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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005830naa a2200481 4500
001oai:lup.lub.lu.se:6f02cc57-787a-46bc-a105-ff5c369bb85b
003SwePub
008230323s2023 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/6f02cc57-787a-46bc-a105-ff5c369bb85b2 URI
0247 a https://doi.org/10.1007/s13402-023-00789-72 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Huang, Shanu Shanghai Jiao Tong University4 aut
2451 0a Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner
264 c 2023-03-20
264 1b Springer Science and Business Media LLC,c 2023
520 a PURPOSE: Available evidence indicates that dipyridamole enhances the anti-thrombotic effects of aspirin for the prevention of secondary strokes. Aspirin is a well-known non-steroid anti-inflammatory drug. This anti-inflammatory property has turned aspirin into a potential drug for inflammation-related cancers such as colorectal cancer (CRC). Here, we aimed to explore whether the anti-cancer effect of aspirin against CRC could be improved by combined administration with dipyridamole.METHODS: Population-based clinical data analysis was conducted to assess a possible therapeutic effect of combined dipyridamole and aspirin treatment in inhibiting CRC compared with either monotherapy. This therapeutic effect was further verified in different CRC mouse models, i.e. an orthotopic xenograft mouse model, an AOM/DSS mouse model, an Apc min/+ mouse model and a patient derived xenograft (PDX) mouse model. The in vitro effects of the drugs on CRC cells were tested using CCK8 and flow cytometry assays. RNA-Seq, Western blotting, qRT-PCR and flow cytometry were used to identify the underlying molecular mechanisms. RESULTS: We found that dipyridamole combined with aspirin had a better inhibitory effect on CRC than either monotherapy alone. The enhanced anti-cancer effect of the combined use of dipyridamole with aspirin was found to rely on the induction of an overwhelmed endoplasmic reticulum (ER) stress and subsequent pro-apoptotic unfolded protein response (UPR), which was different from the anti-platelet effect.CONCLUSIONS: Our data indicate that the anti-cancer effect of aspirin against CRC may be enhanced by combined administration with dipyridamole. In case further clinical studies confirm our findings, these may be repurposed as adjuvant agents.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Zhang, Nai-Qiu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Region Skåne4 aut0 (Swepub:lu)na1267zh
7001 a Xu, Chun-Jieu Shanghai Jiao Tong University4 aut
7001 a Huang, Wu-Qingu Fujian Medical University4 aut
7001 a Li, Dong-Xueu Shanghai Jiao Tong University4 aut
7001 a Li, Junu Shanghai Jiao Tong University4 aut
7001 a Yao, Lin-Liu Shanghai Jiao Tong University4 aut
7001 a Sundquist, Kristinau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Region Skåne,Icahn School of Medicine at Mount Sinai4 aut0 (Swepub:lu)med-ksq
7001 a Sundquist, Janu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Icahn School of Medicine at Mount Sinai,Region Skåne4 aut0 (Swepub:lu)med-jsu
7001 a Jiang, Shu-Hengu Shanghai Jiao Tong University4 aut
7001 a Xing, Xinu Shanghai Fengxian District Central Hospital4 aut
7001 a Hu, Li-Pengu Shanghai Jiao Tong University4 aut
7001 a Zhang, Zhi-Gangu Shanghai Jiao Tong University4 aut
7001 a Ji, Jianguangu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Region Skåne4 aut0 (Swepub:lu)med-jji
7001 a Zhang, Xue-Liu Shanghai Jiao Tong University4 aut
7102 a Shanghai Jiao Tong Universityb Allmänmedicin och klinisk epidemiologi4 org
7730 t Cellular Oncologyd : Springer Science and Business Media LLCg 46:4, s. 953-967q 46:4<953-967x 2211-3428x 2211-3436
8564 u http://dx.doi.org/10.1007/s13402-023-00789-7y FULLTEXT
8564 8u https://lup.lub.lu.se/record/6f02cc57-787a-46bc-a105-ff5c369bb85b
8564 8u https://doi.org/10.1007/s13402-023-00789-7

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