epidemiol & Data Sci, Amsterdam, Netherlands.4 aut
2451 0a Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes : An IMI-DIRECT study
264 c 2020-11-30
264 1b Public Library of Science (PLoS),c 2020
500 a QC 20210211
520 a AIM: Subclasses of different glycaemic disturbances could explain the variation in characteristics of individuals with type 2 diabetes (T2D). We aimed to examine the association between subgroups based on their glucose curves during a five-point mixed-meal tolerance test (MMT) and metabolic traits at baseline and glycaemic deterioration in individuals with T2D. METHODS: The study included 787 individuals with newly diagnosed T2D from the Diabetes Research on Patient Stratification (IMI-DIRECT) Study. Latent class trajectory analysis (LCTA) was used to identify distinct glucose curve subgroups during a five-point MMT. Using general linear models, these subgroups were associated with metabolic traits at baseline and after 18 months of follow up, adjusted for potential confounders. RESULTS: At baseline, we identified three glucose curve subgroups, labelled in order of increasing glucose peak levels as subgroup 1-3. Individuals in subgroup 2 and 3 were more likely to have higher levels of HbA1c, triglycerides and BMI at baseline, compared to those in subgroup 1. At 18 months (n = 651), the beta coefficients (95% CI) for change in HbA1c (mmol/mol) increased across subgroups with 0.37 (-0.18-1.92) for subgroup 2 and 1.88 (-0.08-3.85) for subgroup 3, relative to subgroup 1. The same trend was observed for change in levels of triglycerides and fasting glucose. CONCLUSIONS: Different glycaemic profiles with different metabolic traits and different degrees of subsequent glycaemic deterioration can be identified using data from a frequently sampled mixed-meal tolerance test in individuals with T2D. Subgroups with the highest peaks had greater metabolic risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Beulens, Joline W.J.u Academic Medical Center of University of Amsterdam (AMC),Amsterdam UMC - Vrije Universiteit Amsterdam,University Medical Center Utrecht,Amsterdam Univ Med Ctr, Locat VU Univ Med Ctr, Amsterdam Publ Hlth Res Inst, Epidemiol & Data Sci, Amsterdam, Netherlands.;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.4 aut
7001 a Slieker, Rodericku Leiden University Medical Centre,Amsterdam UMC - Vrije Universiteit Amsterdam,Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Koopman, Anitra D.M.u Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Hoekstra, Trynkeu Amsterdam UMC - Vrije Universiteit Amsterdam,Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Nijpels, Gielu Academic Medical Center of University of Amsterdam (AMC),Amsterdam UMC - Vrije Universiteit Amsterdam4 aut
7001 a Elders, Petrau Amsterdam UMC - Vrije Universiteit Amsterdam,Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Koivula, Robert W.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,University of Oxford4 aut0 (Swepub:lu)med-rkl
7001 a Kurbasic, Azrau Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)mats-aku
7001 a Laakso, Markkuu University of Eastern Finland,Kuopio University Hospital4 aut
7001 a Hansen, Tue H.u University of Copenhagen,Slagelse Hospital4 aut
7001 a Ridderstråle, Martinu University of Copenhagen4 aut0 (Swepub:lu)endo-mri
7001 a Hansen, Torbenu University of Copenhagen,University of Southern Denmark4 aut
7001 a Pavo, Imreu Eli Lilly Regional Operations G.m.b.H.4 aut
7001 a Forgie, Ianu University of Dundee,Ninewells Hospital and Medical School4 aut
7001 a Jablonka, Berndu Sanofi-Aventis Deutschland GmbH4 aut
7001 a Ruetten, Hartmutu Sanofi-Aventis Deutschland GmbH4 aut
7001 a Mari, Andreau CNR Institute of Biomedical Engineering4 aut
7001 a McCarthy, Mark I.u University of Oxford,Wellcome Trust Centre for Human Genetics4 aut
7001 a Walker, Marku University of Newcastle upon Tyne4 aut
7001 a Heggie, Alisonu University of Newcastle upon Tyne4 aut
7001 a McDonald, Timothy J.u University of Exeter,Royal Devon and Exeter NHS Foundation Trust4 aut
7001 a Perry, Mandy H.u Royal Devon and Exeter NHS Foundation Trust4 aut
7001 a De Masi, Federicou Technical University of Denmark4 aut
7001 a Brunak, Sørenu University of Copenhagen,Technical University of Denmark4 aut
7001 a Mahajan, Anubhau Wellcome Trust Centre for Human Genetics4 aut
7001 a Giordano, Giuseppe N.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-geg
7001 a Kokkola, Tarjau Kuopio University Hospital,University of Eastern Finland4 aut
7001 a Dermitzakis, Emmanouilu University of Geneva,Swiss Institute for Bioinformatics (SIB)4 aut
7001 a Viñuela, Anau Swiss Institute for Bioinformatics (SIB),University of Geneva4 aut
7001 a Pedersen, Olufu University of Copenhagen4 aut
7001 a Schwenk, Jochen M.u KTH,KTH Royal Institute of Technology,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1h7wtme
7001 a Adamski, Jureku Technical University of Munich,National University of Singapore,Helmholtz Zentrum München,University of Oxford4 aut
7001 a Teare, Harriet J.A.u University of Oxford4 aut
7001 a Pearson, Ewan R.u University of Dundee4 aut
7001 a Franks, Paul W.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University,University of Oxford4 aut0 (Swepub:lu)med-plf
7001 a 't Hart, Leen M.u Leiden University Medical Centre,Amsterdam UMC - Vrije Universiteit Amsterdam,Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Rutters, Femkeu Academic Medical Center of University of Amsterdam (AMC),Amsterdam UMC - Vrije Universiteit Amsterdam,Amsterdam Univ Med Ctr, Locat VU Univ Med Ctr, Amsterdam Publ Hlth Res Inst, Epidemiol & Data Sci, Amsterdam, Netherlands.4 aut
7102 a Academic Medical Center of University of Amsterdam (AMC)b Amsterdam UMC - Vrije Universiteit Amsterdam4 org
7102 a IMI DIRECT Consortium
7730 t PLoS ONEd : Public Library of Science (PLoS)g 15:11q 15:11x 1932-6203
8564 u http://dx.doi.org/10.1371/journal.pone.0242360x freey FULLTEXT
8564 u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0242360&type=printable
8564 u https://doi.org/10.1371/journal.pone.0242360y Fulltext
8564 8u https://lup.lub.lu.se/record/5122f7f3-ccf3-49b6-ba5b-e88f3459ee7e
8564 8u https://doi.org/10.1371/journal.pone.0242360
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-289936

Hitta via bibliotek

  • PLoS ONE (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy