Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Isaacs M.) > Genomewide meta-ana...

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits

Teumer, A. (author): University of Greifswald

Qi, Q. (author): Yeshiva University,Harvard University

Nethander, Maria, 1980 (author): University of Gothenburg,Gothenburg University,Göteborgs universitet,Core Facilities, Bioinformatics,Centre for Bone and Arthritis Research,Core Facilities, Bioinformatics

Aschard, H. (author): Harvard University,New York University,EURAC Research

Bandinelli, S. (author)

Beekman, M. (author): Leiden University Medical Centre

Berndt, S. I. (author): National Cancer Institute, USA,Boston University

Bidlingmaier, M. (author): Ludwig-Maximilian University of Munich

Broer, L. (author): Erasmus University Medical Center

Cappola, A. (author): University of Pennsylvania

Ceda, G. P. (author): University of Parma

Chanock, S. (author): University of Greifswald

Chen, M. H. (author): Boston University,University of Parma,Parma University Hospital

Chen, T. C. (author): Boston University,National Institute on Aging, United States

Chen, Y. D. I. (author): University of California, Los Angeles

Chung, J. (author): Yeshiva University

Del Greco Miglianico, F. (author): University of Lübeck,EURAC Research

Eriksson, Joel (author): University of Gothenburg,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition

Ferrucci, L. (author): National Institute on Aging, United States,Icahn School of Medicine at Mount Sinai

Friedrich, N. (author): University of Greifswald

Gnewuch, C. (author): University of Regensburg

Goodarzi, M. O. (author): Cedars-Sinai Medical Center

Grarup, N. (author): University of Copenhagen

Guo, T. (author): Yeshiva University

Hammer, E. (author): University of Greifswald

Hayes, R. B. (author)

Hicks, A. A. (author)

Hofman, A. (author): Erasmus University Medical Center

Houwing-Duistermaat, J. J. (author): Leiden University Medical Centre

Hu, F. (author): Harvard University

Hunter, D. J. (author): Harvard University

Husemoen, L. L. (author): Research Centre for Prevention and Health

Isaacs, A. (author): Erasmus University Medical Center,Leiden University Medical Centre

Jacobs, K. B. (author): University of Greifswald

Lorentzon, Mattias, 1970 (author): Gothenburg University,Göteborgs universitet,University of Gothenburg,Massachusetts General Hospital,Harvard University,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition

Jansson, John-Olov, 1954 (author): University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology

Jehmlich, N. (author): University of Greifswald,Helmholtz Centre for Environmental Research (UFZ)

Johnson, S. (author): Yeshiva University

Juul, A. (author)

Karlsson, Magnus (author): Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups

Kilpelainen, T. O. (author): University of Copenhagen

Kovacs, P. (author): Leipzig University

Kraft, P. (author): Harvard University

Li, C. (author): Yeshiva University

Linneberg, A. (author)

Liu, Y. (author): Wake Forest University

Loos, R. J. F. (author)

Lorentzon, Mattias, 1970 (author): Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition

Lu, Y. (author): Icahn School of Medicine at Mount Sinai

Maggio, M. (author): University of Washington, Seattle,Erasmus University Medical Center,Leiden University Medical Centre

Magi, R. (author): University of Oxford,University of Tartu

Meigs, J. (author)

Mellström, Dan, 1945 (author): University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition

Nauck, M. (author): Harvard University,McGill University

Newman, A. B. (author): University of Pittsburgh

Pollak, M. N. (author)

Pramstaller, P. P. (author): EURAC Research,University of Lübeck,Leiden University Medical Centre

Prokopenko, I. (author): Imperial College London

Psaty, B. M. (author)

Reincke, M. (author): Ludwig-Maximilian University of Munich

Rimm, E. B. (author): Harvard University

Rotter, J. I. (author): University of California, Los Angeles

Saint Pierre, A. (author)

Schurmann, C. (author): Icahn School of Medicine at Mount Sinai

Seshadri, S. (author): Boston University

Sjögren, Klara, 1970 (author): University of Gothenburg,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition

Slagboom, P. E. (author)

Strickler, H. D. (author): Yeshiva University

Stumvoll, M. (author): Leipzig University

Suh, Y. (author): Guangdong Medical College,Yeshiva University

Sun, Q. (author)

Zhang, C. (author): National Institutes of Health, United States

Svensson, Johan, 1964 (author): University of Gothenburg,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition

Tanaka, T. (author)

Tare, A. (author): Yeshiva University

Tönjes, A. (author): Leipzig University

Uh, H. W. (author): Leiden University Medical Centre,University of Greifswald

Van Duijn, C. M. (author)

van Heemst, D. (author): Leiden University Medical Centre

Vandenput, Liesbeth, 1974 (author): University of Gothenburg,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition

Vasan, R. S. (author)

Völker, U. (author): University of Greifswald

Willems, Sara M. (author)

Ohlsson, Claes, 1965 (author): University of Gothenburg,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition

Wallaschofski, H. (author)

Kaplan, R. C. (author): Yeshiva University

show less...

