Contextualising adverse events of special interest to characterise the baseline incidence rates in 24 million patients with COVID-19 across 26 databases: a multinational retrospective cohort study.

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Fältnamn	Indikatorer	Metadata
000		06431naa a2201093 4500
001		oai:gup.ub.gu.se/326076
003		SwePub
008		240910s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/3260762 URI
024	7	a https://doi.org/10.1016/j.eclinm.2023.1019322 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Voss, Erica A4 aut
245	1 0	a Contextualising adverse events of special interest to characterise the baseline incidence rates in 24 million patients with COVID-19 across 26 databases: a multinational retrospective cohort study.
264	1	c 2023
520		a Adverse events of special interest (AESIs) were pre-specified to be monitored for the COVID-19 vaccines. Some AESIs are not only associated with the vaccines, but with COVID-19. Our aim was to characterise the incidence rates of AESIs following SARS-CoV-2 infection in patients and compare these to historical rates in the general population.A multi-national cohort study with data from primary care, electronic health records, and insurance claims mapped to a common data model. This study's evidence was collected between Jan 1, 2017 and the conclusion of each database (which ranged from Jul 2020 to May 2022). The 16 pre-specified prevalent AESIs were: acute myocardial infarction, anaphylaxis, appendicitis, Bell's palsy, deep vein thrombosis, disseminated intravascular coagulation, encephalomyelitis, Guillain- Barré syndrome, haemorrhagic stroke, non-haemorrhagic stroke, immune thrombocytopenia, myocarditis/pericarditis, narcolepsy, pulmonary embolism, transverse myelitis, and thrombosis with thrombocytopenia. Age-sex standardised incidence rate ratios (SIR) were estimated to compare post-COVID-19 to pre-pandemic rates in each of the databases.Substantial heterogeneity by age was seen for AESI rates, with some clearly increasing with age but others following the opposite trend. Similarly, differences were also observed across databases for same health outcome and age-sex strata. All studied AESIs appeared consistently more common in the post-COVID-19 compared to the historical cohorts, with related meta-analytic SIRs ranging from 1.32 (1.05 to 1.66) for narcolepsy to 11.70 (10.10 to 13.70) for pulmonary embolism.Our findings suggest all AESIs are more common after COVID-19 than in the general population. Thromboembolic events were particularly common, and over 10-fold more so. More research is needed to contextualise post-COVID-19 complications in the longer term.None.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
700	1	a Shoaibi, Azza4 aut
700	1	a Yin Hui Lai, Lana4 aut
700	1	a Blacketer, Clair4 aut
700	1	a Alshammari, Thamir4 aut
700	1	a Makadia, Rupa4 aut
700	1	a Haynes, Kevin4 aut
700	1	a Sena, Anthony G4 aut
700	1	a Rao, Gowtham4 aut
700	1	a van Sandijk, Sebastiaan4 aut
700	1	a Fraboulet, Clement4 aut
700	1	a Boyer, Laurent4 aut
700	1	a Le Carrour, Tanguy4 aut
700	1	a Horban, Scott4 aut
700	1	a Morales, Daniel R4 aut
700	1	a Martínez Roldán, Jordi4 aut
700	1	a Ramírez-Anguita, Juan Manuel4 aut
700	1	a Mayer, Miguel A4 aut
700	1	a de Wilde, Marcel4 aut
700	1	a John, Luis H4 aut
700	1	a Duarte-Salles, Talita4 aut
700	1	a Roel, Elena4 aut
700	1	a Pistillo, Andrea4 aut
700	1	a Kolde, Raivo4 aut
700	1	a Maljković, Filip4 aut
700	1	a Denaxas, Spiros4 aut
700	1	a Papez, Vaclav4 aut
700	1	a Kahn, Michael G4 aut
700	1	a Natarajan, Karthik4 aut
700	1	a Reich, Christian4 aut
700	1	a Secora, Alex4 aut
700	1	a Minty, Evan P4 aut
700	1	a Shah, Nigam H4 aut
700	1	a Posada, Jose D4 aut
700	1	a Garcia Morales, Maria Teresa4 aut
700	1	a Bosca, Diego4 aut
700	1	a Cadenas Juanino, Honorio4 aut
700	1	a Diaz Holgado, Antonio4 aut
700	1	a Pedrera Jiménez, Miguel4 aut
700	1	a Serrano Balazote, Pablo4 aut
700	1	a García Barrio, Noelia4 aut
700	1	a Şen, Selçuk4 aut
700	1	a Üresin, Ali Yağız4 aut
700	1	a Erdogan, Baris4 aut
700	1	a Belmans, Luc4 aut
700	1	a Byttebier, Geert4 aut
700	1	a Malbrain, Manu L N G4 aut
700	1	a Dedman, Daniel J4 aut
700	1	a Cuccu, Zara4 aut
700	1	a Vashisht, Rohit4 aut
700	1	a Butte, Atul J4 aut
700	1	a Patel, Ayan4 aut
700	1	a Dahm, Lisa4 aut
700	1	a Han, Cora4 aut
700	1	a Bu, Fan4 aut
700	1	a Arshad, Faaizah4 aut
700	1	a Ostropolets, Anna4 aut
700	1	a Nyberg, Fredrik,d 1961u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine4 aut0 (Swepub:gu)xnybef
700	1	a Hripcsak, George4 aut
700	1	a Suchard, Marc A4 aut
700	1	a Prieto-Alhambra, Dani4 aut
700	1	a Rijnbeek, Peter R4 aut
700	1	a Schuemie, Martijn J4 aut
700	1	a Ryan, Patrick B4 aut
710	2	a Göteborgs universitetb Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa4 org
773	0	t EClinicalMedicineg 58q 58x 2589-5370
856	4 8	u https://gup.ub.gu.se/publication/326076
856	4 8	u https://doi.org/10.1016/j.eclinm.2023.101932

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Av författaren/redakt...: Voss, Erica A; Shoaibi, Azza; Yin Hui Lai, Lan ...; Blacketer, Clair; Alshammari, Tham ...; Makadia, Rupa; visa fler...; Haynes, Kevin; Sena, Anthony G; Rao, Gowtham; van Sandijk, Seb ...; Fraboulet, Cleme ...; Boyer, Laurent; Le Carrour, Tang ...; Horban, Scott; Morales, Daniel ...; Martínez Roldán, ...; Ramírez-Anguita, ...; Mayer, Miguel A; de Wilde, Marcel; John, Luis H; Duarte-Salles, T ...; Roel, Elena; Pistillo, Andrea; Kolde, Raivo; Maljković, Filip; Denaxas, Spiros; Papez, Vaclav; Kahn, Michael G; Natarajan, Karth ...; Reich, Christian; Secora, Alex; Minty, Evan P; Shah, Nigam H; Posada, Jose D; Garcia Morales, ...; Bosca, Diego; Cadenas Juanino, ...; Diaz Holgado, An ...; Pedrera Jiménez, ...; Serrano Balazote ...; García Barrio, N ...; Şen, Selçuk; Üresin, Ali Yağı ...; Erdogan, Baris; Belmans, Luc; Byttebier, Geert; Malbrain, Manu L ...; Dedman, Daniel J; Cuccu, Zara; Vashisht, Rohit; Butte, Atul J; Patel, Ayan; Dahm, Lisa; Han, Cora; Bu, Fan; Arshad, Faaizah; Ostropolets, Ann ...; Nyberg, Fredrik, ...; Hripcsak, George; Suchard, Marc A; Prieto-Alhambra, ...; Rijnbeek, Peter ...; Schuemie, Martij ...; Ryan, Patrick B; visa färre...

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