Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study

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Fältnamn	Indikatorer	Metadata
000		21413naa a2201561 4500
001		oai:DiVA.org:uu-329628
003		SwePub
008		170926s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:090d445f-f2d3-40b8-b9c9-abe964a82c78
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3296282 URI
024	7	a https://doi.org/10.1016/S2213-8587(17)30096-72 DOI
024	7	a https://lup.lub.lu.se/record/090d445f-f2d3-40b8-b9c9-abe964a82c782 URI
040		a (SwePub)uud (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Zewinger, Stephenu Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany.,Saarland University4 aut
245	1 0	a Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease :b a molecular and genetic association study
264	1	b ELSEVIER SCIENCE INC,c 2017
338		a print2 rdacarrier
520		a Background: Lipoprotein(a) concentrations in plasma are associated with cardiovascular risk in the general population. Whether lipoprotein(a) concentrations or LPA genetic variants predict long-term mortality in patients with established coronary heart disease remains less clear.Methods: We obtained data from 3313 patients with established coronary heart disease in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. We tested associations of tertiles of lipoprotein(a) concentration in plasma and two LPA single-nucleotide polymorphisms ([SNPs] rs10455872 and rs3798220) with all-cause mortality and cardiovascular mortality by Cox regression analysis and with severity of disease by generalised linear modelling, with and without adjustment for age, sex, diabetes diagnosis, systolic blood pressure, BMI, smoking status, estimated glomerular filtration rate, LDL-cholesterol concentration, and use of lipid-lowering therapy. Results for plasma lipoprotein(a) concentrations were validated in five independent studies involving 10 195 patients with established coronary heart disease. Results for genetic associations were replicated through large-scale collaborative analysis in the GENIUS-CHD consortium, comprising 106 353 patients with established coronary heart disease and 19 332 deaths in 22 studies or cohorts.Findings: The median follow-up was 9.9 years. Increased severity of coronary heart disease was associated with lipoprotein(a) concentrations in plasma in the highest tertile (adjusted hazard radio [HR] 1.44, 95% CI 1.14-1.83) and the presence of either LPA SNP (1.88, 1.40-2.53). No associations were found in LURIC with all-cause mortality (highest tertile of lipoprotein(a) concentration in plasma 0.95, 0.81-1.11 and either LPA SNP 1.10, 0.92-1.31) or cardiovascular mortality (0.99, 0.81-1.2 and 1.13, 0.90-1.40, respectively) or in the validation studies.Interpretation: In patients with prevalent coronary heart disease, lipoprotein(a) concentrations and genetic variants showed no associations with mortality. We conclude that these variables are not useful risk factors to measure to predict progression to death after coronary heart disease is established.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
700	1	a Kleber, Marcus E.u Friedrich Schiller Univ, Inst Nutr, Jena, Germany.,Friedrich Schiller University Jena4 aut
700	1	a Tragante, Viniciusu University Medical Center Utrecht4 aut
700	1	a McCubrey, Raymond O.u Univ Utah Sch Med, Intermountain Heart Inst, Intermountain Med Ctr, Salt Lake City, UT USA.,University of Utah,University of Verona4 aut
700	1	a Schmidt, Amand F.u University College London4 aut
