Sökning: WFRF:(Lagerstrand Kerstin M) > (2020-2024) > A Reperfusion BOLD-...
Fältnamn | Indikatorer | Metadata |
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000 | 04907naa a2200493 4500 | |
001 | oai:gup.ub.gu.se/308092 | |
003 | SwePub | |
008 | 240528s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3080922 URI |
024 | 7 | a https://doi.org/10.3390/jcm101636432 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Törngren, Kristinau Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut |
245 | 1 0 | a A Reperfusion BOLD-MRI Tissue Perfusion Protocol Reliably Differentiate Patients with Peripheral Arterial Occlusive Disease from Healthy Controls |
264 | c 2021-08-18 | |
264 | 1 | b MDPI AG,c 2021 |
520 | a There is no established technique that directly quantifies lower limb tissue perfusion. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is an MRI technique that can determine skeletal muscle perfusion. BOLD-MRI relies on magnetic differences of oxygenated and deoxygenated hemoglobin, and regional changes in oxy/deoxyhemoglobin ratio can be recorded by T2* weighted MRI sequences. We aimed to test whether BOLD-MRI can differentiate lower limb tissue perfusion in peripheral arterial occlusive disease (PAOD) patients and healthy controls. Twenty-two PAOD patients and ten healthy elderly volunteers underwent lower limb BOLD-MRI. Reactive hyperemia was provoked by transient cuff compression and images of the gastrocnemius and soleus muscles were continuously acquired at rest, during ischemia and reperfusion. Key BOLD parameters were baseline T2* absolute value and time to T2* peak value after cuff deflation (TTP). Correlations between imaging parameters and ankle-brachial index (ABI) was investigated. The mean TTP was considerably prolonged in PAOD patients compared to healthy controls (m. gastrocnemius: 111 +/- 46 versus 48 +/- 22 s, p = 0.000253; m. soleus: 100 +/- 42 versus 41 +/- 30 s, p = 0.000216). Both gastrocnemius and soleus TTP values correlated strongly with ABI (-0.82 and -0.78, p < 0.01). BOLD-MRI during reactive hyperemia differentiated most PAOD patients from healthy controls. TTP was the most decisive parameter and strongly correlated with the ABI. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
653 | a peripheral arterial occlusive disease | |
653 | a atherosclerosis | |
653 | a intermittent | |
653 | a claudication | |
653 | a BOLD MRI | |
653 | a tissue perfusion | |
653 | a skeletal-muscle | |
653 | a oxygenation | |
653 | a calf | |
653 | a General & Internal Medicine | |
700 | 1 | a Eriksson, Stefanieu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för medicinsk strålningsvetenskap,Institute of Clinical Sciences, Department of Medical Radiation Sciences4 aut0 (Swepub:gu)xestef |
700 | 1 | a Arvidsson, Jonathanu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för medicinsk strålningsvetenskap,Institute of Clinical Sciences, Department of Medical Radiation Sciences4 aut0 (Swepub:gu)xarvjo |
700 | 1 | a Falkenberg, Mårten,d 1959u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology4 aut0 (Swepub:gu)xfalke |
700 | 1 | a Johnsson, Åse (Allansdotter),d 1966u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology4 aut0 (Swepub:gu)xjohna |
700 | 1 | a Sjoberg, C.4 aut |
700 | 1 | a Lagerstrand, Kerstin Mu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för medicinsk strålningsvetenskap,Institute of Clinical Sciences, Department of Medical Radiation Sciences4 aut0 (Swepub:gu)xlagke |
700 | 1 | a Nordanstig, Joakimu Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xnjoak |
710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org |
773 | 0 | t Journal of Clinical Medicined : MDPI AGg 10:16q 10:16x 2077-0383 |
856 | 4 | u https://www.mdpi.com/2077-0383/10/16/3643/pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/308092 |
856 | 4 8 | u https://doi.org/10.3390/jcm10163643 |
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