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Search: WFRF:(Sjoberg Daniel) > Value of Intact Pro...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004544naa a2200493 4500
001oai:lup.lub.lu.se:7ddd135a-a5c5-4567-b928-0f893035e0ae
003SwePub
008180507s2018 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/7ddd135a-a5c5-4567-b928-0f893035e0ae2 URI
0247 a https://doi.org/10.1016/j.juro.2018.01.0702 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Vickers, Andrewu Memorial Sloan-Kettering Cancer Center4 aut
2451 0a Value of Intact Prostate Specific Antigen and Human Kallikrein 2 in the 4 Kallikrein Predictive Model : An Individual Patient Data Meta-Analysis
264 1b Ovid Technologies (Wolters Kluwer Health),c 2018
520 a Purpose: The 4 kallikrein panel, commercially available as the 4Kscore®, is a statistical model that has been shown to accurately predict Gleason Grade Group 2 or greater (high grade) cancer on biopsy and the long-term risk of distant prostate cancer metastases. The panel includes 2 novel markers, namely intact prostate specific antigen and hK2. It has been questioned whether these 2 additional markers add discrimination to the clinical predictors of patient age, digital rectal examination and prior biopsy, and the established molecular markers total and free prostate specific antigen. Materials and Methods: We performed an individual patient data meta-analysis of published studies in which the 4 kallikrein panel was measured in men undergoing prostate biopsy. We assess the improvement in discrimination associated with including intact prostate specific antigen and hK2 along with total and free prostate specific antigen in the statistical model. Results: Included in analysis were 14,510 men from a total of 10 studies. The fixed effects meta-analytical estimate of the discrimination of the model without intact prostate specific antigen and hK2 was 0.742 (95% CI 0.727–0.756) compared to 0.813 (95% CI 0.801–0.825) for the full kallikrein model. The 95% CIs did not overlap and the difference in discrimination was highly statistically significant (0.069, 95% CI 0.057–0.080, p <0.0001). Intact prostate specific antigen (increase in discrimination 0.059, 95% CI 0.050–0.069) and hK2 (increase in discrimination 0.024, 95% CI 0.020–0.029, each p <0.0001) added independently to the model. Conclusions: The clinical value of the panel could not be replicated using data readily available to urologists without measuring intact prostate specific antigen and hK2.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a digital rectal examination
653 a early detection of cancer
653 a kallikreins
653 a prostate-specific antigen
653 a prostatic neoplasms
7001 a Vertosick, Emily A.u Memorial Sloan-Kettering Cancer Center4 aut
7001 a Sjoberg, Daniel D.u Memorial Sloan-Kettering Cancer Center4 aut
7001 a Hamdy, Freddieu University of Oxford4 aut
7001 a Neal, Davidu University of Oxford4 aut
7001 a Bjartell, Andersu Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)kir-abj
7001 a Hugosson, Jonasu University of Gothenburg4 aut
7001 a Donovan, Jenny L.u University of Bristol4 aut
7001 a Villers, Arnauldu Lille 2 University4 aut
7001 a Zappala, Stephenu Andover Urology4 aut
7001 a Lilja, Hansu Memorial Sloan-Kettering Cancer Center4 aut0 (Swepub:lu)klke-hli
7102 a Memorial Sloan-Kettering Cancer Centerb University of Oxford4 org
7730 t Journal of Urologyd : Ovid Technologies (Wolters Kluwer Health)g 199:6, s. 1470-1474q 199:6<1470-1474x 0022-5347x 1527-3792
8564 u http://dx.doi.org/10.1016/j.juro.2018.01.070y FULLTEXT
8564 u https://europepmc.org/articles/pmc6596413?pdf=render
8564 8u https://lup.lub.lu.se/record/7ddd135a-a5c5-4567-b928-0f893035e0ae
8564 8u https://doi.org/10.1016/j.juro.2018.01.070

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