Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study.

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Fältnamn	Indikatorer	Metadata
000		07466naa a2201633 4500
001		oai:gup.ub.gu.se/322804
003		SwePub
008		240910s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:236408127
024	7	a https://gup.ub.gu.se/publication/3228042 URI
024	7	a https://doi.org/10.1159/0005197072 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:2364081272 URI
040		a (SwePub)gud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Coombes, Brandon J4 aut
245	1 0	a Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study.
264		c 2021-11-18
264	1	b S. Karger AG,c 2021
520		a Response to lithium varies widely between individuals with bipolar disorder (BD). Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (N = 2,510) with BD were assessed for long-term lithium response in the Consortium on Lithium Genetics using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. PRSs for attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and schizophrenia (SCZ) were computed using lassosum and in a model including all three PRSs and other covariates, and the PRS of ADHD (β = -0.14; 95% confidence interval [CI]: -0.24 to -0.03; p value = 0.010) and MDD (β = -0.16; 95% CI: -0.27 to -0.04; p value = 0.005) predicted worse quantitative lithium response. A higher SCZ PRS was associated with higher rates of medication nonadherence (OR = 1.61; 95% CI: 1.34-1.93; p value = 2e-7). This study indicates that genetic risk for ADHD and depression may influence lithium treatment response. Interestingly, a higher SCZ PRS was associated with poor adherence, which can negatively impact treatment response. Incorporating genetic risk of ADHD, depression, and SCZ in combination with clinical risk may lead to better clinical care for patients with BD.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
700	1	a Millischer, Vincentu Karolinska Institutet4 aut
700	1	a Batzler, Anthony4 aut
700	1	a Larrabee, Beth4 aut
700	1	a Hou, Liping4 aut
700	1	a Papiol, Sergi4 aut
700	1	a Heilbronner, Urs4 aut
700	1	a Adli, Mazda4 aut
700	1	a Akiyama, Kazufumi4 aut
700	1	a Akula, Nirmala4 aut
700	1	a Amare, Azmeraw T4 aut
700	1	a Ardau, Raffaella4 aut
700	1	a Arias, Barbara4 aut
700	1	a Aubry, Jean-Michel4 aut
700	1	a Backlund, Lenau Karolinska Institutet4 aut
700	1	a Bauer, Michael4 aut
700	1	a Baune, Bernhard T4 aut
700	1	a Bellivier, Frank4 aut
700	1	a Benabarre, Antoni4 aut
700	1	a Bengesser, Susanne4 aut
700	1	a Bhattacharjee, Abesh Kumar4 aut
700	1	a Cervantes, Pablo4 aut
700	1	a Chen, Hsi-Chung4 aut
700	1	a Chillotti, Caterinau Karolinska Institutet4 aut
700	1	a Cichon, Sven4 aut
700	1	a Clark, Scott R4 aut
700	1	a Colom, Francesc4 aut
700	1	a Cruceanu, Cristiana4 aut
700	1	a Czerski, Piotr M4 aut
700	1	a Dalkner, Nina4 aut
700	1	a Degenhardt, Franziska4 aut
700	1	a Del Zompo, Maria4 aut
700	1	a DePaulo, J Raymond4 aut
700	1	a Étain, Bruno4 aut
700	1	a Falkai, Peter4 aut
700	1	a Ferensztajn-Rochowiak, Ewa4 aut
700	1	a Forstner, Andreas J4 aut
700	1	a Frisen, Louiseu Karolinska Institutet4 aut
700	1	a Gard, Sébastien4 aut
700	1	a Garnham, Julie S4 aut
700	1	a Goes, Fernando S4 aut
700	1	a Grigoroiu-Serbanescu, Maria4 aut
700	1	a Grof, Paul4 aut
700	1	a Hashimoto, Ryota4 aut
700	1	a Hauser, Joanna4 aut
700	1	a Herms, Stefan4 aut
700	1	a Hoffmann, Per4 aut
700	1	a Jamain, Stephane4 aut
700	1	a Jiménez, Esther4 aut
700	1	a Kahn, Jean-Pierre4 aut
700	1	a Kassem, Layla4 aut
700	1	a Kato, Tadafumi4 aut
700	1	a Kelsoe, John R4 aut
700	1	a Kittel-Schneider, Sarah4 aut
700	1	a König, Barbara4 aut
700	1	a Kuo, Po-Hsiu4 aut
700	1	a Kusumi, Ichiro4 aut
700	1	a Laje, Gonzalo4 aut
700	1	a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt
700	1	a Lavebratt, Catharina4 aut
700	1	a Leboyer, Marion4 aut
700	1	a Leckband, Susan G4 aut
700	1	a Maj, Mariou Karolinska Institutet4 aut
700	1	a Manchia, Mirko4 aut
700	1	a Martinsson, Linau Karolinska Institutet4 aut
700	1	a McCarthy, Michael J4 aut
700	1	a McElroy, Susan L4 aut
700	1	a Mitchell, Philip B4 aut
700	1	a Mitjans, Marina4 aut
700	1	a Mondimore, Francis M4 aut
700	1	a Monteleone, Palmiero4 aut
700	1	a Nievergelt, Caroline M4 aut
700	1	a Nöthen, Markus M4 aut
700	1	a Novák, Tomas4 aut
700	1	a O'Donovan, Claire4 aut
700	1	a Osby, Urban4 aut
700	1	a Ozaki, Norio4 aut
700	1	a Pfennig, Andrea4 aut
700	1	a Pisanu, Claudia4 aut
700	1	a Potash, James B4 aut
700	1	a Reif, Andreas4 aut
700	1	a Reininghaus, Eva4 aut
700	1	a Rietschel, Marcella4 aut
700	1	a Rouleau, Guy A4 aut
700	1	a Rybakowski, Janusz K4 aut
700	1	a Schalling, Martin4 aut
700	1	a Schofield, Peter R4 aut
700	1	a Schubert, Klaus Oliver4 aut
700	1	a Schweizer, Barbara W4 aut
700	1	a Severino, Giovanni4 aut
700	1	a Shekhtman, Tatyana4 aut
700	1	a Shilling, Paul D4 aut
700	1	a Shimoda, Katzutaka4 aut
700	1	a Simhandl, Christian4 aut
700	1	a Slaney, Claire M4 aut
700	1	a Squassina, Alessio4 aut
700	1	a Stamm, Thomas4 aut
700	1	a Stopkova, Pavla4 aut
700	1	a Tortorella, Alfonso4 aut
700	1	a Turecki, Gustavo4 aut
700	1	a Vieta, Eduard4 aut
700	1	a Witt, Stephanie H4 aut
700	1	a Zandi, Peter P4 aut
700	1	a Fullerton, Janice M4 aut
700	1	a Alda, Martin4 aut
700	1	a Frye, Mark A4 aut
700	1	a Schulze, Thomas G4 aut
700	1	a McMahon, Francis J4 aut
700	1	a Biernacka, Joanna M4 aut
710	2	a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
773	0	t Complex psychiatryd : S. Karger AGg 7:3-4, s. 80-89q 7:3-4<80-89x 2673-3005x 2673-298X
856	4 8	u https://gup.ub.gu.se/publication/322804
856	4 8	u https://doi.org/10.1159/000519707
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:236408127