700	1	a Direk, Kenanu University College London4 aut
700	1	a Laufs, Ulrichu Saarland Univ Hosp, Dept Internal Med 3, Homburg, Germany.,Saarland University4 aut
700	1	a Werner, Christianu Saarland Univ Hosp, Dept Internal Med 3, Homburg, Germany.,Saarland University4 aut
700	1	a Koenig, Wolfgangu Univ Ulm Med Ctr, Dept Internal Med Cardiol 2, Ulm, Germany.;Tech Univ Munich, Deutsch Herzzentrum M nchen, Munich, Germany.;Partner site Munich Heart Alliance, German Ctr Cardiovasc Res DZHK, Munich, Germany.,German Centre for Cardiovascular Research4 aut
700	1	a Rothenbacher, Dietrichu German Canc Ctr DKFZ, Div Clin Epidemiol & Ageing Res, Heidelberg, Germany.;Univ Ulm, Inst Epidemiol & Med Biometry, Ulm, Germany.;German Ctr Cardiovasc Res DZHK eV, Kiel, Germany.,University of Ulm4 aut
700	1	a Mons, Uteu German Canc Ctr DKFZ, Div Clin Epidemiol & Ageing Res, Heidelberg, Germany.,German Cancer Research Centre4 aut
700	1	a Breitling, Lutz P.u German Canc Ctr DKFZ, Div Clin Epidemiol & Ageing Res, Heidelberg, Germany.;Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Hamburg, Germany.,German Cancer Research Centre4 aut
700	1	a Brenner, Herrmannu Heidelberg Univ, Dept Med, Network Ageing Res, Mannheim, Germany.;German Canc Ctr DKFZ, Div Clin Epidemiol & Ageing Res, Heidelberg, Germany.,German Cancer Research Centre4 aut
700	1	a Jennings, Richard T.u Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany.;Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Hamburg, Germany.,Saarland University4 aut
700	1	a Petrakis, Ioannisu Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany.,Saarland University4 aut
700	1	a Triem, Sarahu Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany.,Saarland University4 aut
700	1	a Klug, Mirau Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany.,Saarland University4 aut
700	1	a Filips, Alexandrau Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany.;UCL, Inst Cardiovasc Sci Facultyof Populat Hlth Sc, London, England.,Saarland University,University of Ottawa4 aut
700	1	a Blankenberg, Stefanu German Centre for Cardiovascular Research4 aut
700	1	a Waldeyer, Christophu German Centre for Cardiovascular Research4 aut
700	1	a Sinning, Christophu German Centre for Cardiovascular Research4 aut
700	1	a Schnabel, Renate B.u German Centre for Cardiovascular Research4 aut
700	1	a Lackner, Karl J.u Univ Med Ctr Mainz, Inst Clin Chem & Lab Med, Mainz, Germany.,Universitätsmedizin Mainz4 aut
700	1	a Vlachopoulou, Efthymiau Univ Helsinki, Haartman Inst, Transplantat Lab, Helsinki, Finland.,University of Helsinki Haartman Institute4 aut
700	1	a Nygard, Ottaru Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Heart Dis, Bergen, Norway.,Haukeland University Hospital4 aut
700	1	a Svingen, Gard Frodahl Tveitevagu Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Heart Dis, Bergen, Norway.,Haukeland University Hospital4 aut
700	1	a Pedersen, Eva Ringdalu Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Heart Dis, Bergen, Norway.,University of Bergen4 aut
700	1	a Tell, Grethe S.u Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland.,University of Bergen4 aut
700	1	a Sinisalo, Juhau Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria.,Helsinki University Central Hospital4 aut
700	1	a Nieminen, Markku S.u Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore.,Helsinki University Central Hospital,University Hospital Leipzig,Jagiellonian University4 aut
700	1	a Laaksonen, Reijou Tampere Univ, Sch Med, Tampere, Finland.;Tampere Univ Hosp, Finnish Clin Biobank Tampere, Tampere, Finland.,Tampere University Hospital4 aut