(creator_code:org_t)

2016-06-21
2016
English.
In: Aging Cell. - : Wiley. - 1474-9718 .- 1474-9726. ; 15:5, s. 811-824

Related links:: https://onlinelibrar...; show more...; http://dx.doi.org/10... (free); https://gup.ub.gu.se...; https://doi.org/10.1...; https://lup.lub.lu.s...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer. Through genomewide association study of up to 30884 adults of European ancestry from 21 studies, we confirmed and extended the list of previously identified loci associated with circulating IGF-I and IGFBP-3 concentrations (IGF1, IGFBP3, GCKR, TNS3, GHSR, FOXO3, ASXL2, NUBP2/IGFALS, SORCS2, and CELSR2). Significant sex interactions, which were characterized by different genotype–phenotype associations between men and women, were found only for associations of IGFBP-3 concentrations with SNPs at the loci IGFBP3 and SORCS2. Analyses of SNPs, gene expression, and protein levels suggested that interplay between IGFBP3 and genes within the NUBP2 locus (IGFALS and HAGH) may affect circulating IGF-I and IGFBP-3 concentrations. The IGF-I-decreasing allele of SNP rs934073, which is an eQTL of ASXL2, was associated with lower adiposity and higher likelihood of survival beyond 90years. The known longevity-associated variant rs2153960 (FOXO3) was observed to be a genomewide significant SNP for IGF-I concentrations. Bioinformatics analysis suggested enrichment of putative regulatory elements among these IGF-I- and IGFBP-3-associated loci, particularly of rs646776 at CELSR2. In conclusion, this study identified several loci associated with circulating IGF-I and IGFBP-3 concentrations and provides clues to the potential role of the IGF axis in mediating effects of known (FOXO3) and novel (ASXL2) longevity-associated loci. © 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)

Keyword

aging
genomewide association study
growth hormone axis
IGF-I
IGFBP-3
longevity

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

Aging Cell (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Teumer, A.; Qi, Q.; Nethander, Maria ...; Aschard, H.; Bandinelli, S.; Beekman, M.; show more...; Berndt, S. I.; Bidlingmaier, M.; Broer, L.; Cappola, A.; Ceda, G. P.; Chanock, S.; Chen, M. H.; Chen, T. C.; Chen, Y. D. I.; Chung, J.; Del Greco Miglia ...; Eriksson, Joel; Ferrucci, L.; Friedrich, N.; Gnewuch, C.; Goodarzi, M. O.; Grarup, N.; Guo, T.; Hammer, E.; Hayes, R. B.; Hicks, A. A.; Hofman, A.; Houwing-Duisterm ...; Hu, F.; Hunter, D. J.; Husemoen, L. L.; Isaacs, A.; Jacobs, K. B.; Lorentzon, Matti ...; Jansson, John-Ol ...; Jehmlich, N.; Johnson, S.; Juul, A.; Karlsson, Magnus; Kilpelainen, T. ...; Kovacs, P.; Kraft, P.; Li, C.; Linneberg, A.; Liu, Y.; Loos, R. J. F.; Lu, Y.; Maggio, M.; Magi, R.; Meigs, J.; Mellström, Dan, ...; Nauck, M.; Newman, A. B.; Pollak, M. N.; Pramstaller, P. ...; Prokopenko, I.; Psaty, B. M.; Reincke, M.; Rimm, E. B.; Rotter, J. I.; Saint Pierre, A.; Schurmann, C.; Seshadri, S.; Sjögren, Klara, ...; Slagboom, P. E.; Strickler, H. D.; Stumvoll, M.; Suh, Y.; Sun, Q.; Zhang, C.; Svensson, Johan, ...; Tanaka, T.; Tare, A.; Tönjes, A.; Uh, H. W.; Van Duijn, C. M.; van Heemst, D.; Vandenput, Liesb ...; Vasan, R. S.; Völker, U.; Willems, Sara M.; Ohlsson, Claes, ...; Wallaschofski, H ...; Kaplan, R. C.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Medical Biotechn ...; and Medical Biotechn ...

Articles in the publication: Aging Cell

By the university: University of Gothenburg; Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se