Sökning: WFRF:(Mahaffey Kenneth W.) >
Trade-off of myocar...
Trade-off of myocardial infarction vs. bleeding types on mortality after acute coronary syndrome : lessons from the Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) randomized trial
-
- Valgimigli, Marco (författare)
- Univ Hosp Bern, Swiss Cardiovasc Ctr Bern, CH-3010 Bern, Switzerland.;Erasmus MC, Thoraxctr, Rotterdam, Netherlands.
-
- Costa, Francesco (författare)
- Erasmus MC, Thoraxctr, Rotterdam, Netherlands.;Univ Messina, Dept Clin & Expt Med, Policlin G Martino, Messina, Italy.
-
- Lokhnygina, Yuliya (författare)
- Duke Clin Res Inst, Durham, NC USA.
-
visa fler...
-
- Clare, Robert M. (författare)
- Duke Clin Res Inst, Durham, NC USA.
-
- Wallentin, Lars (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
-
- Moliterno, David J. (författare)
- Univ Kentucky, Div Cardiovasc Med, Gill Heart Inst, Lexington, KY USA.
-
- Armstrong, Paul W. (författare)
- Univ Alberta, Div Cardiol, Edmonton, AB, Canada.
-
- White, Harvey D. (författare)
- Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand.
-
- Held, Claes (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
-
- Aylward, Philip E. (författare)
- Flinders Univ S Australia, South Australian Hlth & Med Res Inst, Adelaide, SA, Australia.;Med Ctr, Adelaide, SA, Australia.
-
- Van de Werf, Frans (författare)
- Univ Leuven, Dept Cardiol, Leuven, Belgium.
-
- Harrington, Robert A. (författare)
- Stanford Univ, Dept Med, Stanford, CA 94305 USA.
-
- Mahaffey, Kenneth W. (författare)
- Stanford Univ, Dept Med, Stanford, CA 94305 USA.
-
- Tricoci, Pierluigi (författare)
- Duke Clin Res Inst, Durham, NC USA.
-
visa färre...
-
Univ Hosp Bern, Swiss Cardiovasc Ctr Bern, CH-3010 Bern, Switzerland;Erasmus MC, Thoraxctr, Rotterdam, Netherlands. Erasmus MC, Thoraxctr, Rotterdam, Netherlands.;Univ Messina, Dept Clin & Expt Med, Policlin G Martino, Messina, Italy. (creator_code:org_t)
- 2016-11-13
- 2017
- Engelska.
-
Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 38:11, s. 804-810
- Relaterad länk:
-
https://academic.oup...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Aims: Dual antiplatelet therapy reduces non-fatal ischaemic events after acute coronary syndrome (ACS) but increases bleeding to a similar extent. We sought to determine the prognostic impact of myocardial infarction (MI) vs. bleeding during an extended follow-up period to gain insight into the trade-off between efficacy and safety among patients after ACS.Methods and results: In 12 944 patients with non-ST-segment elevation ACS from the Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRACER) trial, we investigated the relative impact of MI and bleeding occurring> 30 days post-ACS and subsequent all-cause mortality. Bleeding was graded according to Bleeding Academic Research Consortium (BARC) criteria. MI was associated with a five-fold increase in mortality. BARC type 2 and 3, but not type 1, bleeding had a significant impact on mortality. MI was associated with a greater risk of mortality compared with BARC 2 [relative risk (RR) 3.5; 95% confidence interval (CI) 2.08-4.77; P< 0.001] and BARC 3a bleeding (RR 2.23; 95% CI 1.36-3.64; P = 0.001), and a risk similar to BARC 3b bleeding (RR 1.37; 95% CI 0.81-2.30; P = 0.242). Risk of death after MI was significantly lower than after BARC 3c bleeding (RR 0.22; 95% CI 0.13-0.36; P< 0.001). MI and bleeding had similar time-associations with mortality, which remained significant for several months, still being higher early after the event.Conclusion: In patients treated with antiplatelet therapy after ACS, both MI and bleeding significantly impacted mortality with similar time-dependency. Although BARC 2 and 3a bleeding were less prognostic for death than MI, the risk of mortality was equivalent between BARC 3b bleeding and MI, and was higher following BARC 3c bleeding.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Bleeding
- Myocardial infarction
- DAPT
- Acute coronary syndrome
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Valgimigli, Marc ...
-
Costa, Francesco
-
Lokhnygina, Yuli ...
-
Clare, Robert M.
-
Wallentin, Lars
-
Moliterno, David ...
-
visa fler...
-
Armstrong, Paul ...
-
White, Harvey D.
-
Held, Claes
-
Aylward, Philip ...
-
Van de Werf, Fra ...
-
Harrington, Robe ...
-
Mahaffey, Kennet ...
-
Tricoci, Pierlui ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
European Heart J ...
- Av lärosätet
-
Uppsala universitet