700	1	a Trompet, Stellau German Ctr Cardiovasc Res DZHK eV, Kiel, Germany.;Leiden Univ Med Ctr, Dept Geriat & Gerontol, Leiden, Netherlands.;Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.,Leiden University Medical Centre4 aut
700	1	a Smit, Roelof A. J.u Uppsala University4 aut
700	1	a Sattar, Naveedu Heidelberg Univ, Dept Med, Mannheim, Germany.;Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland.,University of Glasgow4 aut
700	1	a Jukema, J. Wouteru Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.;Inst Netherlands, Interunivers Cardiol, Utrecht, Netherlands.,Interuniversity Cardiology Institute of the Netherlands4 aut
700	1	a Groesdonk, Heinrich V.u Saarland Univ Hosp, Dept Anesthesiol Intens Care Med & Pain Med, Homburg, Germany.;German Ctr Cardiovasc Res DZHK eV, Kiel, Germany.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.;Univ Otago, Christchurch Heart Inst, Christchurch, New Zealand.,Saarland University4 aut
700	1	a Delgado, Gracielau Univ Utah Sch Med, Intermountain Heart Inst, Intermountain Med Ctr, Salt Lake City, UT USA.;Univ Glasgow, Inst Cardiovascular & Med Sci, Cardiovascular Res Ctr, BHF Glasgow, Glasgow, Lanark, Scotland.;Inst Netherlands, Interunivers Cardiol, Utrecht, Netherlands.,Heidelberg University4 aut
700	1	a Stojakovic, Tatjanau Heidelberg Univ, Dept Med, Mannheim, Germany.;Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.;Univ Glasgow, Inst Cardiovascular & Med Sci, Cardiovascular Res Ctr, BHF Glasgow, Glasgow, Lanark, Scotland.,Medical University of Graz4 aut
700	1	a Pilbrow, Anna P.u Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.,University of Otago4 aut
700	1	a Cameron, Vicky A.u Heart & Lungs Div, Dept Cardiol, Utrecht, Netherlands.;Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland.;Univ Glasgow, Inst Cardiovascular & Med Sci, Cardiovascular Res Ctr, BHF Glasgow, Glasgow, Lanark, Scotland.;Univ Otago, Christchurch Heart Inst, Christchurch, New Zealand.,University of Otago4 aut
700	1	a Richards, A. Marku Univ Otago, Christchurch Heart Inst, Christchurch, New Zealand.;Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore.,National University of Singapore4 aut
700	1	a Doughty, Robert N.u Univ Glasgow, Inst Cardiovascular & Med Sci, Cardiovascular Res Ctr, BHF Glasgow, Glasgow, Lanark, Scotland.;Univ Auckland, Hlth Res Grp, Auckland, New Zealand.,University of Auckland4 aut
700	1	a Gong, Yanu Heart & Lungs Div, Dept Cardiol, Utrecht, Netherlands.;Univ Utah Sch Med, Intermountain Heart Inst, Intermountain Med Ctr, Salt Lake City, UT USA.;Univ Glasgow, Inst Cardiovascular & Med Sci, Cardiovascular Res Ctr, BHF Glasgow, Glasgow, Lanark, Scotland.,Florida Museum Natural History4 aut
700	1	a Cooper-DeHoff, Rhondau Florida Museum Natural History4 aut
700	1	a Johnson, Julieu German Ctr Cardiovasc Res DZHK eV, Kiel, Germany.;Univ Otago, Christchurch Heart Inst, Christchurch, New Zealand.,Glenfield Hospital4 aut
700	1	a Scholz, Markusu Univ Utah Sch Med, Intermountain Heart Inst, Intermountain Med Ctr, Salt Lake City, UT USA.;Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore.;Univ Leipzig, D-RES CTR C Leipzig, Germany.4 aut
700	1	a Beutner, Franku Univ Leipzig, Leipzig, Germany.,University of Leipzig Heart Center4 aut
700	1	a Thiery, Joachimu Univ Hosp, Leipzig, Germany.,University Hospital Leipzig4 aut
700	1	a Smith, Gustavu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiovascular Epigenetics,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-gvs
