Islet cell and glutamic acid decarboxylase antibodies in hyperthyroid patients : At diagnosis and following treatment

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Fältnamn	Indikatorer	Metadata
000		04845naa a2200409 4500
001		oai:lup.lub.lu.se:0271a59f-e707-4fff-aeb3-69d938f93373
003		SwePub
008		190701s1996 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/0271a59f-e707-4fff-aeb3-69d938f933732 URI
024	7	a https://doi.org/10.1046/j.1365-2796.1996.417758000.x2 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Hallengren, B.u Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-bha
245	1 0	a Islet cell and glutamic acid decarboxylase antibodies in hyperthyroid patients : At diagnosis and following treatment
264	1	b Wiley,c 1996
520		a Objectives. To study the frequency of islet cell (ICA) and glutamic acid decarboxylase (GAD-Ab) antibodies in patients with hyperthyroidism of different types at diagnosis before treatment and in the euthyroid state following treatment. Setting. Department of Endocrinology, Malmo University Hospital, Malmo, Sweden. Subjects and design. Blood samples were collected at diagnosis from 129 hyperthyroid patients, and about 6 months later, from 78 of the patients (euthyroid state). Ninety-two patients had Graves' disease (69 females and 23 males, median age 49 years, range 17-85 years), and 37 patients had toxic nodular goitre/solitary toxic adenoma (34 females and three males, median age 69 years, range 24-86 years). Interventions. Most patients were treated by radioactive iodine following the first blood sample. Main outcome measures. ICA and GAD-Ab in serum. Results. At diagnosis of Graves' disease, ICA were detected in two out of 92 (2.2%) patients, two out of 85 (2.4%) without diabetes mellitus and in the euthyroid state in one patient. None of the patients with toxic nodular goitre/solitary toxic adenoma had detectable ICA. At diagnosis of Graves' disease, GAD65-Ab as well as GAD67-Ab were detected in 11 out of 85 (13%) patients without diabetes. As many as six out of 11 GAD67-Ab-positive patients were GAD65-Ab negative. In the euthyroid state, GAD65-Ab were found in six out of 51 (12%) and GAD67-Ab in eight out of 51 (16%) of the non-diabetic Graves' disease patients. The frequencies of GAD65-Ab and GAD67-Ab in toxic nodular goitre/solitary toxic adenoma, diabetes excluded, were 3 and 0%, respectively, in the hyperthyroid state. Conclusion. The frequency of ICA in patients with hyperthyroidism is not increased as compared to the background population. GAD-Ab seems to be associated with Graves' disease and not with hyperthyroidism. The presence of GAD67-Ab in GAD65-Ab negative sera from patients with Graves' disease indicates autoreactivity against a specific GAD67 epitope.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653		a Glutamic acid decarboxylase antibodies
653		a Gravest disease
653		a Hyperthyroidism
653		a Insulin-dependent diabetes mellitus
653		a Islet cell antibodies
653		a Radio-iodine
700	1	a Falorni, A.u Karolinska University Hospital4 aut
700	1	a Landin-Olsson, M.u Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diabetes lab,Forskargrupper vid Lunds universitet,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-mla
700	1	a Lernmark, Åu Karolinska University Hospital4 aut0 (Swepub:lu)endo-ale
700	1	a Papadopoulos, K. I.u Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)extLU-1035
700	1	a Sundkvist, G.u Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)endo-gsu
710	2	a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
773	0	t Journal of Internal Medicined : Wileyg 239:1, s. 63-68q 239:1<63-68x 0954-6820x 1365-2796
856	4	u http://dx.doi.org/10.1046/j.1365-2796.1996.417758000.xy FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/0271a59f-e707-4fff-aeb3-69d938f93373
856	4 8	u https://doi.org/10.1046/j.1365-2796.1996.417758000.x

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Av författaren/redakt...: Hallengren, B.; Falorni, A.; Landin-Olsson, M ...; Lernmark, Å; Papadopoulos, K. ...; Sundkvist, G.

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