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Search: AMNE:(MEDICAL AND HEALTH SCIENCES Medical Biotechnology Biomaterials Science) > (2020-2024) > Long-term in vivo i...

Long-term in vivo integrity and safety of3D-bioprinted cartilaginous constructs

Apelgren, Peter (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för plastikkirurgi,Institute of Clinical Sciences, Department of Plastic Surgery,University of Gothenburg
Amoroso, Matteo, 1984 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för plastikkirurgi,Institute of Clinical Sciences, Department of Plastic Surgery,University of Gothenburg
Säljö, Karin, 1981 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för plastikkirurgi,Institute of Clinical Sciences, Department of Plastic Surgery,University of Gothenburg
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Lindahl, A. (author)
Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
Brantsing, C. (author)
Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
Strid Orrhult, Linnea, 1983 (author)
Chalmers tekniska högskola,Chalmers University of Technology
Markstedt, Kajsa, 1989 (author)
Chalmers tekniska högskola,Chalmers University of Technology
Gatenholm, Paul, 1956 (author)
Chalmers tekniska högskola,Chalmers University of Technology
Kölby, Lars, 1963 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för plastikkirurgi,Institute of Clinical Sciences, Department of Plastic Surgery,University of Gothenburg
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 (creator_code:org_t)
2020-07-06
2021
English.
In: Journal of Biomedical Materials Research Part B-Applied Biomaterials. - : Wiley. - 1552-4973 .- 1552-4981. ; 109:1, s. 126-136
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Long-term stability and biological safety are crucial for translation of 3D-bioprinting technology into clinical applications. Here, we addressed the long-term safety and stability issues associated with 3D-bioprinted constructs comprising a cellulose scaffold and human cells (chondrocytes and stem cells) over a period of 10 months in nude mice. Our findings showed that increasing unconfined compression strength over time significantly improved the mechanical stability of the cell-containing constructs relative to cell-free scaffolds. Additionally, the cell-free constructs exhibited a mean compressive stress and stiffness (compressive modulus) of 0.04 +/- 0.05 MPa and 0.14 +/- 0.18 MPa, respectively, whereas these values for the cell-containing constructs were 0.11 +/- 0.08 MPa (p= .019) and 0.53 +/- 0.59 MPa (p= .012), respectively. Moreover, histomorphologic analysis revealed that cartilage formed from the cell-containing constructs harbored an abundance of proliferating chondrocytes in clusters, and after 10 months, resembled native cartilage. Furthermore, extension of the experiment over the complete lifecycle of the animal model revealed no signs of ossification, fibrosis, necrosis, or implant-related tumor development in the 3D-bioprinted constructs. These findings confirm the in vivo biological safety and mechanical stability of 3D-bioprinted cartilaginous tissues and support their potential translation into clinical applications.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)
NATURVETENSKAP  -- Biologi -- Cellbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Cell Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Biomaterials Science (hsv//eng)

Keyword

3D-bioprinting
cartilage
chondrocytes
in vivo
long-term
nude mice
mesenchymal stem-cells
balb/c-nu mice
chondrogenic differentiation
regenerative medicine
spontaneous tumors
life-span
chondrocytes
reconstruction
proliferation
nanocellulose
Engineering
Materials Science
chondrocytes

Publication and Content Type

ref (subject category)
art (subject category)

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