Sökning: WFRF:(Ekman Anna Karin) > Unimpaired postpran...
Fältnamn | Indikatorer | Metadata |
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000 | 04143naa a2200589 4500 | |
001 | oai:gup.ub.gu.se/177027 | |
003 | SwePub | |
008 | 240528s2013 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/1770272 URI |
024 | 7 | a https://doi.org/10.1002/mds.252462 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Unger, M. M.4 aut |
245 | 1 0 | a Unimpaired postprandial pancreatic polypeptide secretion in Parkinson's disease and REM sleep behavior disorder |
264 | c 2012-12-12 | |
264 | 1 | b Wiley,c 2013 |
520 | a Background: Pancreatic polypeptide is released immediately after food ingestion. The release is operated by vagal-abdominal projections and has therefore been suggested as a test for vagal nerve integrity. Pathoanatomical and clinical studies indicate vagal dysfunction in early Parkinson's disease (PD). Methods: We assessed the postprandial secretion of pancreatic polypeptide and motilin in healthy controls (n = 18) and patients with idiopathic rapid-eye-movement sleep behavior disorder (iRBD, n = 10), a potential premotor stage of PD, as well as in drug-naive (n = 19) and treated (n = 19) PD patients. Results: The postprandial pancreatic polypeptide secretion showed a physiological pattern in all groups and even an enhanced response in drug-naive PD and iRBD. Motilin concentrations correlated with pancreatic polypeptide concentrations. Conclusions: Postprandial pancreatic polypeptide secretion is not a suitable test for vagal nerve integrity in PD. The unimpaired pancreatic polypeptide response in iRBD and PD might be explained by partially intact vagal-abdominal projections or compensatory mechanisms substituting a defective neuronal brain–gut axis. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
653 | a pancreatic polypeptide (PP) | |
653 | a vagal nerve | |
653 | a Parkinson's disease | |
653 | a REM sleep behavior disorder (RBD) | |
653 | a dopaminergic modulation | |
653 | a autonomic neuropathy | |
653 | a brain pathology | |
653 | a rat-brain | |
653 | a erythromycin | |
653 | a somatostatin | |
653 | a denervation | |
653 | a dysfunction | |
653 | a vagotomy | |
653 | a ghrelin | |
700 | 1 | a Ekman, Rolf,d 1938u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xekrol |
700 | 1 | a Björklund, Anna-Karinu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbjoan |
700 | 1 | a Karlsson, Gösta,d 1961u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xkagos |
700 | 1 | a Andersson, Chatarinau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut |
700 | 1 | a Mankel, K.4 aut |
700 | 1 | a Bohne, K.4 aut |
700 | 1 | a Tebbe, J. J.4 aut |
700 | 1 | a Stiasny-Kolster, K.4 aut |
700 | 1 | a Moller, J. C.4 aut |
700 | 1 | a Mayer, G.4 aut |
700 | 1 | a Kann, P. H.4 aut |
700 | 1 | a Oertel, W. H.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Movement Disordersd : Wileyg 28:4, s. 529-533q 28:4<529-533x 0885-3185 |
856 | 4 8 | u https://gup.ub.gu.se/publication/177027 |
856 | 4 8 | u https://doi.org/10.1002/mds.25246 |
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