WFRF:(Sjoberg Daniel)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04025naa a2200481 4500 | |
| 001 | oai:lup.lub.lu.se:e8804fdc-15de-47fa-a16d-422c664e162d | |
| 003 | SwePub | |
| 008 | 170216s2017 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/e8804fdc-15de-47fa-a16d-422c664e162d2 URI |
| 024 | 7 | a https://doi.org/10.1016/j.juro.2016.09.0862 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Vickers, Andrew4 aut |
| 245 | 1 0 | a Properties of the 4-Kallikrein Panel Outside the Diagnostic Gray Zone : Meta-Analysis of Patients with Positive Digital Rectal Examination or Prostate Specific Antigen 10 ng/ml and Above |
| 264 | 1 | b Ovid Technologies (Wolters Kluwer Health),c 2017 |
| 520 | a Purpose: The 4-kallikrein panel, commercially available as the 4Kscore™, is a reflex test for prostate cancer early detection that has been extensively validated in multiple international cohorts. It has been suggested that use of such reflex tests be limited to those with prostate specific antigen less than 10 ng/ml and negative digital rectal examination. We aimed to determine the value of the panel in men outside this "diagnostic gray zone.". Materials and Methods: We performed an individual patient data meta-analysis using data from prior studies on the 4-kallikrein panel. We calculated the properties of the panel for predicting high grade (Gleason 7+) cancer in a subgroup of men with either positive digital rectal examination or prostate specific antigen 10 to 25 ng/ml. Results: A total 2,891 men from 8 cohorts were included. An important proportion of patients, including 32% in the United States validation study, had prostate specific antigen 10 to 25 ng/ml or a positive digital rectal examination. For men with prostate specific antigen 10 to 25 ng/ml the fixed-effects estimate for the discrimination of the kallikrein model was 0.84 vs 0.69 for the base model (difference 0.128, 95% CI 0.098-0.159). In the positive digital rectal examination group discrimination was 0.82 vs 0.72 (difference 0.092, 95% CI 0.069-0.115). Decision analysis showed a clinical net benefit for use of the panel in this subgroup with a reduction in biopsy rates of about 20% and only a small number of high grade cancers missed, fewer than 3% of those not biopsied. Conclusion: The use of the kallikrein panel in men with a positive digital rectal examination or prostate specific antigen 10 to 25 ng/ml is justified. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a Digital rectal examination | |
| 653 | a Early detection of cancer | |
| 653 | a Kallikreins | |
| 653 | a Prostate-specific antigen | |
| 653 | a Prostatic neoplasms | |
| 700 | 1 | a Vertosick, Emily A4 aut |
| 700 | 1 | a Sjoberg, Daniel4 aut |
| 700 | 1 | a Roobol, Monique J4 aut |
| 700 | 1 | a Hamdy, Freddie4 aut |
| 700 | 1 | a Neal, David E4 aut |
| 700 | 1 | a Bjartell, Andersu Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)kir-abj |
| 700 | 1 | a Hugosson, Jonas4 aut |
| 700 | 1 | a Donovan, Jenny L4 aut |
| 700 | 1 | a Villers, Arnauld4 aut |
| 700 | 1 | a Zappala, Stephen4 aut |
| 700 | 1 | a Lilja, Hans4 aut |
| 710 | 2 | a Urologisk cancerforskning, Malmöb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Journal of Urologyd : Ovid Technologies (Wolters Kluwer Health)g 197, s. 607-613q 197<607-613x 0022-5347x 1527-3792 |
| 856 | 4 | u http://dx.doi.org/10.1016/j.juro.2016.09.086y FULLTEXT |
| 856 | 4 | u https://europepmc.org/articles/pmc5315584?pdf=render |
| 856 | 4 8 | u https://lup.lub.lu.se/record/e8804fdc-15de-47fa-a16d-422c664e162d |
| 856 | 4 8 | u https://doi.org/10.1016/j.juro.2016.09.086 |
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