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Interplay of body m...
Interplay of body mass index and metabolic syndrome : association with physiological age from midlife to late-life
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- Ler, Peggy (författare)
- Karolinska Institutet
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- Ploner, Alexander (författare)
- Karolinska Institutet
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- Finkel, Deborah (författare)
- Jönköping University,HHJ, Institutet för gerontologi,Center for Economic and Social Research, University of Southern California, Los Angeles, CA, United States ; Institute of Gerontology, Jönköping University, Sweden
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- Reynolds, Chandra A. (författare)
- Institute for Behavioral Genetics, University of Colorado Boulder, United States,Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado, USA
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- Zhan, Yiqiang (författare)
- Karolinska Institutet
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- Jylhävä, Juulia (författare)
- Karolinska Institutet
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- Dahl Aslan, Anna K., 1975- (författare)
- Högskolan i Skövde,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Välbefinnande vid långvariga hälsoproblem (WeLHP), Wellbeing in Long-term Health Problems,School of Health Sciences, University of Skövde, Skövde, Sweden
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- Karlsson, Ida K. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Springer Nature, 2024
- 2024
- Engelska.
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Ingår i: GeroScience. - : Springer Nature. - 2509-2715. ; 46:12, s. 2605-2617
- Relaterad länk:
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https://doi.org/10.1...
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https://his.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Obesity and metabolic syndrome (MetS) share common pathophysiological characteristics with aging. To better understand their interplay, we examined how body mass index (BMI) and MetS jointly associate with physiological age, and if the associations changed from midlife to late-life. We used longitudinal data from 1,825 Swedish twins. Physiological age was measured as frailty index (FI) and functional aging index (FAI) and modeled independently in linear mixed-effects models adjusted for chronological age, sex, education, and smoking. We assessed curvilinear associations of BMI and chronological age with physiological age, and interactions between BMI, MetS, and chronological age. We found a significant three-way interaction between BMI, MetS, and chronological age on FI (p-interaction = 0·006), not FAI. Consequently, we stratified FI analyses by age: < 65, 65–85, and ≥ 85 years, and modeled FAI across ages. Except for FI at ages ≥ 85, BMI had U-shaped associations with FI and FAI, where BMI around 26-28 kg/m2 was associated with the lowest physiological age. MetS was associated with higher FI and FAI, except for FI at ages < 65, and modified the BMI-FI association at ages 65–85 (p-interaction = 0·02), whereby the association between higher BMI levels and FI was stronger in individuals with MetS. Age modified the MetS-FI association in ages ≥ 85, such that it was stronger at higher ages (p-interaction = 0·01). Low BMI, high BMI, and metabolic syndrome were associated with higher physiological age, contributing to overall health status among older individuals and potentially accelerating aging.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Nyckelord
- Biological age
- Frailty index
- Metabolic health
- Metabolic syndrome
- Obesity
- Wellbeing in long-term health problems (WeLHP)
- Välbefinnande vid långvariga hälsoproblem (WeLHP)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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