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Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors
- Gonzalez, Patricia Verónica (författare)
-
- Schiöth, Helgi Birgir (författare)
- Uppsala universitet,Funktionell farmakologi
- Lasaga, Mercedes (författare)
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- Scimonelli, Teresa Nieves (författare)
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- (creator_code:org_t)
- Elsevier BV, 2009
- 2009
- Engelska.
- Ingår i: Brain, behavior, and immunity. - : Elsevier BV. - 0889-1591 .- 1090-2139. ; 23:6, s. 817-822
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Interleukin-1beta (IL-1beta) significantly influences memory consolidation. Treatments that raise the level of IL-1beta in the brain, given after training, impair contextual fear conditioning. The melanocortin alpha-MSH exerts potent anti-inflammatory actions by physiologically antagonizing the effect of pro-inflammatory cytokines. Five subtypes of melanocortin receptors (MC1R-MC5R) have been identified, with MC3R and MC4R predominating in the central nervous system. The present experiments show that injection of IL-1beta (5 ng/0.25 microl) in dorsal hippocampus up to 15 min after training decreased freezing during the contextual fear test. The treatment with IL-1beta (5 ng/0.25 microl) 12h after conditioning cause amnesia when animals were tested 7 days post training. Thus, our results also demonstrated that IL-1beta can influence persistence of long-term memory. We determined that animals previously injected with IL-1beta can acquire a new contextual fear memory, demonstrating that the hippocampus was not damaged. Treatment with alpha-MSH (0.05 microg/0.25 microl) blocked the effect of IL-1beta on contextual fear memory. Administration of the MC4 receptor antagonist HS014 (0.5 microg/0.25 microl) reversed the effect of alpha-MSH. However, treatment with gamma-MSH (0.5 microg/0.25 microl), an MC3 agonist, did not affect IL-1beta-induced impairment of memory consolidation. These results suggest that alpha-MSH, through central MC4R can inhibit the effect of IL-1beta on memory consolidation.
Nyckelord
- Interleukin-1 beta
- Melanocortins
- Melanocortin receptors
- Fear conditioning
- Memory consolidation
- Memory persistence
- Hippocampus
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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