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Antioxidant enzymes...
Antioxidant enzymes and Nrf2/Keap1 in human skeletal muscle: Influence of age, sex, adiposity and aerobic fitness
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- Galvan-Alvarez, Victor (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain
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- Gallego-Selles, Angel (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain
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- Martinez-Canton, Miriam (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain
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- García-Gonzalez, Eduardo (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain
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- Gelabert-Rebato, Miriam (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain
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- Ponce-Gonzalez, Jesus Gustavo (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain
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- Larsen, Steen (författare)
- Center of Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark; Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland
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- Morales-Alamo, David (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain
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- Losa-Reyna, Jose (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain
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- Perez-Suarez, Ismael (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain
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- Dorado, Cecilia (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain
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- Perez-Valera, Mario (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain
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- Holmberg, Hans-Christer (författare)
- Luleå tekniska universitet,Hälsa, medicin och rehabilitering,School of Kinesiology, Faculty of Education, The University of British Columbia, Vancouver, BC, Canada
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- Boushel, Robert (författare)
- School of Kinesiology, Faculty of Education, The University of British Columbia, Vancouver, BC, Canada
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- de Pablos Velasco, Pedro (författare)
- Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain; Department of Endocrinology and Nutrition, Hospital Universitario de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria, Spain
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- Helge, Jorn Wulff (författare)
- Center of Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark
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- Martin-Rincon, Marcos (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain
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- Calbet, Jose A.L. (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe “Fisico” s/n, 35017, Las Palmas de Gran Canaria, Spain; School of Kinesiology, Faculty of Education, The University of British Columbia, Vancouver, BC, Canada; Department of Physical Performance, The Norwegian School of Sport Sciences, Postboks, 4014 Ulleval Stadion, 0806, Oslo, Norway
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(creator_code:org_t)
- Elsevier Inc. 2023
- 2023
- Engelska.
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Ingår i: Free Radical Biology & Medicine. - : Elsevier Inc.. - 0891-5849 .- 1873-4596. ; 209:Part 2, s. 282-291
- Relaterad länk:
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https://doi.org/10.1...
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https://ltu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Whether a higher aerobic fitness is associated with increased expression of antioxidant enzymes and their regulatory factors in skeletal muscle remains unknown. Although oestrogens could promote a higher antioxidant capacity in females, it remains unknown whether a sex dimorphism exists in humans regarding the antioxidant capacity of skeletal muscle. Thus, the aim was to determine the protein expression levels of the antioxidant enzymes SOD1, SOD2, catalase and glutathione reductase (GR) and their regulatory factors Nrf2 and Keap1 in 189 volunteers (120 males and 69 females) to establish whether sex differences exist and how age, VO2max and adiposity influence these. For this purpose, vastus lateralis muscle biopsies were obtained in all participants under resting and unstressed conditions. No significant sex differences in Nrf2, Keap1, SOD1, SOD2, catalase and GR protein expression levels were observed after accounting for VO2max, age and adiposity differences. Multiple regression analysis indicates that the VO2max in mL.kg LLM−1.min−1can be predicted from the levels of SOD2, Total Nrf2 and Keap1 (R = 0.58, P < 0.001), with SOD2 being the main predictor explaining 28 % of variance in VO2max, while Nrf2 and Keap1 explained each around 3 % of the variance. SOD1 protein expression increased with ageing in the whole group after accounting for differences in VO2max and body fat percentage. Overweight and obesity were associated with increased pSer40-Nrf2, pSer40-Nrf2/Total Nrf2 ratio and SOD1 protein expression levels after accounting for differences in age and VO2max. Overall, at the population level, higher aerobic fitness is associated with increased basal expression of muscle antioxidant enzymes, which may explain some of the benefits of regular exercise.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Aging
- Catalase
- Free radicals
- Nrf2
- Obesity
- Physical activity
- ROS
- SOD
- Physiotherapy
- Fysioterapi
- Centre - Centre for Sports and Performance Technology (SPORTC)
- Centrumbildning - Centrum för idrotts- och prestationsteknologi (SPORTC)
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Galvan-Alvarez, ...
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Gallego-Selles, ...
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Martinez-Canton, ...
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García-Gonzalez, ...
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Gelabert-Rebato, ...
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Ponce-Gonzalez, ...
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Larsen, Steen
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Morales-Alamo, D ...
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Losa-Reyna, Jose
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Perez-Suarez, Is ...
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Dorado, Cecilia
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Perez-Valera, Ma ...
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Holmberg, Hans-C ...
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Boushel, Robert
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de Pablos Velasc ...
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Helge, Jorn Wulf ...
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Martin-Rincon, M ...
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Calbet, Jose A.L ...
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Fysiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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