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Relationship between iron deficiency and expression of genes involved in iron metabolism in human myocardium and skeletal muscle
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- Cabrera, C. (författare)
- Karolinska Institutet,Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci & Educ, Dept Cardiol, Sodersjukhuset, Sjukhusbacken 10, SE-11883 Stockholm, Sweden.
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- Frisk, Christoffer (författare)
- Uppsala universitet,Beräkningsbiologi och bioinformatik,Science for Life Laboratory, SciLifeLab
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- Lofstrom, U. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med, Stockholm, Sweden.
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- Lynga, P. (författare)
- Karolinska Institutet,Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.
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- Linde, C. (författare)
- Karolinska Inst, Dept Med, Stockholm, Sweden.
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- Hage, C. (författare)
- Karolinska Inst, Dept Med, Stockholm, Sweden.
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- Persson, H. (författare)
- Karolinska Institutet,Danderyd Hosp, Karolinska Inst, Div Cardiovasc Med, Dep Clin Sci, Stockholm, Sweden.
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- Eriksson, M. J. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, Solna, Sweden.
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- Wallen, H. (författare)
- Karolinska Institutet,Danderyd Hosp, Karolinska Inst, Div Cardiovasc Med, Dep Clin Sci, Stockholm, Sweden.
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- Persson, Bengt (författare)
- Uppsala universitet,Beräknings- och systembiologi,Science for Life Laboratory, SciLifeLab,Beräkningsbiologi och bioinformatik
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- Ekstrom, M. (författare)
- Karolinska Institutet,Danderyd Hosp, Karolinska Inst, Div Cardiovasc Med, Dep Clin Sci, Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden;Karolinska Inst, Dept Clin Sci & Educ, Dept Cardiol, Sodersjukhuset, Sjukhusbacken 10, SE-11883 Stockholm, Sweden. (creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: International Journal of Cardiology. - : Elsevier. - 0167-5273 .- 1874-1754. ; 379, s. 82-88
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Iron deficiency (ID) is associated with adverse prognosis in patients with heart failure. This study aims to investigate the relationship between ID and expression of genes involved in iron metabolism in human myocardium and skeletal muscle, focusing on Transferrin 1 receptor (TfR1), the main pathway of cellular iron uptake.Methods: Patients undergoing elective CABG were assessed prior to surgery with echocardiography and serum iron parameters. Core needle biopsies were collected from the left and right ventricle (LV, RV), the right atrium and intercostal skeletal muscle (SM). Gene expression analyses were done by mRNA sequencing.Results: Of 69 patients (median age 69 years, 91% men), 28% had ID. 26% had HFrEF, 25% had HFpEF phys-iology according to echocardiographic findings and NT-proBNP levels, and 49% had normal LV function. The expression of TfR1 was increased in patients with ID compared to patients without ID in ventricular tissue (p = 0.04) and in intercostal SM (p = 0.01). The increase in TfR1 expression in LV and RV was more pronounced when analysing patients with absolute ID (S-Ferritin<100 mu g/L). Analysing the correlation between various iron pa-rameters, S-Ferritin levels showed the strongest correlation with TfR1 expression. There was no correlation with NT-proBNP levels and no difference in TfR1 expression between different HF phenotypes.Conclusions: In patients undergoing elective CABG we found an association between ID and increased TfR1 expression in myocardium regardless of LV function, indicating physiologically upregulated TfR1 expression in the presence of ID to restore intracellular iron needs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Iron deficiency
- Heart failure
- Iron metabolism
- Myocardial metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Cabrera, C.
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Frisk, Christoff ...
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Lofstrom, U.
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Lynga, P.
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Linde, C.
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Hage, C.
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Persson, H.
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Eriksson, M. J.
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Wallen, H.
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Persson, Bengt
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Ekstrom, M.
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