700	1	a Vilmundarson, Ragnar O.u Univ Ottawa Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.,University of Ottawa4 aut
700	1	a McPherson, Ruthu Univ Ottawa Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.,University of Ottawa4 aut
700	1	a Stewart, Alexandre F. R.u Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore.;Univ Florida, Dept Pharmacotherapy, Colleges Pharm, Gainesville, FL USA.;Univ Florida, Dept Pharmacotherapy, Translat Res & Ctr Pharmac, Gainesville, FL USA.;Univ Ottawa Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.;Washington Univ, Sch Med, St Louis, MO USA.4 aut
700	1	a Cresci, Sharonu Univ Ottawa Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.;Washington Univ, Sch Med, Dept Med, St Louis, MO USA.;Washington Univ, Sch Med, Dept Genet, St Louis, MO USA.,Washington University in St. Louis4 aut
700	1	a Lenzini, Petra A.u Inst Med Informat, Stat & Epidemiol, Leipzig, Germany.;Univ Ottawa Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.;Washington Univ, Sch Med, Stat Genom Div, Dept Genet, St Louis, MO USA.,Washington University in St. Louis4 aut
700	1	a Spertus, John A.u Inst Med Informat, Stat & Epidemiol, Leipzig, Germany.;St Lukes Mid Amer Heart Inst, Kansas City, MO USA.;Univ Missouri, Dept Biomed Hlth Informat, Kansas City, MO USA.,University of Missouri-Kansas City4 aut
700	1	a Olivieri, Olivierou Heart & Lungs Div, Dept Cardiol, Utrecht, Netherlands.;Univ Verona, Dept Med, Verona, Italy.4 aut
700	1	a Girelli, Domenicou Univ Florida, Dept Pharmacotherapy, Colleges Pharm, Gainesville, FL USA.;Univ Florida, Dept Pharmacotherapy, Translat Res & Ctr Pharmac, Gainesville, FL USA.;Univ Verona, Dept Med, Verona, Italy.,University of Verona4 aut
700	1	a Martinelli, Nicola I.u Univ Verona, Dept Med, Verona, Italy.,University of Verona4 aut
700	1	a Leiherer, Andreasu Univ Florida, Dept Pharmacotherapy, Colleges Pharm, Gainesville, FL USA.;Univ Florida, Dept Pharmacotherapy, Translat Res & Ctr Pharmac, Gainesville, FL USA.;Inst Med Informat, Stat & Epidemiol, Leipzig, Germany.;Vorarlberg Inst Vasc Invest & Treatment, Feldkirch, Austria.;Principal Liechtenstein, Private Univ, Triesen, Liechtenstein.,Private University of the Principality of Liechtenstein4 aut
700	1	a Saely, Christoph H.u Vorarlberg Inst Vasc Invest & Treatment, Feldkirch, Austria.;Principal Liechtenstein, Private Univ, Triesen, Liechtenstein.,Private University of the Principality of Liechtenstein4 aut
700	1	a Drexel, Heinzu Heart & Lungs Div, Dept Cardiol, Utrecht, Netherlands.;Univ Florida, Dept Pharmacotherapy, Colleges Pharm, Gainesville, FL USA.;Univ Florida, Dept Pharmacotherapy, Translat Res & Ctr Pharmac, Gainesville, FL USA.;Vorarlberg Inst Vasc Invest & Treatment, Feldkirch, Austria.;Principal Liechtenstein, Private Univ, Triesen, Liechtenstein.;Acad Teaching Hosp Feldkirch, Dept Med & Cardiol, Feldkirch, Austria.;Drexel Univ, Coll Med, Philadelphia, PA USA.,Drexel University4 aut
700	1	a Muendlein, Axelu Vorarlberg Inst Vasc Invest & Treatment, Feldkirch, Austria.,Vorarlberg Institute for Vascular Investigation and Treatment4 aut
700	1	a Braund, Peter S.u Univ Florida, Dept Pharmacotherapy, Colleges Pharm, Gainesville, FL USA.;Univ Florida, Dept Pharmacotherapy, Translat Res & Ctr Pharmac, Gainesville, FL USA.;Univ Leicester, Glenfield Hosp, Dept Cardiovascular Sci, BHF Cardiovascular Res Ctr, Leicester, Leics, England.,Glenfield Hospital4 aut
700	1	a Nelson, Christopher P.u Univ Leicester, Glenfield Hosp, Dept Cardiovascular Sci, BHF Cardiovascular Res Ctr, Leicester, Leics, England.,Glenfield Hospital4 aut
