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Characterization of the human helicotrema : implications for cochlear duct length and frequency mapping
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- Helpard, Luke (author)
- Western Univ, Sch Biomed Engn, London, ON, Canada
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- Li, Hao, 1984- (author)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Rask-Andersen, Helge (author)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- (creator_code:org_t)
- 2020-01-06
- 2020
- English.
- In: Journal of Otolaryngology - Head & Neck Surgery. - : BMC. - 1916-0216. ; 49
- Journal article (peer-reviewed)
Abstract
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- Background: Despite significant anatomical variation amongst patients, cochlear implant frequency-mapping has traditionally followed a patient-independent approach. Basilar membrane (BM) length is required for patient-specific frequency-mapping, however cochlear duct length (CDL) measurements generally extend to the apical tip of the entire cochlea or have no clearly defined end-point. By characterizing the length between the end of the BM and the apical tip of the entire cochlea (helicotrema length), current CDL models can be corrected to obtain the appropriate BM length. Synchrotron radiation phase-contrast imaging has made this analysis possible due to the soft-tissue contrast through the entire cochlear apex.Methods: Helicotrema linear length and helicotrema angular length measurements were performed on synchrotron radiation phase-contrast imaging data of 14 cadaveric human cochleae. On a sub-set of six samples, the CDL to the apical tip of the entire cochlea (CDLTIP) and the BM length (CDLBM) were determined. Regression analysis was performed to assess the relationship between CDLTIP and CDLBM.Results: The mean helicotrema linear length and helicotrema angular length values were 1.6 +/- 0.9 mm and 67.8 +/- 37.9 degrees, respectively. Regression analysis revealed the following relationship between CDLTIP and CDLBM: CDLBM = 0.88(CDLTIP) + 3.71 (R-2 = 0.995).Conclusion: This is the first known study to characterize the length of the helicotrema in the context of CDL measurements. It was determined that the distance between the end of the BM and the tip of the entire cochlea is clinically consequential. A relationship was determined that can predict the BM length of an individual patient based on their respective CDL measured to the apical tip of the cochlea.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
Keyword
- Helicotrema
- Helicotrema size
- Cochlear duct length
- Basilar membrane
- Cochlear apex
- Cochlear implant
- Frequency mapping
- Synchrotron radiation
Publication and Content Type
- ref (subject category)
- art (subject category)
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