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Erythropoietic effe...
Erythropoietic effects of vadadustat in patients with anemia associated with chronic kidney disease
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- Koury, Mark J. (författare)
- Division of Hematology/Oncology, Department of Medicine Vanderbilt University Medical Center Nashville TN US,Division of Hematology/Oncology, Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA
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- Agarwal, Rajiv (författare)
- Department of Medicine, Division of Nephrology Indiana University School of Medicine Indianapolis Indiana USA
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- Chertow, Glenn M. (författare)
- Stanford University School of Medicine Palo Alto CA US,Stanford University School of Medicine Palo Alto California USA
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- Eckardt, Kai‐Uwe (författare)
- Department of Nephrology and Medical Intensive Care Charité – Universitätsmedizin Berlin Berlin Germany
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- Fishbane, Steven (författare)
- Division of Nephrology, Department of Medicine Hofstra Northwell School of Medicine Great Neck New York USA
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- Ganz, Tomas (författare)
- Department of Medicine and Pathology, David Geffen School of Medicine University of California Los Angeles California USA
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- Haase, Volker H., Professor (författare)
- Uppsala universitet,Integrativ Fysiologi,Department of Medicine Vanderbilt University Medical Center Nashville TN US.,Institutionen för medicinsk cellbiologi,Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA.
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- Hanudel, Mark R. (författare)
- Department of Pediatrics, Division of Pediatric Nephrology, David Geffen School of Medicine University of California Los Angeles California USA
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- Parfrey, Patrick S. (författare)
- Department of Medicine Memorial University St John's Newfoundland and Labrador Canada
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- Pergola, Pablo E. (författare)
- Renal Associates PA San Antonio TX US,Renal Associates PA San Antonio Texas USA
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- Roy‐Chaudhury, Prabir (författare)
- W.G. (Bill) Hefner VA Medical Center Salisbury North Carolina USA
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- Tumlin, James A. (författare)
- Emory University School of Medicine Atlanta GA US,Emory University School of Medicine Atlanta Georgia USA
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- Anders, Robert (författare)
- Akebia Therapeutics, Inc. Cambridge MA US,Akebia Therapeutics, Inc. Cambridge Massachusetts USA
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- Farag, Youssef M. K. (författare)
- Akebia Therapeutics, Inc. Cambridge MA US,Akebia Therapeutics, Inc. Cambridge Massachusetts USA
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- Luo, Wenli (författare)
- Akebia Therapeutics, Inc. Cambridge MA US,Akebia Therapeutics, Inc. Cambridge Massachusetts USA
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- Minga, Todd (författare)
- Akebia Therapeutics, Inc. Cambridge MA US,Akebia Therapeutics, Inc. Cambridge Massachusetts USA
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- Solinsky, Christine (författare)
- Akebia Therapeutics, Inc. Cambridge MA US,Akebia Therapeutics, Inc. Cambridge Massachusetts USA
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- Vargo, Dennis L. (författare)
- Akebia Therapeutics, Inc. Cambridge MA US,Akebia Therapeutics, Inc. Cambridge Massachusetts USA
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- Winkelmayer, Wolfgang C. (författare)
- Section of Nephrology Baylor College of Medicine Houston TX US,Section of Nephrology Baylor College of Medicine Houston Texas USA
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(creator_code:org_t)
- 2022-07-15
- 2022
- Engelska.
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Ingår i: American Journal of Hematology. - : John Wiley & Sons. - 0361-8609 .- 1096-8652. ; 97:9, s. 1178-1188
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Patients with chronic kidney disease (CKD) develop anemia largely because of inappropriately low erythropoietin (EPO) production and insufficient iron available to erythroid precursors. In four phase 3, randomized, open-label, clinical trials in dialysis-dependent and non–dialysis-dependent patients with CKD and anemia, the hypoxia-inducible factor prolyl hydroxylase inhibitor, vadadustat, was noninferior to the erythropoiesis-stimulating agent, darbepoetin alfa, in increasing and maintaining target hemoglobin concentrations. In these trials, vadadustat increased the concentrations of serum EPO, the numbers of circulating erythrocytes, and the numbers of circulating reticulocytes. Achieved hemoglobin concentrations were similar in patients treated with either vadadustat or darbepoetin alfa, but compared with patients receiving darbepoetin alfa, those receiving vadadustat had erythrocytes with increased mean corpuscular volume and mean corpuscular hemoglobin, while the red cell distribution width was decreased. Increased serum transferrin concentrations, as measured by total iron-binding capacity, combined with stable serum iron concentrations, resulted in decreased transferrin saturation in patients randomized to vadadustat compared with patients randomized to darbepoetin alfa. The decreases in transferrin saturation were associated with relatively greater declines in serum hepcidin and ferritin in patients receiving vadadustat compared with those receiving darbepoetin alfa. These results for serum transferrin saturation, hepcidin, ferritin, and erythrocyte indices were consistent with improved iron availability in the patients receiving vadadustat. Thus, overall, vadadustat had beneficial effects on three aspects of erythropoiesis in patients with anemia associated with CKD: increased endogenous EPO production, improved iron availability to erythroid cells, and increased reticulocytes in the circulation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- chronic kidney disease
- anemia
- iron metabolism
- vadadustat
- HIF
- hypoxia
- Medicinsk vetenskap
- Medical Science
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Koury, Mark J.
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Agarwal, Rajiv
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Chertow, Glenn M ...
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Eckardt, Kai‐Uwe
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Fishbane, Steven
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Ganz, Tomas
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visa fler...
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Haase, Volker H. ...
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Hanudel, Mark R.
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Parfrey, Patrick ...
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Pergola, Pablo E ...
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Roy‐Chaudhury, P ...
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Tumlin, James A.
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Anders, Robert
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Farag, Youssef M ...
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Luo, Wenli
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Minga, Todd
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Solinsky, Christ ...
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Vargo, Dennis L.
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Winkelmayer, Wol ...
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