WFRF:(Isaacs M.)
Sökning: WFRF:(Isaacs M.) > Genomewide meta-ana...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 11999naa a2201477 4500 | |
| 001 | oai:gup.ub.gu.se/244481 | |
| 003 | SwePub | |
| 008 | 240910s2016 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:a6671480-24db-4d09-a28f-7c879806584f | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2444812 URI |
| 024 | 7 | a https://doi.org/10.1111/acel.124902 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/a6671480-24db-4d09-a28f-7c879806584f2 URI |
| 040 | a (SwePub)gud (SwePub)lu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Teumer, A.u University of Greifswald4 aut |
| 245 | 1 0 | a Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits |
| 264 | c 2016-06-21 | |
| 264 | 1 | b Wiley,c 2016 |
| 520 | a The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer. Through genomewide association study of up to 30884 adults of European ancestry from 21 studies, we confirmed and extended the list of previously identified loci associated with circulating IGF-I and IGFBP-3 concentrations (IGF1, IGFBP3, GCKR, TNS3, GHSR, FOXO3, ASXL2, NUBP2/IGFALS, SORCS2, and CELSR2). Significant sex interactions, which were characterized by different genotype–phenotype associations between men and women, were found only for associations of IGFBP-3 concentrations with SNPs at the loci IGFBP3 and SORCS2. Analyses of SNPs, gene expression, and protein levels suggested that interplay between IGFBP3 and genes within the NUBP2 locus (IGFALS and HAGH) may affect circulating IGF-I and IGFBP-3 concentrations. The IGF-I-decreasing allele of SNP rs934073, which is an eQTL of ASXL2, was associated with lower adiposity and higher likelihood of survival beyond 90years. The known longevity-associated variant rs2153960 (FOXO3) was observed to be a genomewide significant SNP for IGF-I concentrations. Bioinformatics analysis suggested enrichment of putative regulatory elements among these IGF-I- and IGFBP-3-associated loci, particularly of rs646776 at CELSR2. In conclusion, this study identified several loci associated with circulating IGF-I and IGFBP-3 concentrations and provides clues to the potential role of the IGF axis in mediating effects of known (FOXO3) and novel (ASXL2) longevity-associated loci. © 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
| 653 | a aging | |
| 653 | a genomewide association study | |
| 653 | a growth hormone axis | |
| 653 | a IGF-I | |
| 653 | a IGFBP-3 | |
| 653 | a longevity | |
| 700 | 1 | a Qi, Q.u Yeshiva University,Harvard University4 aut |
| 700 | 1 | a Nethander, Maria,d 1980u University of Gothenburg,Gothenburg University,Göteborgs universitet,Core Facilities, Bioinformatics,Centre for Bone and Arthritis Research,Core Facilities, Bioinformatics4 aut0 (Swepub:gu)xnetma |
| 700 | 1 | a Aschard, H.u Harvard University,New York University,EURAC Research4 aut |
| 700 | 1 | a Bandinelli, S.4 aut |
| 700 | 1 | a Beekman, M.u Leiden University Medical Centre4 aut |
| 700 | 1 | a Berndt, S. I.u National Cancer Institute, USA,Boston University4 aut |
| 700 | 1 | a Bidlingmaier, M.u Ludwig-Maximilian University of Munich4 aut |
| 700 | 1 | a Broer, L.u Erasmus University Medical Center4 aut |
| 700 | 1 | a Cappola, A.u University of Pennsylvania4 aut |
| 700 | 1 | a Ceda, G. P.u University of Parma4 aut |
| 700 | 1 | a Chanock, S.u University of Greifswald4 aut |
| 700 | 1 | a Chen, M. H.u Boston University,Parma University Hospital,University of Parma4 aut |
| 700 | 1 | a Chen, T. C.u Boston University,National Institute on Aging, United States4 aut |
| 700 | 1 | a Chen, Y. D. I.u University of California, Los Angeles4 aut |
| 700 | 1 | a Chung, J.u Yeshiva University4 aut |
| 700 | 1 | a Del Greco Miglianico, F.u EURAC Research,University of Lübeck4 aut |
| 700 | 1 | a Eriksson, Joelu University of Gothenburg,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xerjoe |
| 700 | 1 | a Ferrucci, L.u National Institute on Aging, United States,Icahn School of Medicine at Mount Sinai4 aut |
| 700 | 1 | a Friedrich, N.u University of Greifswald4 aut |
| 700 | 1 | a Gnewuch, C.u University of Regensburg4 aut |
| 700 | 1 | a Goodarzi, M. O.u Cedars-Sinai Medical Center4 aut |
| 700 | 1 | a Grarup, N.u University of Copenhagen4 aut |
| 700 | 1 | a Guo, T.u Yeshiva University4 aut |
| 700 | 1 | a Hammer, E.u University of Greifswald4 aut |
| 700 | 1 | a Hayes, R. B.4 aut |
| 700 | 1 | a Hicks, A. A.4 aut |
| 700 | 1 | a Hofman, A.u Erasmus University Medical Center4 aut |
| 700 | 1 | a Houwing-Duistermaat, J. J.u Leiden University Medical Centre4 aut |
