WFRF:(Palmqvist Lars 1965)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04714naa a2201057 4500 | |
| 001 | oai:gup.ub.gu.se/146777 | |
| 003 | SwePub | |
| 008 | 240528s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/1467772 URI |
| 024 | 7 | a https://doi.org/10.1016/j.ccr.2011.06.0202 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Heuser, Michael4 aut |
| 245 | 1 0 | a Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex. |
| 264 | 1 | b Elsevier BV,c 2011 |
| 520 | a Pathways defining susceptibility of normal cells to oncogenic transformation may be valuable therapeutic targets. We characterized the cell of origin and its critical pathways in MN1-induced leukemias. Common myeloid (CMP) but not granulocyte-macrophage progenitors (GMP) could be transformed by MN1. Complementation studies of CMP-signature genes in GMPs demonstrated that MN1-leukemogenicity required the MEIS1/AbdB-like HOX-protein complex. ChIP-sequencing identified common target genes of MN1 and MEIS1 and demonstrated identical binding sites for a large proportion of their chromatin targets. Transcriptional repression of MEIS1 targets in established MN1 leukemias demonstrated antileukemic activity. As MN1 relies on but cannot activate expression of MEIS1/AbdB-like HOX proteins, transcriptional activity of these genes determines cellular susceptibility to MN1-induced transformation and may represent a promising therapeutic target. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
| 653 | a Animals | |
| 653 | a Cell Transformation | |
| 653 | a Neoplastic | |
| 653 | a metabolism | |
| 653 | a pathology | |
| 653 | a Gene Expression Profiling | |
| 653 | a Gene Expression Regulation | |
| 653 | a Leukemic | |
| 653 | a Genes | |
| 653 | a Dominant | |
| 653 | a genetics | |
| 653 | a Granulocyte-Macrophage Progenitor Cells | |
| 653 | a metabolism | |
| 653 | a pathology | |
| 653 | a Homeodomain Proteins | |
| 653 | a metabolism | |
| 653 | a Humans | |
| 653 | a Leukemia | |
| 653 | a Myeloid | |
| 653 | a Acute | |
| 653 | a genetics | |
| 653 | a pathology | |
| 653 | a Mice | |
| 653 | a Mice | |
| 653 | a Inbred C57BL | |
| 653 | a Models | |
| 653 | a Biological | |
| 653 | a Multiprotein Complexes | |
| 653 | a metabolism | |
| 653 | a Neoplasm Proteins | |
| 653 | a metabolism | |
| 653 | a Promoter Regions | |
| 653 | a Genetic | |
| 653 | a genetics | |
| 653 | a Protein Binding | |
| 653 | a Tumor Suppressor Proteins | |
| 653 | a metabolism | |
| 700 | 1 | a Yun, Haiyang4 aut |
| 700 | 1 | a Berg, Tobias4 aut |
| 700 | 1 | a Yung, Eric4 aut |
| 700 | 1 | a Argiropoulos, Bob4 aut |
| 700 | 1 | a Kuchenbauer, Florian4 aut |
| 700 | 1 | a Park, Gyeongsin4 aut |
| 700 | 1 | a Hamwi, Iyas4 aut |
| 700 | 1 | a Palmqvist, Lars,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine4 aut0 (Swepub:gu)xpalla |
| 700 | 1 | a Lai, Courteney K4 aut |
| 700 | 1 | a Leung, Malina4 aut |
| 700 | 1 | a Lin, Grace4 aut |
| 700 | 1 | a Chaturvedi, Anuhar4 aut |
| 700 | 1 | a Thakur, Basant Kumar4 aut |
| 700 | 1 | a Iwasaki, Masayuki4 aut |
| 700 | 1 | a Bilenky, Mikhail4 aut |
| 700 | 1 | a Thiessen, Nina4 aut |
| 700 | 1 | a Robertson, Gordon4 aut |
| 700 | 1 | a Hirst, Martin4 aut |
| 700 | 1 | a Kent, David4 aut |
| 700 | 1 | a Wilson, Nicola K4 aut |
| 700 | 1 | a Göttgens, Bertie4 aut |
| 700 | 1 | a Eaves, Connie4 aut |
| 700 | 1 | a Cleary, Michael L4 aut |
| 700 | 1 | a Marra, Marco4 aut |
| 700 | 1 | a Ganser, Arnold4 aut |
| 700 | 1 | a Humphries, R Keith4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin4 org |
| 773 | 0 | t Cancer celld : Elsevier BVg 20:1, s. 39-52q 20:1<39-52x 1878-3686x 1535-6108 |
| 856 | 4 | u http://www.cell.com/article/S1535610811002327/pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/146777 |
| 856 | 4 8 | u https://doi.org/10.1016/j.ccr.2011.06.020 |
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