Systemic tocopherols and F2-isoprostanes and the risk of Alzheimer's disease and dementia: a prospective population-based study

Systemic tocopherols and F2-isoprostanes and the risk of Alzheimer's disease and dementia : a prospective population-based study

Helmersson, Johanna (författare): Uppsala universitet,Institutionen för medicinska vetenskaper,Oxidativ stress och inflammation

Sjögren, Per (författare): Uppsala universitet,Oxidativ stress och inflammation

Basu, Samar (författare): Uppsala universitet,Oxidativ stress och inflammation

(creator_code:org_t)

2009
2009
Engelska.
Ingår i: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 18:1, s. 71-78

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.3...; visa färre...

Abstract Ämnesord

Stäng

Oxidative stress in the brain is suggested to be involved in the pathophysiology of Alzheimer's disease (AD). In this study, serum alpha- and gamma-tocopherol, the two major systemic antioxidants, were analyzed at two examinations of the ULSAM-study, a longitudinal, community-based study of elderly men (age 70, n = 616 and age 77, n = 761). In addition, urinary F2-isoprostane levels, as markers of systemic oxidative stress, were analyzed at the age of 77 in this cohort (n = 679). Cox regression analyses were used to examine associations between serum alpha-, gamma-tocopherol and urinary F2-isoprostane levels and AD, any type of dementia (all-cause dementia) and non-AD dementia. On follow-up (median, 12.3 years), 40 subjects developed AD and 86 subjects developed all-cause dementia. Serum alpha- and gamma-tocopherol or urinary F2-isoprostane levels were not associated with the future risk of AD or dementia. In conclusion, systemic serum alpha- and gamma-tocopherol and urinary F2-isoprostane levels are not associated with the future risk of AD or dementia and do not seem to be useful predictors of clinical AD or dementia.

Av författaren/redakt...: Sundelöf, Johan; Kilander, Lena; Helmersson, Joha ...; Larsson, Anders; Rönnemaa, Elina; Degerman-Gunnars ...; visa fler...; Sjögren, Per; Basun, Hans; Lannfelt, Lars; Basu, Samar; visa färre...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.