| 700 | 1 | a Hu, F.u Harvard University4 aut |
| 700 | 1 | a Hunter, D. J.u Harvard University4 aut |
| 700 | 1 | a Husemoen, L. L.u Research Centre for Prevention and Health4 aut |
| 700 | 1 | a Isaacs, A.u Erasmus University Medical Center,Leiden University Medical Centre4 aut |
| 700 | 1 | a Jacobs, K. B.u University of Greifswald4 aut |
| 700 | 1 | a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,University of Gothenburg,Massachusetts General Hospital,Harvard University,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xlomat |
| 700 | 1 | a Jansson, John-Olov,d 1954u University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xjanjo |
| 700 | 1 | a Jehmlich, N.u Helmholtz Centre for Environmental Research (UFZ),University of Greifswald4 aut |
| 700 | 1 | a Johnson, S.u Yeshiva University4 aut |
| 700 | 1 | a Juul, A.4 aut |
| 700 | 1 | a Karlsson, Magnusu Lund University,Lunds universitet,Ortopedi,Forskargrupper vid Lunds universitet,Orthopedics,Lund University Research Groups4 aut0 (Swepub:lu)orto-mka |
| 700 | 1 | a Kilpelainen, T. O.u University of Copenhagen4 aut |
| 700 | 1 | a Kovacs, P.u Leipzig University4 aut |
| 700 | 1 | a Kraft, P.u Harvard University4 aut |
| 700 | 1 | a Li, C.u Yeshiva University4 aut |
| 700 | 1 | a Linneberg, A.4 aut |
| 700 | 1 | a Liu, Y.u Wake Forest University4 aut |
| 700 | 1 | a Loos, R. J. F.4 aut |
| 700 | 1 | a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xlomat |
| 700 | 1 | a Lu, Y.u Icahn School of Medicine at Mount Sinai4 aut |
| 700 | 1 | a Maggio, M.u University of Washington, Seattle,Erasmus University Medical Center,Leiden University Medical Centre4 aut |
| 700 | 1 | a Magi, R.u University of Tartu,University of Oxford4 aut |
| 700 | 1 | a Meigs, J.4 aut |
| 700 | 1 | a Mellström, Dan,d 1945u University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xmelda |
| 700 | 1 | a Nauck, M.u Harvard University,McGill University4 aut |
| 700 | 1 | a Newman, A. B.u University of Pittsburgh4 aut |
| 700 | 1 | a Pollak, M. N.4 aut |
| 700 | 1 | a Pramstaller, P. P.u University of Lübeck,EURAC Research,Leiden University Medical Centre4 aut |
| 700 | 1 | a Prokopenko, I.u Imperial College London4 aut |
| 700 | 1 | a Psaty, B. M.4 aut |
| 700 | 1 | a Reincke, M.u Ludwig-Maximilian University of Munich4 aut |
| 700 | 1 | a Rimm, E. B.u Harvard University4 aut |
| 700 | 1 | a Rotter, J. I.u University of California, Los Angeles4 aut |
| 700 | 1 | a Saint Pierre, A.4 aut |
| 700 | 1 | a Schurmann, C.u Icahn School of Medicine at Mount Sinai4 aut |
| 700 | 1 | a Seshadri, S.u Boston University4 aut |
| 700 | 1 | a Sjögren, Klara,d 1970u University of Gothenburg,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xsjokl |
| 700 | 1 | a Slagboom, P. E.4 aut |
| 700 | 1 | a Strickler, H. D.u Yeshiva University4 aut |
| 700 | 1 | a Stumvoll, M.u Leipzig University4 aut |
| 700 | 1 | a Suh, Y.u Yeshiva University,Guangdong Medical College4 aut |
| 700 | 1 | a Sun, Q.4 aut |
| 700 | 1 | a Zhang, C.u National Institutes of Health, United States4 aut |
| 700 | 1 | a Svensson, Johan,d 1964u University of Gothenburg,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xsjohc |
| 700 | 1 | a Tanaka, T.4 aut |
| 700 | 1 | a Tare, A.u Yeshiva University4 aut |
| 700 | 1 | a Tönjes, A.u Leipzig University4 aut |
| 700 | 1 | a Uh, H. W.u Leiden University Medical Centre,University of Greifswald4 aut |
| 700 | 1 | a Van Duijn, C. M.4 aut |
| 700 | 1 | a van Heemst, D.u Leiden University Medical Centre4 aut |
| 700 | 1 | a Vandenput, Liesbeth,d 1974u University of Gothenburg,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xvanli |
| 700 | 1 | a Vasan, R. S.4 aut |
| 700 | 1 | a Völker, U.u University of Greifswald4 aut |
| 700 | 1 | a Willems, Sara M.4 aut |
| 700 | 1 | a Ohlsson, Claes,d 1965u University of Gothenburg,Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xohlcl |
| 700 | 1 | a Wallaschofski, H.4 aut |
| 700 | 1 | a Kaplan, R. C.u Yeshiva University4 aut |
| 710 | 2 | a University of Greifswaldb Yeshiva University4 org |
| 773 | 0 | t Aging Celld : Wileyg 15:5, s. 811-824q 15:5<811-824x 1474-9718x 1474-9726 |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.12490 |
| 856 | 4 | u http://dx.doi.org/10.1111/acel.12490x freey FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/244481 |
| 856 | 4 8 | u https://doi.org/10.1111/acel.12490 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/a6671480-24db-4d09-a28f-7c879806584f |
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