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  • Freund-Levi, Yvonne,1956-Divisions of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Huddinge, Stockholm (author)

Effects of omega-3 fatty acids on inflammatory markers in cerebrospinal fluid and plasma in Alzheimer's disease : the OmegAD study

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-05-12
  • S. Karger,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-74159
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-74159URI
  • https://doi.org/10.1159/000218081DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122777URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:118784253URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies:Stockholm County Council and Karolinska Institutet  Funds of Capio  Stiftelsen Gamla Tjänarinnor  Swedish Alzheimer Foundation  Odd Fellow  Swedish Nutrition Foundation  Gun och Bertil Stohnes Stiftelse  Swedish Society of Physicians and Lion's Sweden  Pronova Biocare A/S, Lysaker, Norway 
  • BACKGROUND: omega-3 fatty acids (omega-3 FAs) found in dietary fish or fish oils are anti-inflammatory agents that may influence Alzheimer's disease (AD).OBJECTIVE: To study the effects of dietary omega-3 FA supplementation on inflammatory markers in cerebrospinal fluid (CSF) and plasma from patients with mild to moderate AD.METHODS: Thirty-five patients (70.3 +/- 8.2 years) were randomized to a daily intake of 2.3 g omega-3 FAs or placebo for 6 months. The inflammatory markers interleukin (IL)-6, tumour necrosis factor-alpha and soluble interleukin-1 receptor type II (sIL-1RII) were analysed in CSF and plasma at baseline and at 6 months. The AD markers tau-protein, hyperphosphorylated tau-protein and beta-amyloid (Abeta(1-42)) were assessed in CSF. High-sensitivity C-reactive protein was assessed in plasma. A possible relation to the APOE genotype was investigated.RESULTS: There was no significant treatment effect of omega-3 FAs on inflammatory and AD biomarkers in CSF or on inflammatory markers in plasma, nor was there any relation with APOE. A significant correlation was observed at baseline between sIL-1RII and Abeta(1-42) levels in CSF.CONCLUSIONS: Treatment of AD patients with omega-3 FAs for 6 months did not influence inflammatory or biomarkers in CSF or plasma. The correlation between sIL-1RII and Abeta(1-42) may reflect the reciprocal interactions between IL-1 and Abeta peptides.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hjorth, ErikKarolinska Institutet (author)
  • Lindberg, CatharinaDivisions of Neurodegeneration, Department of Neurobiology, Care Sciences and Society (NVS), Huddinge, Stockholm (author)
  • Cederholm, TommyKarolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)tomce419 (author)
  • Faxen-Irving, GerdKarolinska Institutet (author)
  • Vedin, IngerKarolinska Institutet (author)
  • Palmblad, JanKarolinska Institutet (author)
  • Wahlund, Lars-OlofKarolinska Institutet (author)
  • Schultzberg, MarianneKarolinska Institutet (author)
  • Basun, HansUppsala universitet,Geriatrik(Swepub:uu)habas169 (author)
  • Eriksdotter Jönhagen, MariaKarolinska Institutet (author)
  • Karolinska InstitutetDivisions of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Huddinge, Stockholm (creator_code:org_t)

Related titles

  • In:Dementia and Geriatric Cognitive Disorders: S. Karger27:5, s. 481-4901420-80081421-9824

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