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Respiratory superco...
Respiratory supercomplexes enhance electron transport by decreasing cytochrome c diffusion distance
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- Berndtsson, Jens (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Aufschnaiter, Andreas (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Rathore, Sorbhi (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Marin-Buera, L. (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Dawitz, Hannah (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Diessl, Jutta (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Kohler, Verena, 1992- (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Barrientos, A. (author)
- Department of Neurology Miller School of Medicine University of Miami Miami FL USA;Department of Biochemistry and Molecular Biology Miller School of Medicine University of Miami Miami FL USA
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- Büttner, Sabrina (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,University of Graz, Austria
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- Fontanesi, F. (author)
- Department of Biochemistry and Molecular Biology Miller School of Medicine University of Miami Miami FL USA
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- Ott, Martin, 1974 (author)
- Stockholms universitet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Department of Biochemistry and Biophysics Stockholm University Stockholm Sweden;Department of Medical Biochemistry and Cell Biology University of Gothenburg Gothenburg Sweden,Institutionen för biokemi och biofysik
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- Kohler, Andreas, Dr. rer. nat. 1988- (author)
- Department of Biochemistry and Biophysics Stockholm University Stockholm Sweden
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(creator_code:org_t)
- 2020-10-05
- 2020
- English.
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In: Embo Reports. - : EMBO. - 1469-221X .- 1469-3178. ; 21
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Abstract
Subject headings
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- Respiratory chains are crucial for cellular energy conversion and consist of multi-subunit complexes that can assemble into supercomplexes. These structures have been intensively characterized in various organisms, but their physiological roles remain unclear. Here, we elucidate their function by leveraging a high-resolution structural model of yeast respiratory supercomplexes that allowed us to inhibit supercomplex formation by mutation of key residues in the interaction interface. Analyses of a mutant defective in supercomplex formation, which still contains fully functional individual complexes, show that the lack of supercomplex assembly delays the diffusion of cytochromec between the separated complexes, thus reducing electron transfer efficiency. Consequently, competitive cellular fitness is severely reduced in the absence of supercomplex formation and can be restored by overexpression of cytochromec. In sum, our results establish how respiratory supercomplexes increase the efficiency of cellular energy conversion, thereby providing an evolutionary advantage for aerobic organisms.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- bioenergetics
- competitive fitness
- cryo-EM
- mitochondria
- respiratory
- chain supercomplexes
- complex-i
- kinetic evidence
- bc(1) complex
- b synthesis
- chain
- yeast
- assembly/stability
- visualization
- mitochondria
- relevance
- Biochemistry & Molecular Biology
- Cell Biology
- bioenergetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Berndtsson, Jens
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Aufschnaiter, An ...
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Rathore, Sorbhi
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Marin-Buera, L.
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Dawitz, Hannah
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Diessl, Jutta
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show more...
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Kohler, Verena, ...
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Barrientos, A.
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Büttner, Sabrina
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Fontanesi, F.
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Ott, Martin, 197 ...
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Kohler, Andreas, ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Embo Reports
- By the university
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University of Gothenburg
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Umeå University
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Stockholm University