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Sökning: AMNE:(TEKNIK OCH TEKNOLOGIER Industriell bioteknik Bioteknisk apparatteknik) > Synergistic augment...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04245naa a2200493 4500 | |
| 001 | oai:lup.lub.lu.se:6a73fb51-ff8b-4385-8d92-1520679dab78 | |
| 003 | SwePub | |
| 008 | 160401s2012 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:uu-179895 | |
| 024 | 7 | a https://lup.lub.lu.se/record/28595342 URI |
| 024 | 7 | a https://doi.org/10.1016/j.biomaterials.2012.05.0112 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1798952 URI |
| 040 | a (SwePub)lud (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Broos, Sisselau Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)immu-sbs |
| 245 | 1 0 | a Synergistic augmentation of CD40-mediated activation of antigen-presenting cells by amphiphilic poly(γ-glutamic acid) nanoparticles. |
| 264 | 1 | b Elsevier BV,c 2012 |
| 520 | a Agonistic anti-CD40 monoclonal antibodies (mAbs) hold great potential for cancer immunotherapy. However, systemic administration of anti-CD40 mAbs can be associated with severe side effects, such as cytokine release syndrome and liver damage. With the aim to increase the immunostimulatory potency as well as to achieve a local drug retention of anti-CD40 mAbs, we linked an agonistic mAb to immune activating amphiphilic poly(γ-glutamic acid) nanoparticles (γ-PGA NPs). We demonstrate that adsorption of anti-CD40 mAb to γ-PGA NPs (anti-CD40-NPs) improved the stimulatory capacity of the CD40 agonist, resulting in upregulation of costimulatory CD80 and CD86 on antigen-presenting cells, as well as IL-12 secretion. Interestingly, anti-CD40-NPs induced strong synergistic proliferative effects in B cells, possibly resulting from a higher degree of CD40 multimerization, enabled by display of multiple anti-CD40 mAbs on the NPs. In addition, local treatment with anti-CD40-NPs, compared to only soluble CD40 agonist, resulted in a significant reduction in serum levels of IL-6, IL-10, IL-12 and TNF-α in a bladder cancer model. Taken together, our results suggest that anti-CD40-NPs are capable of synergistically enhancing the immunostimulatory effect induced by the CD40 agonist, as well as minimizing adverse side effects associated with systemic cytokine release. This concept of nanomedicine could play an important role in localized immunotherapy of cancer. | |
| 650 | 7 | a TEKNIK OCH TEKNOLOGIERx Industriell bioteknikx Bioteknisk apparatteknik0 (SwePub)209072 hsv//swe |
| 650 | 7 | a ENGINEERING AND TECHNOLOGYx Industrial Biotechnologyx Bioengineering Equipment0 (SwePub)209072 hsv//eng |
| 653 | a Cell | |
| 653 | a proliferation | |
| 653 | a Protein adsorption | |
| 653 | a Immunostimulation | |
| 653 | a Drug delivery | |
| 653 | a Nanoparticle | |
| 653 | a Drug delivery | |
| 700 | 1 | a Sandin, Linda C.u Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)lingu457 |
| 700 | 1 | a Apel, Jennyu Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)immu-jya |
| 700 | 1 | a Tötterman, Thomas H.u Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)thomtott |
| 700 | 1 | a Akagi, Takami4 aut |
| 700 | 1 | a Akashi, Mitsuru4 aut |
| 700 | 1 | a Borrebaeck, Carlu Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)immt-cbo |
| 700 | 1 | a Ellmark, Peter4 aut |
| 700 | 1 | a Lindstedt, Malin4 aut |
| 710 | 2 | a Institutionen för immunteknologib Institutioner vid LTH4 org |
| 773 | 0 | t Biomaterialsd : Elsevier BVg 33:26, s. 6230-6239q 33:26<6230-6239x 1878-5905x 0142-9612 |
| 856 | 4 | u http://dx.doi.org/10.1016/j.biomaterials.2012.05.011y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/2859534 |
| 856 | 4 8 | u https://doi.org/10.1016/j.biomaterials.2012.05.011 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-179895 |
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