Clinical Effectiveness of Liraglutide vs Sitagliptin on Glycemic Control and Body Weight in Patients with Type 2 Diabetes: A Retrospective Assessment in Sweden

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Clinical Effectiveness of Liraglutide vs Sitagliptin on Glycemic Control and Body Weight in Patients with Type 2 Diabetes: A Retrospective Assessment in Sweden

Lindh, Magnus, 1960 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,NU Hosp Grp, Dept Med, Trollhattan Uddevalla, Sweden.;Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.

Matsson, P. O. (författare): Domnarvet VC, Borlange, Sweden.

Linder, R. (författare): Pygargus, Stockholm, Sweden.

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Svenningsson, Irene, 1957 (författare): Primary Hlth Care, Res & Dev Unit, Narhalsan, Vanersborg, Sweden.

Jorgensen, L. (författare): IMS Hlth, Stockholm, Sweden.

Ploug, U. J. (författare): Novo Nordisk AS, Soborg, Denmark.

Gydesen, H. (författare): Novo Nordisk AS, Soborg, Denmark.

Dorkhan, M. (författare): Novo Nordisk Scandinavia AB, Malmo, Sweden.

Larsen, S. (författare): Novo Nordisk Scandinavia AB, Malmo, Sweden.

Johansson, Gunnar (författare): Uppsala universitet,Allmänmedicin och preventivmedicin

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2016-05-23
2016
Engelska.
Ingår i: Diabetes Therapy. - : Springer Science and Business Media LLC. - 1869-6953 .- 1869-6961. ; 7:2, s. 321-333

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Abstract Ämnesord

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Introduction: The aim of the present study was to use real-world data from Swedish primary-care and national registries to understand clinical outcomes in patients with Type 2 diabetes (T2D) treated with liraglutide in clinical practice, and to compare with data from those treated with sitagliptin. Methods: This was a non-interventional, retrospective study conducted between February 2014 and September 2014 using T2D patient data from Swedish primary-care centers and national healthcare registries. The primary objective was to assess the effectiveness of liraglutide in control of glycemia and body weight in clinical practice (stage 1). The secondary objective was to compare the clinical effectiveness of liraglutide with sitagliptin on glycemic control and body weight in clinical practice in a propensity-score-matched population (stage 2). Results: In stage 1 (n = 402), 39.4% of patients treated with liraglutide achieved >= 1.0% (10.9 mmol/mol) reduction in glycated hemoglobin (HbA1c) after 180 days of treatment and 54.9% achieved the target HbA1c of <7.0% (53.0 mmol/mol). Moreover, compared with baseline, 22.5% of patients treated with liraglutide achieved both >= 1.0% reduction in HbA1c and >= 3.0% reduction in body weight. In stage 2, a significantly greater proportion of patients receiving liraglutide (n = 180) than sitagliptin (n = 208) achieved >= 1.0% reduction in HbA1c [52.9% vs 33.5%, respectively (P = 0.0002)]. Mean body-weight loss was also significantly greater in patients receiving liraglutide vs sitagliptin [-3.5 vs -1.3 kg, respectively (P < 0.0001)]. Conclusion: This study provides real-world evidence from Sweden corroborating previous clinical trials that demonstrate greater efficacy of liraglutide over sitagliptin on glycemic control and body-weight reduction in patients with T2D.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

Liraglutide
Real-world evidence
Sitagliptin
Sweden
Type 2 diabetes
dipeptidyl peptidase-4 inhibitors
randomized controlled-trials
incretin-based therapies
receptor agonists
adverse events
primary-care
insulin
management
metformin
mellitus
Liraglutide

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Av författaren/redakt...: Lindh, Magnus, 1 ...; Matsson, P. O.; Linder, R.; Svenningsson, Ir ...; Jorgensen, L.; Ploug, U. J.; visa fler...; Gydesen, H.; Dorkhan, M.; Larsen, S.; Johansson, Gunna ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

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Av lärosätet: Göteborgs universitet; Uppsala universitet

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