Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

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Fältnamn	Indikatorer	Metadata
000		03668naa a2200817 4500
001		oai:DiVA.org:uu-72730
003		SwePub
008		050527s2005 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-727302 URI
024	7	a https://doi.org/10.1172/JCI191892 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Li, Xuri4 aut
245	1 0	a Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
264	1	c 2005
338		a print2 rdacarrier
520		a The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.
653		a Animals
653		a Cell Differentiation/drug effects
653		a Cell Movement/drug effects
653		a Cells; Cultured
653		a Coronary Vessels/cytology/drug effects
653		a Endothelial Cells/cytology/drug effects
653		a Hindlimb/blood supply/drug effects
653		a Humans
653		a Ischemia/chemically induced/drug therapy/metabolism/pathology
653		a Mice
653		a Microcirculation/drug effects
653		a Myocardium/metabolism/pathology
653		a Neovascularization; Physiologic/*drug effects
653		a Phosphotyrosine/metabolism
653		a Platelet-Derived Growth Factor/*pharmacology
653		a Receptors; Platelet-Derived Growth Factor/metabolism
653		a Research Support; Non-U.S. Gov't
653		a Signal Transduction
653		a Stem Cells/cytology/*drug effects
653		a MEDICINE
653		a MEDICIN
700	1	a Tjwa, Marc4 aut
700	1	a Moons, Lieve4 aut
700	1	a Fons, Pierre4 aut
700	1	a Noel, Agnes4 aut
700	1	a Ny, Annelii4 aut
700	1	a Zhou, Jian Min4 aut
700	1	a Lennartsson, Johanu Uppsala universitet,Ludwiginstitutet för cancerforskning4 aut0 (Swepub:uu)johalenn
700	1	a Li, Hong4 aut
700	1	a Luttun, Aernout4 aut
700	1	a Pontén, Annica4 aut
700	1	a Devy, Laetitia4 aut
700	1	a Bouché, Ann4 aut
700	1	a Oh, Hideyasu4 aut
700	1	a Manderveld, Ann4 aut
700	1	a Blacher, Silvia4 aut
700	1	a Communi, David4 aut
700	1	a Savi, Pierre4 aut
700	1	a Bono, Françoise4 aut
700	1	a Dewerchin, Mieke4 aut
700	1	a Foidart, Jean-Michel4 aut
700	1	a Autiero, Monica4 aut
700	1	a Herbert, Jean-Marc4 aut
700	1	a Collen, D4 aut
700	1	a Heldin, Carl-Henriku Uppsala universitet,Ludwiginstitutet för cancerforskning4 aut0 (Swepub:uu)carlheld
700	1	a Eriksson, Ulf4 aut
700	1	a Carmeliet, Peter4 aut
710	2	a Uppsala universitetb Ludwiginstitutet för cancerforskning4 org
773	0	t Journal of Clinical Investigationg 115:1, s. 118-127q 115:1<118-127x 0021-9738x 1558-8238
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-72730
856	4 8	u https://doi.org/10.1172/JCI19189

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