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Av författaren/redakt...: Coombes, Brandon ...; Millischer, Vinc ...; Batzler, Anthony; Larrabee, Beth; Hou, Liping; Papiol, Sergi; visa fler...; Heilbronner, Urs; Adli, Mazda; Akiyama, Kazufum ...; Akula, Nirmala; Amare, Azmeraw T; Ardau, Raffaella; Arias, Barbara; Aubry, Jean-Mich ...; Backlund, Lena; Bauer, Michael; Baune, Bernhard ...; Bellivier, Frank; Benabarre, Anton ...; Bengesser, Susan ...; Bhattacharjee, A ...; Cervantes, Pablo; Chen, Hsi-Chung; Chillotti, Cater ...; Cichon, Sven; Clark, Scott R; Colom, Francesc; Cruceanu, Cristi ...; Czerski, Piotr M; Dalkner, Nina; Degenhardt, Fran ...; Del Zompo, Maria; DePaulo, J Raymo ...; Étain, Bruno; Falkai, Peter; Ferensztajn-Roch ...; Forstner, Andrea ...; Frisen, Louise; Gard, Sébastien; Garnham, Julie S; Goes, Fernando S; Grigoroiu-Serban ...; Grof, Paul; Hashimoto, Ryota; Hauser, Joanna; Herms, Stefan; Hoffmann, Per; Jamain, Stephane; Jiménez, Esther; Kahn, Jean-Pierr ...; Kassem, Layla; Kato, Tadafumi; Kelsoe, John R; Kittel-Schneider ...; König, Barbara; Kuo, Po-Hsiu; Kusumi, Ichiro; Laje, Gonzalo; Landén, Mikael, ...; Lavebratt, Catha ...; Leboyer, Marion; Leckband, Susan ...; Maj, Mario; Manchia, Mirko; Martinsson, Lina; McCarthy, Michae ...; McElroy, Susan L; Mitchell, Philip ...; Mitjans, Marina; Mondimore, Franc ...; Monteleone, Palm ...; Nievergelt, Caro ...; Nöthen, Markus M; Novák, Tomas; O'Donovan, Clair ...; Osby, Urban; Ozaki, Norio; Pfennig, Andrea; Pisanu, Claudia; Potash, James B; Reif, Andreas; Reininghaus, Eva; Rietschel, Marce ...; Rouleau, Guy A; Rybakowski, Janu ...; Schalling, Marti ...; Schofield, Peter ...; Schubert, Klaus ...; Schweizer, Barba ...; Severino, Giovan ...; Shekhtman, Tatya ...; Shilling, Paul D; Shimoda, Katzuta ...; Simhandl, Christ ...; Slaney, Claire M; Squassina, Aless ...; Stamm, Thomas; Stopkova, Pavla; Tortorella, Alfo ...; Turecki, Gustavo; Vieta, Eduard; Witt, Stephanie ...; Zandi, Peter P; Fullerton, Janic ...; Alda, Martin; Frye, Mark A; Schulze, Thomas ...; McMahon, Francis ...; Biernacka, Joann ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

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Av lärosätet: Göteborgs universitet; Karolinska Institutet

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