700	1	a Samani, Nilesh J.u Heart & Lungs Div, Dept Cardiol, Utrecht, Netherlands.;Leicester NIHR Biomed Res Unit Cardiovasc Dis, Glenfield Hosp, Leicester, Leics, England.;Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden.;Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden.4 aut
700	1	a Kofink, Danielu University Medical Center Utrecht4 aut
700	1	a Hoefer, Imo E.u University Medical Center Utrecht4 aut
700	1	a Pasterkamp, Gerardu University Medical Center Utrecht4 aut
700	1	a Quyyumi, Arshed A.u Emory Univ, Emory Clin Cardiovascular Res Inst, Atlanta, GA USA.;Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden.;Uppsala Univ, Dept Med Sci, Clin Chem, Uppsala, Sweden.4 aut
700	1	a Ko, Yi-Anu Emory Clinic4 aut
700	1	a Hartiala, Jaana A.u Univ Southern Calif, Los Angeles, CA USA.;Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden.,University of Southern California4 aut
700	1	a Allayee, Hoomanu University of Southern California4 aut
700	1	a Tang, W. H. Wilsonu Cleveland Clinic Foundation4 aut
700	1	a Hazen, Stanley L.u Heidelberg Univ, Dept Med, Mannheim, Germany.,Cleveland Clinic Foundation4 aut
700	1	a Eriksson, Niclas,d 1978-u Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)nieri103
700	1	a Held, Claes,d 1956-u Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)clahe947
700	1	a Hagström, Emilu Uppsala University,Uppsala universitet,Kardiologi4 aut0 (Swepub:uu)emhag677
700	1	a Wallentin, Lars,d 1943-u Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Uppsala University Hospital4 aut0 (Swepub:uu)larswall
700	1	a Åkerblom, Axel,d 1977-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)axeak985
700	1	a Siegbahn, A,d 1947-u Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)agsie424
700	1	a Karp, Igoru Univ Western Ontario, Schulich Sch Med & Dent, Dept Epidemiol & Biostat, London, England.,University of Western Ontario4 aut
700	1	a Labos, Christopheru Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden.;McGill Univ, Dept Med, Montreal, PQ, Canada.,McGill University4 aut
700	1	a Pilote, Louiseu McGill Univ, Dept Med, Montreal, PQ, Canada.,McGill University4 aut
700	1	a Engert, James C.u McGill Univ, Dept Med, Montreal, PQ, Canada.,McGill University4 aut
700	1	a Brophy, James M.u McGill Univ, Dept Med, Montreal, PQ, Canada.;Univ Laval, Dept Med, Laval, PQ, Canada.,McGill University4 aut
700	1	a Thanassoulis, Georgeu McGill Univ, Dept Med, Montreal, PQ, Canada.,McGill University4 aut
700	1	a Bogaty, Peteru McGill Univ, Dept Med, Montreal, PQ, Canada.,Laval University4 aut
700	1	a Szczeklik, Wojciechu Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden.;Jagielonian Univ, Coll Med, Krakow, Poland.,Jagiellonian University4 aut
700	1	a Kaczor, Marcinu Jagielonian Univ, Coll Med, Krakow, Poland.,Jagiellonian University4 aut
700	1	a Sanak, Mareku Jagielonian Univ, Coll Med, Krakow, Poland.4 aut
700	1	a Virani, Salim S.u Baylor Coll Med, Cardiol Sect, Michael DeBakey Vet Affairs Med Ctr, Houston, TX USA.,Baylor College of Medicine4 aut
700	1	a Ballantyne, Christie M.u Baylor Coll Med, Sect Cardiovasc, Dept Med, Houston, TX USA.,Baylor College of Medicine4 aut
700	1	a Lee, Vei-Veiu Texas Heart Inst, Dept Biostat 7, Houston, TX USA.,Texas Heart Institute4 aut
700	1	a Boerwinkle, Ericu Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden.;Univ Texas Houston, Sch Publ Hlth, Houston, TX USA.,University of Texas4 aut
700	1	a Holmes, Michael V.u Univ Oxford, Med Res Council Populat Hlth Res Unit, Oxford, England.;Univ Oxford, Natl Inst Hlth Res Oxford Biomed Res Ctr, Oxford, England.,University of Oxford4 aut
