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Value of Intact Pro...
Value of Intact Prostate Specific Antigen and Human Kallikrein 2 in the 4 Kallikrein Predictive Model : An Individual Patient Data Meta-Analysis
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- Vickers, Andrew (författare)
- Memorial Sloan-Kettering Cancer Center
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- Vertosick, Emily A. (författare)
- Memorial Sloan-Kettering Cancer Center
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- Sjoberg, Daniel D. (författare)
- Memorial Sloan-Kettering Cancer Center
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- Hamdy, Freddie (författare)
- University of Oxford
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- Neal, David (författare)
- University of Oxford
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- Bjartell, Anders (författare)
- Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups
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- Hugosson, Jonas (författare)
- University of Gothenburg
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- Donovan, Jenny L. (författare)
- University of Bristol
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- Villers, Arnauld (författare)
- Lille 2 University
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- Zappala, Stephen (författare)
- Andover Urology
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- Lilja, Hans (författare)
- Memorial Sloan-Kettering Cancer Center
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2018
- 2018
- Engelska.
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Ingår i: Journal of Urology. - : Ovid Technologies (Wolters Kluwer Health). - 0022-5347 .- 1527-3792. ; 199:6, s. 1470-1474
- Relaterad länk:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Purpose: The 4 kallikrein panel, commercially available as the 4Kscore®, is a statistical model that has been shown to accurately predict Gleason Grade Group 2 or greater (high grade) cancer on biopsy and the long-term risk of distant prostate cancer metastases. The panel includes 2 novel markers, namely intact prostate specific antigen and hK2. It has been questioned whether these 2 additional markers add discrimination to the clinical predictors of patient age, digital rectal examination and prior biopsy, and the established molecular markers total and free prostate specific antigen. Materials and Methods: We performed an individual patient data meta-analysis of published studies in which the 4 kallikrein panel was measured in men undergoing prostate biopsy. We assess the improvement in discrimination associated with including intact prostate specific antigen and hK2 along with total and free prostate specific antigen in the statistical model. Results: Included in analysis were 14,510 men from a total of 10 studies. The fixed effects meta-analytical estimate of the discrimination of the model without intact prostate specific antigen and hK2 was 0.742 (95% CI 0.727–0.756) compared to 0.813 (95% CI 0.801–0.825) for the full kallikrein model. The 95% CIs did not overlap and the difference in discrimination was highly statistically significant (0.069, 95% CI 0.057–0.080, p <0.0001). Intact prostate specific antigen (increase in discrimination 0.059, 95% CI 0.050–0.069) and hK2 (increase in discrimination 0.024, 95% CI 0.020–0.029, each p <0.0001) added independently to the model. Conclusions: The clinical value of the panel could not be replicated using data readily available to urologists without measuring intact prostate specific antigen and hK2.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- digital rectal examination
- early detection of cancer
- kallikreins
- prostate-specific antigen
- prostatic neoplasms
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- Av författaren/redakt...
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Vickers, Andrew
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Vertosick, Emily ...
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Sjoberg, Daniel ...
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Hamdy, Freddie
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Neal, David
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Bjartell, Anders
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visa fler...
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Hugosson, Jonas
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Donovan, Jenny L ...
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Villers, Arnauld
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Zappala, Stephen
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Lilja, Hans
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Lunds universitet