Search: L773:1538 7445 OR L773:0008 5472
> (2000-2009) >
Deletion of laminin...
Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice
-
Zhou, ZJ (author)
-
Doi, M (author)
-
Wang, JM (author)
-
show more...
-
- Cao, RH (author)
- Karolinska Institutet
-
Liu, BH (author)
-
Chan, KM (author)
-
Kortesmaa, J (author)
-
- Sorokin, Lydia (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Cao, YH (author)
- Karolinska Institutet
-
- Tryggvason, K (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- 2004
- 2004
- English.
-
In: Cancer Research. - 1538-7445 .- 0008-5472. ; 64:12, s. 4059-4063
- Related links:
-
http://cancerres.aac... (free)
-
show more...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Laminin-8 (alpha4beta1gamma1) is one of the major laminin isoforms expressed in vascular endothelial basement membranes. Here we show that deletion of laminin-8 in mice affects angiogenesis under pathological conditions. Murine tumor models used in laminin alpha4-deficient mice results in hyperneovascularization and significant promotion of tumor growth and metastasis. The higher tumor growth rates in mutant mice correlate with decreased tumor cell apoptosis. Depletion of laminin alpha4 chain may alter the structure of vascular basement membranes, leading to increased angiogenesis. Our data suggest that the laminin-8 plays a critical role in the regulation of pathological angiogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Zhou, ZJ
-
Doi, M
-
Wang, JM
-
Cao, RH
-
Liu, BH
-
Chan, KM
-
show more...
-
Kortesmaa, J
-
Sorokin, Lydia
-
Cao, YH
-
Tryggvason, K
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Cancer Research
- By the university
-
Lund University
-
Karolinska Institutet