Sökning: WFRF:(Bae Sang Cheol) > Association Between...
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000 | 06243naa a2200733 4500 | |
001 | oai:lup.lub.lu.se:5abe1ce8-efbe-4d45-bf2d-fb72f16334e4 | |
003 | SwePub | |
008 | 240115s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/5abe1ce8-efbe-4d45-bf2d-fb72f16334e42 URI |
024 | 7 | a https://doi.org/10.1002/art.426452 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Nguyen, Yannu Cochin Hospital4 aut |
245 | 1 0 | a Association Between Severe Nonadherence to Hydroxychloroquine and Systemic Lupus Erythematosus Flares, Damage, and Mortality in 660 Patients From the SLICC Inception Cohort |
264 | 1 | c 2023 |
300 | a 12 s. | |
520 | a Objective: The goals of this study were to assess the associations of severe nonadherence to hydroxychloroquine (HCQ), objectively assessed by HCQ serum levels, and risks of systemic lupus erythematosus (SLE) flares, damage, and mortality rates over five years of follow-up. Methods: The Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort is an international multicenter initiative (33 centers throughout 11 countries). The serum of patients prescribed HCQ for at least three months at enrollment were analyzed. Severe nonadherence was defined by a serum HCQ level <106 ng/mL or <53 ng/mL for HCQ doses of 400 or 200 mg/day, respectively. Associations with the risk of a flare (defined as a Systemic Lupus Erythematosus Disease Activity Index 2000 increase ≥4 points, initiation of prednisone or immunosuppressive drugs, or new renal involvement) were studied with logistic regression, and associations with damage (first SLICC/American College of Rheumatology Damage Index [SDI] increase ≥1 point) and mortality with separate Cox proportional hazard models. Results: Of the 1,849 cohort participants, 660 patients (88% women) were included. Median (interquartile range) serum HCQ was 388 ng/mL (244–566); 48 patients (7.3%) had severe HCQ nonadherence. No covariates were clearly associated with severe nonadherence, which was, however, independently associated with both flare (odds ratio 3.38; 95% confidence interval [CI] 1.80–6.42) and an increase in the SDI within each of the first three years (hazard ratio [HR] 1.92 at three years; 95% CI 1.05–3.50). Eleven patients died within five years, including 3 with severe nonadherence (crude HR 5.41; 95% CI 1.43–20.39). Conclusion: Severe nonadherence was independently associated with the risks of an SLE flare in the following year, early damage, and five-year mortality. (Figure presented.). | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
700 | 1 | a Blanchet, Benoîtu Université Paris Cité4 aut |
700 | 1 | a Urowitz, Murray B.u University of Toronto4 aut |
700 | 1 | a Hanly, John G.u Dalhousie University4 aut |
700 | 1 | a Gordon, Carolineu University of Birmingham4 aut |
700 | 1 | a Bae, Sang Cheolu Hanyang University Hospital for Rheumatic Disease4 aut |
700 | 1 | a Romero-Diaz, Juanitau Salvador Zubirán National Institute of Health Sciences and Nutrition4 aut |
700 | 1 | a Sanchez-Guerrero, Jorgeu Mount Sinai Hospital of University of Toronto4 aut |
700 | 1 | a Clarke, Ann E.u Cumming School of Medicine4 aut |
700 | 1 | a Bernatsky, Sashau McGill University Health Center4 aut |
700 | 1 | a Wallace, Daniel J.u University of California, Los Angeles4 aut |
700 | 1 | a Isenberg, David A.u University College London4 aut |
700 | 1 | a Rahman, Anisuru University College London4 aut |
700 | 1 | a Merrill, Joan T.u Oklahoma Medical Research Foundation4 aut |
700 | 1 | a Fortin, Paul R.u Centre hospitalier universitaire de Québec4 aut |
700 | 1 | a Gladman, Dafna D.u University of Toronto4 aut |
700 | 1 | a Bruce, Ian N.u Manchester Academic Health Science Centre4 aut |
700 | 1 | a Petri, Michelleu Johns Hopkins University School of Medicine4 aut |
700 | 1 | a Ginzler, Ellen M.u SUNY Downstate Health Sciences University4 aut |
700 | 1 | a Dooley, Mary Anneu University of North Carolina4 aut |
700 | 1 | a Ramsey-Goldman, Rosalindu Northwestern University Feinberg School of Medicine4 aut |
700 | 1 | a Manzi, Susanu Allegheny Health Network4 aut |
700 | 1 | a Jönsen, Andreasu Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)reum-ajo |
700 | 1 | a Alarcón, Graciela S.u University of Alabama4 aut |
700 | 1 | a Van Vollenhoven, Ronald F.u University of Amsterdam4 aut |
700 | 1 | a Aranow, Cynthiau Feinstein Institute for Medical Research4 aut |
700 | 1 | a Le Guern, Véroniqueu Cochin Hospital4 aut |
700 | 1 | a Mackay, Megganu Feinstein Institute for Medical Research4 aut |
700 | 1 | a Ruiz-Irastorza, Guillermou University of the Basque Country4 aut |
700 | 1 | a Lim, S. Samu Emory University4 aut |
700 | 1 | a Inanc, Muratu Istanbul University4 aut |
700 | 1 | a Kalunian, Kenneth C.u University of California, San Diego4 aut |
700 | 1 | a Jacobsen, Sørenu Copenhagen University Hospital4 aut |
700 | 1 | a Peschken, Christine A.u University of Manitoba4 aut |
700 | 1 | a Kamen, Diane L.u Medical University of South Carolina4 aut |
700 | 1 | a Askanase, Ancau Indian Institute of Technology4 aut |
700 | 1 | a Buyon, Jillu NYU Grossman School of Medicine4 aut |
700 | 1 | a Costedoat-Chalumeau, Nathalieu Cochin Hospital4 aut |
710 | 2 | a Cochin Hospitalb Université Paris Cité4 org |
773 | 0 | t Arthritis and Rheumatologyg 75:12, s. 2195-2206q 75:12<2195-2206x 2326-5191 |
856 | 4 | u http://dx.doi.org/10.1002/art.42645x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/5abe1ce8-efbe-4d45-bf2d-fb72f16334e4 |
856 | 4 8 | u https://doi.org/10.1002/art.42645 |
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