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Sökning: WFRF:(Gunnarsson R) > ECOdrug: A database...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005483naa a2200853 4500
001oai:gup.ub.gu.se/264382
003SwePub
008240528s2018 | |||||||||||000 ||eng|
009oai:research.chalmers.se:cb16d738-c60b-4129-9a12-48256b9b81c5
0247 a https://gup.ub.gu.se/publication/2643822 URI
0247 a https://doi.org/10.1093/nar/gkx10242 DOI
0247 a https://research.chalmers.se/publication/5003992 URI
0247 a https://research.chalmers.se/publication/5003312 URI
040 a (SwePub)gud (SwePub)cth
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Verbruggen, B.u University of Exeter4 aut
2451 0a ECOdrug: A database connecting drugs and conservation of their targets across species
264 c 2017-11-11
264 1b Oxford University Press (OUP),c 2018
520 a Pharmaceuticals are designed to interact with specific molecular targets in humans and these targets generally have orthologs in other species. This provides opportunities for the drug discovery community to use alternative model species for drug development. It also means, however, there is potential for mode of action related effects in non-target wildlife species as many pharmaceuticals reach the environment through patient use and manufacturing wastes. Acquiring insight in drug target ortholog predictions across species and taxonomic groups has proven difficult because of the lack of an optimal strategy and because necessary information is spread across multiple and diverse sources and platforms. We introduce a new research platform tool, ECOdrug, that reliably connects drugs to their protein targets across divergent species. It harmonizes ortholog predictions from multiple sources via a simple user interface underpinning critical applications for a wide range of studies in pharmacology, ecotoxicology and comparative evolutionary biology. ECOdrug can be used to identify species with drug targets and identify drugs that interact with those targets. As such, it can be applied to support intelligent targeted drug safety testing by ensuring appropriate and relevant species are selected in ecological risk assessments. ECOdrug is freely accessible and available at: Http://www.ecodrug.org. © 2017 The Author(s).
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng
650 7a NATURVETENSKAPx Data- och informationsvetenskapx Bioinformatik0 (SwePub)102032 hsv//swe
650 7a NATURAL SCIENCESx Computer and Information Sciencesx Bioinformatics0 (SwePub)102032 hsv//eng
650 7a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng
653 a atorvastatin
653 a dexlansoprazole
653 a esomeprazole
653 a hydroxymethylglutaryl coenzyme A reductase inhibitor
653 a mevinolin
653 a omeprazole
653 a rosuvastatin
653 a accuracy
653 a Article
653 a Chlamydomonas reinhardtii
653 a cholesterol synthesis
653 a Daphnia
653 a data analysis
653 a drug database
653 a drug efficacy
653 a drug information
653 a drug research
653 a drug safety
653 a drug screening
653 a drug targeting
653 a information processing
653 a information retrieval
653 a Lemna gibba
653 a nonhuman
653 a prediction
653 a priority journal
653 a protein targeting
653 a reliability
653 a toxicity testing
7001 a Gunnarsson, L.u University of Exeter4 aut
7001 a Kristiansson, Erik,d 1978u Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)erikkr
7001 a Österlund, Tobias,d 1984u Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)tobiaso
7001 a Owen, S. F.4 aut
7001 a Snape, J. R.u The University of Warwick4 aut
7001 a Tyler, C. R.u University of Exeter4 aut
7102 a University of Exeterb Institutionen för matematiska vetenskaper4 org
7730 t Nucleic Acids Researchd : Oxford University Press (OUP)g 46:D1q 46:D1x 0305-1048x 1362-4962
8564 u https://academic.oup.com/nar/article-pdf/46/D1/D930/23162040/gkx1024.pdf
8564 u https://research.chalmers.se/publication/500331/file/500331_Fulltext.pdfx primaryx freey FULLTEXT
8564 8u https://gup.ub.gu.se/publication/264382
8564 8u https://doi.org/10.1093/nar/gkx1024
8564 8u https://research.chalmers.se/publication/500399
8564 8u https://research.chalmers.se/publication/500331

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