700	1	a Horne, Benjamin D.u Univ Oxford, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Epidemiol Studies Unit CTSU, Nuffield Dept Populat Hlth, Oxford, England.,University of Utah4 aut
700	1	a Hingorani, Aroonu University College London4 aut
700	1	a Asselbergs, Folkert W.u Durrer Ctr Cardiogenet Res, ICIN, Utrecht, Netherlands.,Interuniversity Cardiology Institute of the Netherlands4 aut
700	1	a Patel, Riyaz S.u University College London4 aut
700	1	a Kraemer, Bernhard K.u Heidelberg University4 aut
700	1	a Scharnagl, Hubertu Medical University of Graz4 aut
700	1	a Fliser, Danilou Saarland University4 aut
700	1	a Maerz, Winfriedu Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany.;Synlab Acad, Synlab Holding, Mannheim, Germany.,Synlab Academy4 aut
700	1	a Speer, Thimoteusu Saarland University4 aut
710	2	a Saarland Univ Hosp, Dept Internal Med 4, Homburg, Germany.b Saarland University4 org
773	0	t The Lancet Diabetes and Endocrinologyd : ELSEVIER SCIENCE INCg 5:7, s. 534-543q 5:7<534-543x 2213-8587x 2213-8595
856	4	u http://dx.doi.org/10.1016/S2213-8587(17)30096-7y FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-329628
856	4 8	u https://doi.org/10.1016/S2213-8587(17)30096-7
856	4 8	u https://lup.lub.lu.se/record/090d445f-f2d3-40b8-b9c9-abe964a82c78

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Av författaren/redakt...: Zewinger, Stephe ...; Kleber, Marcus E ...; Tragante, Vinici ...; McCubrey, Raymon ...; Schmidt, Amand F ...; Direk, Kenan; visa fler...; Laufs, Ulrich; Werner, Christia ...; Koenig, Wolfgang; Rothenbacher, Di ...; Mons, Ute; Breitling, Lutz ...; Brenner, Herrman ...; Jennings, Richar ...; Petrakis, Ioanni ...; Triem, Sarah; Klug, Mira; Filips, Alexandr ...; Blankenberg, Ste ...; Waldeyer, Christ ...; Sinning, Christo ...; Schnabel, Renate ...; Lackner, Karl J.; Vlachopoulou, Ef ...; Nygard, Ottar; Svingen, Gard Fr ...; Pedersen, Eva Ri ...; Tell, Grethe S.; Sinisalo, Juha; Nieminen, Markku ...; Laaksonen, Reijo; Trompet, Stella; Smit, Roelof A. ...; Sattar, Naveed; Jukema, J. Woute ...; Groesdonk, Heinr ...; Delgado, Graciel ...; Stojakovic, Tatj ...; Pilbrow, Anna P.; Cameron, Vicky A ...; Richards, A. Mar ...; Doughty, Robert ...; Gong, Yan; Cooper-DeHoff, R ...; Johnson, Julie; Scholz, Markus; Beutner, Frank; Thiery, Joachim; Smith, Gustav; Vilmundarson, Ra ...; McPherson, Ruth; Stewart, Alexand ...; Cresci, Sharon; Lenzini, Petra A ...; Spertus, John A.; Olivieri, Olivie ...; Girelli, Domenic ...; Martinelli, Nico ...; Leiherer, Andrea ...; Saely, Christoph ...; Drexel, Heinz; Muendlein, Axel; Braund, Peter S.; Nelson, Christop ...; Samani, Nilesh J ...; Kofink, Daniel; Hoefer, Imo E.; Pasterkamp, Gera ...; Quyyumi, Arshed ...; Ko, Yi-An; Hartiala, Jaana ...; Allayee, Hooman; Tang, W. H. Wils ...; Hazen, Stanley L ...; Eriksson, Niclas ...; Held, Claes, 195 ...; Hagström, Emil; Wallentin, Lars, ...; Åkerblom, Axel, ...; Siegbahn, A, 194 ...; Karp, Igor; Labos, Christoph ...; Pilote, Louise; Engert, James C.; Brophy, James M.; Thanassoulis, Ge ...; Bogaty, Peter; Szczeklik, Wojci ...; Kaczor, Marcin; Sanak, Marek; Virani, Salim S.; Ballantyne, Chri ...; Lee, Vei-Vei; Boerwinkle, Eric; Holmes, Michael ...; Horne, Benjamin ...; Hingorani, Aroon; Asselbergs, Folk ...; Patel, Riyaz S.; Kraemer, Bernhar ...; Scharnagl, Huber ...; Fliser, Danilo; Maerz, Winfried; Speer, Thimoteus; visa färre...

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