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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06896naa a2201249 4500 | |
| 001 | oai:gup.ub.gu.se/283820 | |
| 003 | SwePub | |
| 008 | 240528s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2838202 URI |
| 024 | 7 | a https://doi.org/10.1038/s41379-019-0302-02 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Meagher, N. S.4 aut |
| 245 | 1 0 | a A combination of the immunohistochemical markers CK7 and SATB2 is highly sensitive and specific for distinguishing primary ovarian mucinous tumors from colorectal and appendiceal metastases |
| 264 | 1 | b Elsevier BV,c 2019 |
| 520 | a Primary ovarian mucinous tumors can be difficult to distinguish from metastatic gastrointestinal neoplasms by histology alone. The expected immunoprofile of a suspected metastatic lower gastrointestinal tumor is CK7−/CK20+/CDX2+/PAX8−. This study assesses the addition of a novel marker SATB2, to improve the diagnostic algorithm. A test cohort included 155 ovarian mucinous tumors (105 carcinomas and 50 borderline tumors) and 230 primary lower gastrointestinal neoplasms (123 colorectal adenocarcinomas and 107 appendiceal neoplasms). All cases were assessed for SATB2, PAX8 CK7, CK20, and CDX2 expression on tissue microarrays. Expression was scored in a 3-tier system as absent, focal (1–50% of tumor cells) and diffuse (>50% of tumor cells) and then categorized into either absent/present or nondiffuse/diffuse. SATB2 and PAX8 expression was further evaluated in ovarian tumors from an international cohort of 2876 patients (expansion cohort, including 159 mucinous carcinomas and 46 borderline mucinous tumors). The highest accuracy of an individual marker indistinguishing lower gastrointestinal from ovarian mucinous tumors was CK7 (91.7%, nondiffuse/diffuse cut-off) followed by SATB2 (88.8%, present/absent cut-off). The most effective combination was CK7 and SATB2 with accuracy of 95.3% using the 3-tier interpretation, absent/focal/diffuse. This combination outperformed the standard clinical set of CK7, CK20 and CDX2 (87.5%). Re-evaluation of outlier cases confirmed ovarian origin for all but one case. The accuracy of SATB2 was confirmed in the expansion cohort (91.5%). SATB2 expression was also detected in 15% of ovarian endometrioid carcinoma but less than 5% of other ovarian histotypes. A simple two marker combination of CK7 and SATB2 can distinguish lower gastrointestinal from ovarian primary mucinous tumors with greater than 95% accuracy. PAX8 and CDX2 have value as second-line markers. The utility of CK20 in this setting is low and this warrants replacement of this marker with SATB2 in clinical practice. © 2019, The Author(s), under exclusive licensc to United States & Canadian Academy of Pathology. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 700 | 1 | a Wang, L.4 aut |
| 700 | 1 | a Rambau, P. F.4 aut |
| 700 | 1 | a Intermaggio, M. P.4 aut |
| 700 | 1 | a Huntsman, D. G.4 aut |
| 700 | 1 | a Wilkens, L. R.4 aut |
| 700 | 1 | a El-Bahrawy, M. A.4 aut |
| 700 | 1 | a Ness, R. B.4 aut |
| 700 | 1 | a Odunsi, K.4 aut |
| 700 | 1 | a Steed, H.4 aut |
| 700 | 1 | a Herpel, E.4 aut |
| 700 | 1 | a Anglesio, M. S.4 aut |
| 700 | 1 | a Zhang, B.4 aut |
| 700 | 1 | a Lambie, N.4 aut |
| 700 | 1 | a Swerdlow, A. J.4 aut |
| 700 | 1 | a Lubiński, J.4 aut |
| 700 | 1 | a Vierkant, R. A.4 aut |
| 700 | 1 | a Goode, E. L.4 aut |
| 700 | 1 | a Menon, U.4 aut |
| 700 | 1 | a Toloczko-Grabarek, A.4 aut |
| 700 | 1 | a Oszurek, O.4 aut |
| 700 | 1 | a Bilic, S.4 aut |
| 700 | 1 | a Talhouk, A.4 aut |
| 700 | 1 | a García-Closas, M.4 aut |
| 700 | 1 | a Wang, Q.4 aut |
| 700 | 1 | a Tan, A.4 aut |
| 700 | 1 | a Farrell, R.4 aut |
| 700 | 1 | a Kennedy, C. J.4 aut |
| 700 | 1 | a Jimenez-Linan, M.4 aut |
