Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone

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Fältnamn	Indikatorer	Metadata
000		03801naa a2200457 4500
001		oai:lup.lub.lu.se:e0706f09-ec19-4576-abf3-729d55e3ca06
003		SwePub
008		160401s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/14618892 URI
024	7	a https://doi.org/10.1111/j.1755-3768.2008.01300.x2 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Fosmark, Dag S.4 aut
245	1 0	a Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone
264	1	b Wiley,c 2009
520		a Purpose: We aimed to investigate associations between serum levels of the advanced glycation endproduct methylglyoxal-derived hydroimidazolone (MG-H1) and retinopathy in a sample of patients with type 1 diabetes. Methods: We conducted a cross-sectional study in a Scandinavian ophthalmology outpatient clinic on 61 randomly selected patients with type 1 diabetes. Blood samples and retinal photographs were taken at the same visit. Serum levels of hydroimidazolone immunoreactivity were determined using an immunoassay, and levels of retinopathy were determined from seven standard field stereo photographs of each eye according to the ETDRS method. Results were compared between patients with and without retinopathy. Results: Hydroimidazolone quartiles were significantly associated with retinopathy (p = 0.013). The most profound increase in occurrence of retinopathy was observed from the lowest to the second-lowest hydroimidazolone quartile. Adjusted for duration of diabetes using logistic regression, a significant difference in the presence of retinopathy was found when comparing the lowest quartile with the rest (p = 0.022). Conclusions: In our patients with type 1 diabetes, serum levels of hydroimidazolone were found to be associated with retinopathy. This is in keeping with findings in a larger sample of patients with type 2 diabetes.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Oftalmologi0 (SwePub)302172 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Ophthalmology0 (SwePub)302172 hsv//eng
653		a MG-H1
653		a (MG)
653		a methylglyoxal
653		a advanced glycation endproducts (AGEs)
653		a hydroimidazolone
653		a retinopathy
653		a type 1 diabetes
700	1	a Berg, Jens P.4 aut
700	1	a Jensen, Aase-Brith4 aut
700	1	a Sandvik, Leiv4 aut
700	1	a Agardh, Elisabetu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Oftalmologi (Malmö),Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Ophthalmology (Malmö),Lund University Research Groups4 aut0 (Swepub:lu)ofta-eag
700	1	a Agardh, Carl-Davidu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)endo-cag
700	1	a Hanssen, Kristian F.4 aut
710	2	a Institutionen för kliniska vetenskaper, Malmöb Medicinska fakulteten4 org
773	0	t Acta Ophthalmologicad : Wileyg 87:5, s. 498-500q 87:5<498-500x 1755-3768x 1755-375X
856	4	u http://dx.doi.org/10.1111/j.1755-3768.2008.01300.xy FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/1461889
856	4 8	u https://doi.org/10.1111/j.1755-3768.2008.01300.x

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

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