Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance

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Fältnamn	Indikatorer	Metadata
000		02891naa a2200385 4500
001		oai:prod.swepub.kib.ki.se:133463449
003		SwePub
008		240811s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1334634492 URI
024	7	a https://doi.org/10.1155/2016/30853902 DOI
040		a (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Corona-Meraz, FI4 aut
245	1 0	a Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance
264	1	b Hindawi Limited,c 2016
520		a Background. In obesity there is a subclinical chronic low-grade inflammatory response where insulin resistance (IR) may develop. Chemerin is secreted in white adipose tissue and promotes low-grade inflammatory process, where it expressedCMKLR1receptor. The role of chemerin andCMKLR1in inflammatory process secondary to obesity is not defined yet.Methods. Cross-sectional study with 134 individuals classified as with and without obesity by body mass index (BMI) and IR. Body fat storage measurements and metabolic and inflammatory markers were measured by routine methods. Soluble chemerin and basal levels of insulin by ELISA and relative expression ofCMKLR1were evaluated with qPCR and2-ΔΔCTmethod.Results. Differences (P<0.05) were observed between obesity and lean individuals in body fat storage measurements and metabolic-inflammatory markers. BothCMKLR1expression and chemerin levels were increased in obesity without IR. Soluble chemerin levels correlate with adiposity and metabolic markers (r=8.8% to 38.5%),P<0.05.Conclusion. The increment ofCMKLR1expression was associated with insulin production. Increased serum levels of chemerin in obesity were observed, favoring a dysmetabolic response. The results observed in this study suggest that both chemerin andCMKLR1have opposite expression in the context of low-grade inflammatory response manifested in the development of IR.
700	1	a Navarro-Hernandez, RE4 aut
700	1	a Ruiz-Quezada, SL4 aut
700	1	a Madrigal-Ruiz, PM4 aut
700	1	a Castro-Albarran, J4 aut
700	1	a Chavarria-Avila, E4 aut
700	1	a Guzman-Ornelas, MO4 aut
700	1	a Gomez-Banuelos, E4 aut
700	1	a Petri, MH4 aut
700	1	a Ramirez-Cedano, JI4 aut
700	1	a Aguilar-Aldrete, ME4 aut
700	1	a Rios-Ibarra, C4 aut
700	1	a Vazquez-Del Mercado, M4 aut
773	0	t Mediators of inflammationd : Hindawi Limitedg 2016, s. 3085390-q 2016<3085390-x 1466-1861x 0962-9351
856	4	u http://downloads.hindawi.com/journals/mi/2016/3085390.pdf
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:133463449
856	4 8	u https://doi.org/10.1155/2016/3085390

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Av författaren/redakt...: Corona-Meraz, FI; Navarro-Hernande ...; Ruiz-Quezada, SL; Madrigal-Ruiz, P ...; Castro-Albarran, ...; Chavarria-Avila, ...; visa fler...; Guzman-Ornelas, ...; Gomez-Banuelos, ...; Petri, MH; Ramirez-Cedano, ...; Aguilar-Aldrete, ...; Rios-Ibarra, C; Vazquez-Del Merc ...; visa färre...

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