Disease activity and damage accrual during the early disease course in a multinational inception cohort of patients with systemic lupus erythematosus

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Fältnamn	Indikatorer	Metadata
000		03188naa a2200421 4500
001		oai:prod.swepub.kib.ki.se:120900236
003		SwePub
008		240811s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1209002362 URI
024	7	a https://doi.org/10.1177/09612033103665722 DOI
040		a (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Nossent, J4 aut
245	1 0	a Disease activity and damage accrual during the early disease course in a multinational inception cohort of patients with systemic lupus erythematosus
264		c 2010-04-07
264	1	b SAGE Publications,c 2010
520		a An inception cohort of patients with systemic lupus erythematosus from 14 European centres was followed for up to 5 years in order to describe the current early disease course. At inclusion patients (n = 200, 89% female, mean age 35 years, 97% Caucasian, mean SLEDAI 12.2) fulfilled a mean of 6.5 ACR classification criteria. The most prevalent criteria were antinuclear Ab presence (97%) followed by anti-dsDNA Ab (74%), arthritis (69%), leukocytopenia (54%) and malar rash (53%), antiphospholipid Ab (48%) and anti-synovial membrane Ab (21.6%). Clinical signs of lupus nephritis (LN) were present in 39% with biopsy-confirmed LN seen in 25%. Frequent additional findings were hypocomplementaemia (54%), anti-SSA Ab (49%), alopecia (26%) and Raynaud’s phenomenon (31%). There were few regional differences in disease presentation and management. One and 5-year survival rates were 99% and 97% respectively. During the mean follow-up of 4.1 years 25% entered a state of early disease quiescence by global physician assessment, but the overall risk of subsequent flare was 60%. Maximum SLEDAI scores decreased over time, but 45% of patients accrued damage (SDI ≥1) for which baseline presence of proteinuria and persistent disease activity were independent predictors. The results indicate minor differences in SLE presentation and treatment within various regions of Europe and a high diagnostic reliance on anti-dsDNA Ab. Despite early reductions in disease activity and improved mortality, the risk for disease flare and damage development is, however, still substantial, especially in patients not entering an early remission.
700	1	a Kiss, E4 aut
700	1	a Rozman, B4 aut
700	1	a Pokorny, G4 aut
700	1	a Vlachoyiannopoulos, P4 aut
700	1	a Olesinska, M4 aut
700	1	a Marchesoni, A4 aut
700	1	a Mosca, M4 aut
700	1	a Pai, S4 aut
700	1	a Manger, K4 aut
700	1	a Schneider, M4 aut
700	1	a Nielsen, H4 aut
700	1	a van Vollenhoven, Ru Karolinska Institutet4 aut
700	1	a Swaak, T4 aut
710	2	a Karolinska Institutet4 org
773	0	t Lupusd : SAGE Publicationsg 19:8, s. 949-956q 19:8<949-956x 1477-0962x 0961-2033
856	4	u https://opus4.kobv.de/opus4-fau/files/2975/nossent_disease_4226.pdf
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:120900236
856	4 8	u https://doi.org/10.1177/0961203310366572

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Av författaren/redakt...: Nossent, J; Kiss, E; Rozman, B; Pokorny, G; Vlachoyiannopoul ...; Olesinska, M; visa fler...; Marchesoni, A; Mosca, M; Pai, S; Manger, K; Schneider, M; Nielsen, H; van Vollenhoven, ...; Swaak, T; visa färre...

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