| 700 | 1 | a Sundfeldt, Karin,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Sahlgrenska Cancer Center,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xsukar |
| 700 | 1 | a Etter, J. L.4 aut |
| 700 | 1 | a Menkiszak, J.4 aut |
| 700 | 1 | a Goodman, M. T.4 aut |
| 700 | 1 | a Klonowski, P.4 aut |
| 700 | 1 | a Leung, Y.4 aut |
| 700 | 1 | a Winham, S. J.4 aut |
| 700 | 1 | a Moysich, K. B.4 aut |
| 700 | 1 | a Behrens, S.4 aut |
| 700 | 1 | a Kluz, T.4 aut |
| 700 | 1 | a Edwards, R. P.4 aut |
| 700 | 1 | a Gronwald, J.4 aut |
| 700 | 1 | a Modugno, F.4 aut |
| 700 | 1 | a Hernandez, B. Y.4 aut |
| 700 | 1 | a Chow, C.4 aut |
| 700 | 1 | a Kelemen, L. E.4 aut |
| 700 | 1 | a Keeney, G. L.4 aut |
| 700 | 1 | a Carney, M. E.4 aut |
| 700 | 1 | a Natanzon, Y.4 aut |
| 700 | 1 | a Robertson, G.4 aut |
| 700 | 1 | a Sharma, R.4 aut |
| 700 | 1 | a Gayther, S. A.4 aut |
| 700 | 1 | a Alsop, J.4 aut |
| 700 | 1 | a Luk, H.4 aut |
| 700 | 1 | a Karpinskyj, C.4 aut |
| 700 | 1 | a Campbell, I.4 aut |
| 700 | 1 | a Sinn, P.4 aut |
| 700 | 1 | a Gentry-Maharaj, A.4 aut |
| 700 | 1 | a Coulson, P.4 aut |
| 700 | 1 | a Chang-Claude, J.4 aut |
| 700 | 1 | a Shah, M.4 aut |
| 700 | 1 | a Widschwendter, M.4 aut |
| 700 | 1 | a Tang, K.4 aut |
| 700 | 1 | a Schoemaker, M. J.4 aut |
| 700 | 1 | a Koziak, J. M.4 aut |
| 700 | 1 | a Cook, L. S.4 aut |
| 700 | 1 | a Brenton, J. D.4 aut |
| 700 | 1 | a Daley, F.4 aut |
| 700 | 1 | a Kristjansdottir, Björgu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Sahlgrenska Cancer Center,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xkribj |
| 700 | 1 | a Mateoiu, Constantinau Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine4 aut |
| 700 | 1 | a Larson, M. C.4 aut |
| 700 | 1 | a Harnett, P. R.4 aut |
| 700 | 1 | a Jung, A.4 aut |
| 700 | 1 | a deFazio, A.4 aut |
| 700 | 1 | a Gorringe, K. L.4 aut |
| 700 | 1 | a Pharoah, P. D. P.4 aut |
| 700 | 1 | a Minoo, P.4 aut |
| 700 | 1 | a Stewart, C.4 aut |
| 700 | 1 | a Bathe, O. F.4 aut |
| 700 | 1 | a Gui, X.4 aut |
| 700 | 1 | a Cohen, P.4 aut |
| 700 | 1 | a Ramus, S. J.4 aut |
| 700 | 1 | a Köbel, M.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi4 org |
| 773 | 0 | t Modern Pathologyd : Elsevier BVg 32, s. 1834-1846q 32<1834-1846x 0893-3952 |
| 856 | 4 | u https://www.nature.com/articles/s41379-019-0302-0.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/283820 |
| 856 | 4 8 | u https://doi.org/10.1038/s41379-019-0302-0 |
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- Meagher, N. S.
- Wang, L.
- Rambau, P. F.
- Intermaggio, M. ...
- Huntsman, D. G.
- Wilkens, L. R.
- visa fler...
- El-Bahrawy, M. A ...
- Ness, R. B.
- Odunsi, K.
- Steed, H.
- Herpel, E.
- Anglesio, M. S.
- Zhang, B.
- Lambie, N.
- Swerdlow, A. J.
- Lubiński, J.
- Vierkant, R. A.
- Goode, E. L.
- Menon, U.
- Toloczko-Grabare ...
- Oszurek, O.
- Bilic, S.
- Talhouk, A.
- García-Closas, M ...
- Wang, Q.
- Tan, A.
- Farrell, R.
- Kennedy, C. J.
- Jimenez-Linan, M ...
- Sundfeldt, Karin ...
- Etter, J. L.
- Menkiszak, J.
- Goodman, M. T.
- Klonowski, P.
- Leung, Y.
- Winham, S. J.
- Moysich, K. B.
- Behrens, S.
- Kluz, T.
- Edwards, R. P.
- Gronwald, J.
- Modugno, F.
- Hernandez, B. Y.
- Chow, C.
- Kelemen, L. E.
- Keeney, G. L.
- Carney, M. E.
- Natanzon, Y.
- Robertson, G.
- Sharma, R.
- Gayther, S. A.
- Alsop, J.
- Luk, H.
- Karpinskyj, C.
- Campbell, I.
- Sinn, P.
- Gentry-Maharaj, ...
- Coulson, P.
- Chang-Claude, J.
- Shah, M.
- Widschwendter, M ...
- Tang, K.
- Schoemaker, M. J ...
- Koziak, J. M.
- Cook, L. S.
- Brenton, J. D.
- Daley, F.
- Kristjansdottir, ...
- Mateoiu, Constan ...
- Larson, M. C.
- Harnett, P. R.
- Jung, A.
- deFazio, A.
- Gorringe, K. L.
- Pharoah, P. D. P ...
- Minoo, P.
- Stewart, C.
- Bathe, O. F.
- Gui, X.
- Cohen, P.
- Ramus, S. J.
- Köbel, M.
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