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Plasma metallothionein antibody and cadmium-induced renal dysfunction in an occupational population in China.
- Chen, Liang (författare)
- Jin, Taiyi (författare)
- Huang, Bo (författare)
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- Chang, Xiuli (författare)
- Lei, Lijian (författare)
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- (creator_code:org_t)
- 2005-12-01
- 2006
- Engelska.
- Ingår i: Toxicological sciences : an official journal of the Society of Toxicology. - : Oxford University Press (OUP). - 1096-6080. ; 91:1, s. 104-12
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- It has been reported that anti-metallothionein (a metallothionein antibody) is present in the circulation of healthy subjects and in patients suffering from atopic dermatitis. The aim of this study was to investigate whether cadmium-induced renal dysfunction is related to the presence of the plasma metallothionein antibody (MT-Ab) in workers exposed to cadmium (Cd) occupationally. Plasma metallothionein antibody was determined by enzyme linked immunosorbent assay (ELISA) techniques, and both exposure assessment and risk assessment were conducted in cadmium-exposed workers in China. We demonstrate that there is a significantly increased prevalence of renal dysfunction with respect to the level of urinary cadmium in a dose-dependent manner. We found no significant correlations between the levels of MT-Ab and the external or internal exposure doses of cadmium (p > 0.05), but the levels of MT-Ab did correlate positively with two biomarkers of renal dysfunction-urinary beta2-microglobulin (UB2M; r = 0.218, p < 0.05) and N-acetyl-beta-D-glucosaminidase (UNAG; r = 0.302, p < 0.001)-in the cadmium-exposed workers. Workers who have high levels of MT-Ab display cadmium-induced tubular nephrotoxicity more frequently than those possessing low levels of MT-Ab; odds ratio (OR) 4.2; 95% confidence intervals 1.2-14.5 (p < 0.05). This study suggests that subjects that have higher MT-Ab levels more readily develop cadmium-induced renal dysfunction. Thus, the levels of plasma MT-Ab can be used as a biomarker of susceptibility to renal dysfunction in occupational cadmium exposure.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Adult
- Autoantibodies
- blood
- Cadmium
- toxicity
- Humans
- Kidney
- drug effects
- immunology
- physiopathology
- Kidney Function Tests
- Metallothionein
- blood
- immunology
- Middle Aged
- Occupational Exposure
- Adult
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Toxicological sciences : an official journal of the Society of Toxicology (Sök värdpublikationen i LIBRIS)
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- Chen, Liang
- Jin, Taiyi
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- Chang, Xiuli
- Lei, Lijian
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- Nordberg, Monica
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